To their surprise, they found that these Th17 - deficient mice experienced far more aggressive cancer
growth than normal mice — with the cancer completely smothering the lungs within 16 days.
Not exact matches
By 2003 other scientists had genetically manipulated
mice to be relatively insensitive to either insulin or insulin - like
growth factor; in both cases, the genetically engineered
mice lived significantly longer
than normal mice.
Longo also knew of research by molecular biologist John Kopchick at Ohio University, which showed that
mice with a mutation in their
growth hormone receptor gene lived 40 percent longer
than normal mice — the equivalent of an average American living to age 110.
Experiments on
mice and on heart cells obtained from infants born with congenital heart disease suggest that neuregulin 1, a human
growth factor, can put infant heart cells on a path that mimics
normal growth rather
than stalling out.
One, called CISH, shuts down the receptor to a key
growth hormone;
mice that overproduce the receptor are smaller and grow more slowly
than normal.
He notes, however, that other attempts to stimulate bone
growth in
mice by manipulating cell signaling proteins have produced denser
than normal bones — and he's surprised that Helms's team didn't see the same.
As seen through a microscope, the leg bone of a
normal mouse (left) makes considerably less new bone
than a
mouse that produces high levels of a signaling protein, WNT7B, that stimulates new bone
growth (shown in pink on the right).
from mprize.org «Dwarf
mice... lack
growth hormone (GH), prolactin (PRL), and thyroid - stimulating hormone (TSH), (and) live much longer
than their
normal siblings, and exhibit many symptoms of delayed aging.»