The team also found that these genes had different functions in promoting metastasis: One group encouraged
growth of tumor cells in both breast and lungs, whereas the other only helped the new tumor thrive in the lungs.
A widespread cancer - causing protein called MYC promotes
the growth of tumor cells in part by ensuring that RNA transcripts are properly spliced, according to latest work from A * STAR researchers.
In a development that could lead to a new generation of drugs to precisely treat a range of diseases, scientists from the Florida campus of The Scripps Research Institute (TSRI) have for the first time designed a drug candidate that decreases
the growth of tumor cells in animal models in one of the hardest to treat cancers — triple negative breast cancer.
Other studies have found that nutrients in dark, leafy greens may inhibit
the growth of tumor cells in breast, skin, lung and stomach cancers and that green tea may thwart cancer development in colon, liver, breast and prostate cells.
Not exact matches
So even if a
tumor is surgically removed, it is difficult to extract every cancerous
cell; any left behind will result
in the
growth of a new
tumor.
Mogroside V has been found
in research to have the ability to inhibit
tumor growth in pancreatic cancer by interfering with the rapid dividing
of cancer
cells, preventing angiogenesis (blood flow to the
tumor), and even promoting cancer
cell death (10).
In 2010, researchers from the University of Michigan Comprehensive Cancer Center published a study in the journal Clinical Cancer Research showing that sulforaphane had the ability to kill breast cancer stem cells in mice and in lab cultures, and it also prevented the growth of new tumor cell
In 2010, researchers from the University
of Michigan Comprehensive Cancer Center published a study
in the journal Clinical Cancer Research showing that sulforaphane had the ability to kill breast cancer stem cells in mice and in lab cultures, and it also prevented the growth of new tumor cell
in the journal Clinical Cancer Research showing that sulforaphane had the ability to kill breast cancer stem
cells in mice and in lab cultures, and it also prevented the growth of new tumor cell
in mice and
in lab cultures, and it also prevented the growth of new tumor cell
in lab cultures, and it also prevented the
growth of new
tumor cells.
Cancer: Flaxseed may protect against breast cancer, prostate cancer, and colon cancer by inhibiting
tumor growth and blocking enzymes that are involved
in the spread
of tumor cells.
After EZH2 enzymes rise, their levels taper off, and then, the scientists found two to three-fold increases
in a protein called DNMT1, which maintains DNA methylation
in the «start» location
of a variety
of tumor suppressor genes that normally suppress
cell growth.
Scientists at the Rosalind Franklin University
of Medicine and Science
in Chicago found a «remarkable similarity» between the
cells that support the
growth and development
in placentas and
in tumors.
Also limiting the use
of therapeutic stem
cells to date, self - renewal, a quality so vital to a fast - growing fetus, can also be a source
of cancer risk when haphazard, unlimited
cell multiplication results
in the abnormal tissue
growth seen
in tumors.
«Our work strongly supports that cancer stem
cells are the main source
of growth in these
tumors and, as such, should be considered promising targets for treatment,» says Mario Suvà, MD, PhD,
of the MGH Department
of Pathology, co-senior author
of the Nature paper.
In addition to diminishing the tumor's energy supply, the diet slows the growth of glioblastoma cells by altering a cellular - signaling pathway that commonly occurs in cancers, according to the researcher
In addition to diminishing the
tumor's energy supply, the diet slows the
growth of glioblastoma
cells by altering a cellular - signaling pathway that commonly occurs
in cancers, according to the researcher
in cancers, according to the researchers.
An experimental drug
in early development for aggressive brain
tumors can cross the blood - brain
tumor barrier, kill
tumor cells and block the
growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).
Nagoya University - led research team shows
in mice the potential
of a special immune
cell that targets a key protein
in tumor growth that helps stop brain cancer.
The researchers took this discovery and,
in an animal model, identified a drug that is able to re-activate those immune
cells and reduce brain
tumor growth, thereby increasing the lifespan
of mice two to three times.
Dr. Massagué is particularly interested
in the ability
of tumor cells to hug blood vessels, as he suspects this behavior may be essential for the survival
of metastatic cancer
cells not only
in the brain but also
in other parts
of the body where metastatic
tumor growth can occur.
These findings also have implications for treatment
of cancer and other disorders, such as obesity,
in which M2 macrophage
cells play a regulatory role
in tumor growth and fat deposition.
In mice, the Runx2 knock - in myeloma cells produced greater tumor growth and a wider spread of disease compared with the original myeloma cells; conversely, the Runx2 knock - down cells had less tumor growth and disease sprea
In mice, the Runx2 knock -
in myeloma cells produced greater tumor growth and a wider spread of disease compared with the original myeloma cells; conversely, the Runx2 knock - down cells had less tumor growth and disease sprea
in myeloma
cells produced greater
tumor growth and a wider spread
of disease compared with the original myeloma
cells; conversely, the Runx2 knock - down
cells had less
tumor growth and disease spread.
In the last few years, a bulk of data pointing to a small population of cells in tumors that maintain tumor growth, are particularly resistant to chemotherapy, are responsible for relapses, and develop metastase
In the last few years, a bulk
of data pointing to a small population
of cells in tumors that maintain tumor growth, are particularly resistant to chemotherapy, are responsible for relapses, and develop metastase
in tumors that maintain
tumor growth, are particularly resistant to chemotherapy, are responsible for relapses, and develop metastases.
Researchers at the Bellvitge Biomedical Research Institute
of Bellvitge, the Catalan Institute
of Oncology and the University Hospital
of Bellvitge have participated
in an international study published
in the journal Cancer
Cell that describes how exosomes secreted by
tumor cells contain protein and microRNA molecules capable
of transform neighboring
cells into tumoral
cells promoting
tumor growth.
