Sentences with phrase «growth of tumour cells»

Not exact matches

Although these spots themselves are harmless, if some of the spots are bigger than a 50 cent coin, then it could be due to Neurofibromatosis (NF), which is a genetic disorder of the nervous system that causes abnormal cell growth of nerve tissues or benign tumours to form on the nerves anywhere in the body at any time.

PTEN is known as a tumour suppressor gene meaning that it typically slows the growth of cells and its loss can lead to cancer.

That now appears to be because they prompt the growth of the very tumour cells they are meant to kill.

They conclude that the sperm made by these cells contained the disease - linked mutations and that the mutations may be driving the growth of the tumours (Nature Genetics, DOI: 10.1038 / ng.470).

These «aggregates» can comprise hundreds of thousands of cells, be up to 2 mm in diameter and be eight times more resistant to chemotherapy drugs — firstly because hypoxic conditions are created inside the aggregates and secondly because these tumour cells reduce growth and are therefore less sensitive.

But as inflammation is known to promote the growth of cancer, they assumed that the cells were helping the tumours to grow.

The researchers hope that ultimately human trials will prove the efficacy of the OH14 compound in sensitising tumour cells and cancer stem cells to existing drug - based therapies thus disabling tumours from seeding new growth after treatment.

«In most cases we think the body's growth control mechanisms eventually stop the cells from proliferating further, but in occasional cases where additional mutations occur in the clump of cells, a tumour will eventually develop,» says Andrew Wilkie also of the University of Oxford, who supervised the work.

They concluded that the sperm made by these cells contained the disease - containing mutations and that the mutations may be driving the growth of the tumours.

There is a growing number of lawsuits against such clinics and a few cases have been reported of tumours or excessive tissue growth (see «Ongoing stem cell trials» below).

«Shutting off vital tumour growth processes can lead to the death of human brain tumour - initiating cells.

Cancer stem cells are strongly associated with the growth and recurrence of all cancers and are especially difficult to eradicate with normal treatment, which also leads to tumours developing resistance to other types of therapy.

Such a drug would block only the androgen receptor in prostate cells, and so stop the chain of reactions leading to further tumour growth, says McCague.

The experimental drug cediranib blocks the cell surface receptor VEGF, which stimulates the growth of new blood vessels to feed the growth of tumours,» explains study researcher Dr Paul Symonds, of the Department Cancer Studies & Molecular Medicine at the University of Leicester, UK.

Samples of tumours from bowel cancer patients given different doses of resveratrol showed that even lower doses can get into cancer cells and potentially affect processes involved in tumour growth.

For example, if your topic is a gene that controls cancer cells, a description of sinister tumour growth in the relevant organ will probably do the trick.

A team working at the Institute of Cancer Research and the Royal Marsden Hospital in London, in collaboration with scientists at the National Cancer Institute in Bethesda, Maryland, has found that tamoxifen also works by encouraging the cells surrounding a tumour to produce a «growth factor».

Cancer stem cells, which fuel the growth of fatal tumours, can be knocked out by a one - two combination of antibiotics and Vitamin C in a new experimental strategy, published by researchers at the University of Salford, UK.

«We have identified a number of pharmaceutical compounds that selectively inhibit — in different experimental models — the mitochondrial enzyme responsible for the tumour growth, thus limiting fat synthesis and without harming normal cells.»

They found that the drug increased the level of lactate in cells and, more importantly, reduced tumour growth.

Scientists have identified for the first time the «cell of origin» — in other words, the first cell from which the cancer grows — in basal cell carcinoma, the most common form of skin cancer, and followed the chain of events that lead to the growth of these invasive tumours.

In the future, scientists hope to target stem - cell - like cells within cancers that may be responsible for most of the growth of some tumours, and evade existing drugs.

Tamoxifen prevents oestrogen from stimulating growth of breast cancer cells but some tumours can eventually develop resistance to the treatment, making the drug ineffective.

For analysis of tumour growth over time, 1 × 106 B16F10 luciferase - positive cells were injected s.c. into the right flank of mice.

«I originally trained as a developmental biologist, then, during my postdoc in stem cell biology, I became interested in research showing that the growth of brain tumours might be driven by cells similar to neural stem cells.

Tumour cells are «glutamine - addicted» [1,2] because glutamine is coupled to mechanistic target of rapamycin (mTOR) signalling, which integrates signals from growth factors, energy status and amino acid nutrition and co-ordinates these signals with cell growth, cell cycle progression and antioxidant machinery [3].

The adenomatous polyposis coli (APC) gene is a tumour suppressor gene, i.e. a gene preventing uncontrolled cell growth that could lead to the formation of a cancer tumour.

The stem cell theory of cancer hypothesizes that «stem - like» cancer cells are responsible for the generation of tumours and for sustaining tumour growth (reviewed in ref.17).

Research has discovered that a compound in parsley could prevent the growth of specific breast cancer tumour cells.

Green tea contains a rich concentration of flavonoids and polyphenols, natural antioxidants that may protect cells from carcinogens (cancer - causing substances) and inhibit tumour growth by helping to neutralise free radicals in the body.

The same thing happens (the inhibition of stated growth factors) with hyperbaric oxygen therapy so it makes sense how all this fits together in powerful synergy to increase metabolic stress on tumour cells.

Fasting cycles retard growth of tumours and sensitise a range of cancer cell types to chemotherapy http://stm.sciencemag.org/content/scitransmed/4/124/124ra27.full

The Journal of Agricultural and Food Chemistry had on its December 2006 issue a report that found the ability of red raspberries to repress the human oral and breast, as well as colon and prostate tumour cell lines growths when they were tested in test tubes.

· Cancer Growth and Spread — Healing Angiogenesis and Metastasis, discussing blood vessel development and growth factors, dysregulation including hypoxia and other blood supply stress responses in cancer and other diseases and how cancer cells travel and invade — metastasis via the complex tumour microenvironment — TME — comprised of immune cells, cytokines, growth factors, reactive oxygen species (ROS) and cancer - associated fibroblast Growth and Spread — Healing Angiogenesis and Metastasis, discussing blood vessel development and growth factors, dysregulation including hypoxia and other blood supply stress responses in cancer and other diseases and how cancer cells travel and invade — metastasis via the complex tumour microenvironment — TME — comprised of immune cells, cytokines, growth factors, reactive oxygen species (ROS) and cancer - associated fibroblast growth factors, dysregulation including hypoxia and other blood supply stress responses in cancer and other diseases and how cancer cells travel and invade — metastasis via the complex tumour microenvironment — TME — comprised of immune cells, cytokines, growth factors, reactive oxygen species (ROS) and cancer - associated fibroblast growth factors, reactive oxygen species (ROS) and cancer - associated fibroblast (CAF);

In summary, perhaps through glucose «starvation» of tumour cells and by reducing the effect of direct insulin - related actions on cell growth, ketogenic diets show promise as an aid in at least some kind of cancer therapy and is deserving of further and deeper investigation — certainly the evidence justifies setting up clinical trials.

As boron is essential for cell membranes and boron deficiency widespread, this may be an important cause for the initiation of tumour growth.

While there are many different types of cancer, all of them stem from the abnormal growth of cells that invade numerous body sites, quickly leading to the formation of tumours that are either benign (restricted to a local area and removable) or malignant (invasive, spreading throughout the body).