Its lead product candidate includes plecanatide a phase 3
guanylate cyclase C, or GC - C, receptor agonist, designed to treat GI disorders, primarily chronic idiopathic constipation, or CIC, and constipation - predominant irritable bowel syndrome, or IBS - C.
Magnesium is a cofactor for several important enzymes in the body, like DNA / RNA polymerases, used to transcribe new DNA / RNA strands, and
guanylate cyclase, used to regulate the movement of minerals across cell membranes.
Research Interests: Inflammation; Nitric oxide; Heme transport; Soluble
guanylate cyclase; Electron transfer
Probing further, the authors of the study also revealed that Aipl1 is critical for the stability of two enzymes — the cGMP - phosphodiesterase 6 and
the guanylate cyclase - which mediate phototransduction, the process of converting light into an electrical signal.
Probing further, the authors of the study also revealed that Aipl1 is critical for the stability of two enzymes — the cGMP - phosphodiesterase 6 and
the guanylate cyclase — which mediate phototransduction, the process of converting light into an electrical signal.
A team of French and American scientists at several institutes pinpointed mutations in the retinal
guanylate cyclase (RETGC) gene in eight families in which the disease has struck.
The characteristics of this phenomenon paralleled those of the activation of
guanylate cyclase by nitric oxide, which is a component of tobacco smoke.
Cigarette smoke activates
guanylate cyclase and increases guanosine 3», 5» - monophosphate in tissues