The Campàs lab is studying several
of these questions, including how limbs are built and how mechanical changes
in tumors affect the behavior
of malignant
cells and the
growth of the
tumor.
The researchers also tested a Runx2 knock - down variant
of a human multiple myeloma
cell line and found that it produced significantly less
tumor growth in immunodeficient mice than the original human multiple myeloma
cells.
With these
in vitro test methods, the KU researchers have shown that anti-CD44s antibody can reduce pancreatic cancer
cell growth, metastasis and ability
of the
tumors to recur after radiation therapy.
«Despite the low infection levels
of mouse
cells with oHSV, we were able to cause a delay
in tumor growth in one
of the cancer models and even cure many
of the mice
in a second model,» said first author Jennifer Leddon, who conducted much
of the laboratory work during a research experience
in the Center for Childhood Cancer and Blood Diseases.
«
Tumor cells produce larger quantities
of H2O2 and use oxidative signals at higher levels than normal
cells in order to drive their own
growth,» says Mirko Sobotta, first author
of the publication.
In this study, we found that chloroquine not only has an effect on the growth of the cancer cells, but also makes the tumor environment less aggressive by normalizing the abnormal blood vessels in the tumor,» says Patrizia Agostini
In this study, we found that chloroquine not only has an effect on the
growth of the cancer
cells, but also makes the
tumor environment less aggressive by normalizing the abnormal blood vessels
in the tumor,» says Patrizia Agostini
in the
tumor,» says Patrizia Agostinis.
«About five percent
of people have some kind
of cartilage
tumor in their bones, and
in most cases it's because the
growth - plate cartilage
cells weren't fully replaced by bone tissue,» Alman said.
Scientists now know that what matters most
in determining the behavior
of a particular cancer (and its response to specific therapy) are the molecular pathways that drive malignant
cell growth instead
of where the
tumor begins
in the body.
However, cancer
cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels
of a human colorectal cancer gene
in mice stopped
tumor growth and re-established normal intestinal function within only 4 days.
The substance vigorously inhibited the
growth of cultured
tumor cells from colon, lung, and breast cancers, the team reports
in the 20 January issue
of Angewandte Chemie.
Overexpression
of ZMYND11
in an osteosarcoma
cell line and a triple - negative breast cancer
cell line inhibited
tumor growth.
Multiple myeloma is a cancer
of plasma
cells in the blood that causes
tumor growths in bone marrow.
Damage occurs when metastatic
tumor cells recruit pre-osteoclast
cells to the bone and then induce their differentiation into mature bone - degrading
cells, which results
in the release
of proteins from the bone matrix that promote
tumor cell growth.
The researchers identified a genetic mutation
in the
tumor cells that plays a role
in both the
growth and the death
of a
cell.
«We demonstrated that alpha - KGDH interacts with Gcn5
in the
cell nucleus and found that
tumor cell proliferation and
tumor growth were inhibited when alpha - KGDH was blocked from entering the
cell nucleus or by disruption
of Gcn5's binding to succinyl - coenzyme A,» said Lu.
The idea has been controversial, but three papers published today report evidence that
in certain brain, skin, and intestinal
tumors, cancer stem
cells are the source
of tumor growth.
He and his colleagues report online
in Nature that
in mouse papilloma
tumors, a precursor to skin cancer, most
of the
tumor growth came from a few
cells, which
in some ways resembled the stem
cells that maintain healthy skin.
Epidermal
growth factor receptor (EGFR) mutations found
in the circulating free
tumor DNA (ctDNA) from the plasma
of advanced non-small
cell lung cancer (NSCLC) patients correlates well with the EGFR mutations from patient - matched
tumor tissue DNA.
But it has been harder to test whether cancer stem
cells fuel the
growth of tumors in other tissues.
In fact, associations
of cancer
cells with the normal peritumoral microenvironment can profoundly impact
tumor growth and development.
When the researchers reduced the amount
of IL13RA2 expression
in the cancer
cells, they found that the
tumor growth was significantly slower
in models.
«Osteoporosis drug stops
growth of breast cancer
cells, even
in resistant
tumors, study suggests.»
By blocking these
in lung endothelial
cells, the researchers were able to slow lung
tumor growth in mice and also reduce the spread
of metastatic
tumors.
They found higher levels
of JAK1
in resistant
tumors, which caused increased expression
of epidermal
growth factor receptor (EGFR)-- a receptor tyrosine kinase that promotes
cell proliferation.
By using molecular genetic tools to reduce the amount
of PC
in human lung cancer
cells, the team observed decreased
cell growth, a compromised ability to form colonies
in soft agar (a gelatinous material specifically used to grow bacteria and other
cells), and a reduced rate
of tumor growth in mice.
Unregulated
growth is due
in large part to the fact that
tumor cells can rebuild protective ends
of their chromosomes, which are made
of repeated DNA sequences and proteins.
«You can see they are very active and affect the DNA
in the
tumor tremendously, causing lots
of mutations that may further the
cells» uncontrolled
growth, says Alon Keinan, a computational biologist at Cornell University.
Drugs like fluorouracil, oxaliplatin and irinotecan work by mimicking and damaging DNA molecules, or inhibiting enzymes involved
in cell and DNA replication, slowing the uncontrolled
growth of tumor cells.
Joining forces with dermatologists and oncologists from the University Hospital
in Zurich and backed by the University Research Priority Program «Translational Cancer Research,» Sommer's team was able to demonstrate that,
in melanoma
cells, the epigenetic factor EZH2 controls genes that govern
tumor growth as well as genes that are important for the formation
of metastases.