Sentences with phrase «guanine nucleotides»

As expected, the mutational spectrum was enriched for G - > T and C - > A changes associated with adduct formation on guanine nucleotides induced by benzopyrene, the chemical mutagen found in tobacco smoke.

Furthermore, by adding guanine nucleotides at the end of sgRNA (single guided RNA) that composes CRISPR - Cas9, they have successfully created this highly - developed programmable nuclease, which has no measurable off - target effects in the human genome.

Here, two ER to Golgi v - SNAREs, Bet1p and Bos1p, were shown to interact specifically with Sar1p, Sec23p, and Sec24p, components of the COPII coat, in a guanine nucleotide — dependent fashion.

The two receptors are homologous with each other, rhodopsin, and other receptors coupled to guanine nucleotide regulatory proteins and they contain seven hydrophobic domains, which may represent transmembrane spanning segments.

Heterotrimeric guanine nucleotide - binding regulatory proteins (G proteins) dissociate into guanosine triphosphate (GTP)- bound alpha subunits and a complex of beta and gamma subunits after interaction with receptors.

The specificity for coupling to the stimulatory guanine nucleotide regulatory protein lies within a region extending from the amino terminus of the fifth hydrophobic domain to the carboxyl terminus of the sixth.

The β2 - adrenergic receptor (β2AR) is a well - studied prototype for heterotrimeric guanine nucleotide — binding protein (G protein)-- coupled receptors (GPCRs) that respond to diffusible hormones and neurotransmitters.

In place of rungs, the twisting, four - sided tower has platforms with a guanine nucleotide on each of four corners, hence the name G - quadruplex.

They found that methylation levels correlated with Alzheimer's disease in 71 of 415,848 CpG markers analyzed (these are a pair of DNA building blocks consisting of a cytosine and a guanine nucleotide that are located next to each other).

β - Arrestins, originally discovered in the context of heterotrimeric guanine nucleotide binding protein — coupled receptor (GPCR) desensitization, also function in internalization and signaling of these receptors.

Hormones and neurotransmitters may mediate common responses through receptors that couple to the same class of heterotrimeric guanine nucleotide — binding (G) protein.

Heterotrimeric guanine nucleotide — binding protein (G protein)-- coupled receptors constitute the largest family of eukaryotic signal transduction proteins that communicate across the membrane.

The guanine nucleotide exchange factor (GEF) for Rho, p115 RhoGEF, has an amino - terminal region with similarity to RGS proteins.

P - Rex2, a Rac - guanine nucleotide exchange factor, is expressed selectively in ribbon synaptic terminals of the mouse retina.

The presence of a guanine nucleotide at rs9349379 was associated with higher levels of the endothelin - 1 precursor protein produced by EDN1, as well as higher rates of coronary artery disease and lower rates of migraine headache, cervical artery dissection, fibromuscular dysplasia, and hypertension.

The researchers zeroed in on a single - nucleotide polymorphism (SNP) that appeared to be the causal mutation, typically consisting of an adenine nucleotide but appearing as a guanine nucleotide in roughly a third of the population, located in a region of noncoding DNA that falls within the PHACTR1 gene.

In the JBC article, Lipschutz and his MUSC coauthors go a step further — showing in cell culture and a zebrafish model that depletion of Tuba, a guanine nucleotide exchange factor required for Cdc42 activation, also disrupts renal ciliogenesis.

The Cdc42 guanine nucleotide exchange factor FGD6 coordinates cell polarity and endosomal membrane recycling in osteoclasts.

CpG, regions of DNA in which a cytosine nucleotide occurs next to a guanine nucleotide separated by only one phosphate; TNF, Tumor necrosis factor; SES, socioeconomic status; DMR, Differentially methylated Region

Not exact matches

The five nucleotides — adenine, thymine, cytosine, guanine and uracil — arranged into DNA and / or RNA The twenty amino acids — that form all proteins, including enzymes and the other 100,000 or so proteins in a complex organism's body.

There are four different nucleotides: adenine, thymine, cytosine and guanine.

DNA is made of four substances — the nucleotide bases adenine, guanine, thymine, and cytosine — that will combine only in specific configurations and sequences.

In this case, the change is subtle: A single nucleotide called an adenine is replaced by another called a guanine on human chromosome 12.

Such statements do not begin to address the conditions and processes that led to the assembly of the nucleotides — adenine, guanine, cytosine, thymine and uracil — nor do the statements indicate that the materials necessary to form the nucleotides might be present in hydrothermal vents.

In some sequences, they systematically changed purine RNA nucleotides, containing the bases adenine or guanine, into the corresponding DNA purines.

The most commonly used form of Cas9, derived from the bacteria Streptococcus pyogenes and known as SpCas9, recognizes PAM sequences in which any nucleotide is followed by two guanine DNA bases.

Working with French composer Richard Krüll, the pair turned the complete nucleotide sequences of several microbe genes into compositions based on DNA bases: A (adenosine), C (cytosine), G (guanine), and Thymine (which they have translated to «Re,» or D).

The tests look for differences in the DNA nucleotides adenosine, thymine, guanine, and cytosine (A, T, G, and C — the letters of the genetic code) between one person and another, or between one group of people and another group.

The technique of DNA origami capitalizes on the simple base - pairing properties of DNA, a molecule built from the four nucleotides Adenine (A), Thymine (T) Cytosine (C) and (Guanine).

New nucleotides — adenine, cytosine, guanine or thymine — are filled into the gaps on the other side of the backbone, pairing with their counterparts (adenine with thymine and cytosine with guanine) and replicating the DNA to make a copy for both the old and the new cells.

Disruption of oligomerization induces nucleocytoplasmic shuttling of leukemia - associated rho Guanine - nucleotide exchange factor.

DNA is made up of only 4 different genetic building blocks called nucleotides, which are named cytosine ©, guanine (G), adenosine (A) and thymidine (T).

Our genetic information is encoded by the nucleotides thymine, cytosine, guanine, and adenosine, abbreviated as T, C, G, and A, respectively.

Probes with a mean detection P value of > 0.01, non-cytosine guanine dinucleotide (CpG) probes, Y - chromosome probes, and 65 single nucleotide polymorphism (SNP) probes were removed.

The researchers analyzed hundreds of human transcription factors, which are proteins that read the genetic information coded in DNA's sequence of four nucleotide bases — adenine (A), cytosine (C), guanine (G) and thymine (T)-- and pass that on to RNA molecules.

In a normal, working copy of the gene, there is a section containing a pattern of three DNA nucleotides — guanine, adenine, adenine (GAA)-- repeated up to about 20 times.

With four different nucleotides comprising our genetic code (adenine, guanine, cytosine, and thymine), the barcodes are long enough to be distinct from other stretches of DNA in the genome, and also allow for the generation of a seemingly limitless number of codes.

Rabacfosadine is a pro-drug of the nucleotide analog 9 -(2 - phophonylmethoxyethyl) guanine (PMEG) that selectively targets lymphoid cells and inhibits DNA synthesis.

Colored stripes represent thymine, cytosine, adenine, guanine — the four nucleotides that make up DNA.