Sentences with phrase «guanylyl cyclase»

His doctoral research focused on the regulation of the ERK / MAPK pathway by adenylyl cyclases during long - term memory formation and sensitization to drugs of abuse.

The alpha 2 and beta 2 adrenergic receptors, both of which are activated by epinephrine, but which can be differentiated by selective drugs, have opposite effects (inhibitory and stimulatory) on the adenylyl cyclase system.

In the presence of Gs alpha, the alpha subunit of the G protein that activates adenylyl cyclase, one form of adenylyl cyclase was inhibited by beta gamma, some forms were activated by beta gamma, and some forms were not affected by beta gamma.

This resulted in increased basal myocardial adenylyl cyclase activity, enhanced atrial contractility, and increased left ventricular function in vivo; these parameters at baseline in the transgenic animals were equal to those observed in control animals maximally stimulated with isoproterenol.

G protein beta gamma subunits have been found to have regulatory effects on certain types of adenylyl cyclase.

The plasma membrane of hepatic parenchymal cells contains an adenyl cyclase system that is stimulated by glucagon.

Adrenocorticotropin and epinephrine do not stimulate this adenyl cyclase, and very little cyclic phospho - diesterase activity is present in the membrane.

These findings support the concept that glucagon exerts its regulatory action in the liver by stimulating adenyl cyclase activity in the plasma membrane.

A complementary DNA clone encoding the alpha subunit of the adenylate cyclase stimulatory G protein (Gs) was isolated and identified.

Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase

Concentration - dependent inhibition of adenylyl cyclases by purified Gi alpha subunits is described.

Although type I adenylyl cyclase is inhibited directly by exogenous beta gamma, inhibition of adenylyl cyclase by Gi alpha has not been convincingly demonstrated in vitro.

An adenylate cyclase that is activated specifically by very low concentrations of octopamine has been identified both in homogenates and in intact cells of the thoracic ganglia of an insect nervous system.

This enzyme appears to be distinct from two other adenylate cyclases present in the same tissue, which are activated by dopamine and by 5 - hydroxytryptamine, respectively.

The concentrations of Gi alpha required to inhibit adenylyl cyclase were substantially higher than those normally thought to be relevant physiologically.

Octopamine - Sensitive Adenylate Cyclase: Evidence for a Biological Role of Octopamine in Nervous Tissue

The characteristics of the inhibitory effect were dependent on the type of adenylyl cyclase and the nature of the activator of the enzyme.

An adenyl cyclase activated by low concentrations of dopamine has been found in the mammalian superior cervical sympathetic ganglion.

Cigarette smoke activates guanylate cyclase and increases guanosine 3», 5» - monophosphate in tissues

The characteristics of this phenomenon paralleled those of the activation of guanylate cyclase by nitric oxide, which is a component of tobacco smoke.

Adenylyl cyclase (AC) converts adenosine triphosphate (ATP) to cyclic adenosine monophosphate, a ubiquitous second messenger that regulates many cellular functions.

Desensitized beta - adrenergic receptors showed a 40 to 50 percent reduction in their ability to couple to the heterologous adenylate cyclase system, comparable to the reduction in their functionality observed in their original membrane environment.

The whole - cell current response to glutamate and kainate [a non-NMDA (N - methyl - D - aspartate) receptor agonist] was enhanced by forskolin, an activator of adenylate cyclase.

Studies of glutamate receptor channels expressed in cultured hippocampal pyramidal neurons reveal that these channels are subject to neuromodulatory regulation through the adenylate cyclase cascade.

A team of French and American scientists at several institutes pinpointed mutations in the retinal guanylate cyclase (RETGC) gene in eight families in which the disease has struck.

Probing further, the authors of the study also revealed that Aipl1 is critical for the stability of two enzymes — the cGMP - phosphodiesterase 6 and the guanylate cyclase — which mediate phototransduction, the process of converting light into an electrical signal.

Probing further, the authors of the study also revealed that Aipl1 is critical for the stability of two enzymes — the cGMP - phosphodiesterase 6 and the guanylate cyclase - which mediate phototransduction, the process of converting light into an electrical signal.

Both CB1 and D2 receptors couple to Gi - o proteins and inhibit adenylyl - cyclase, whereas their costimulation results in Gs protein - dependent activation of adenylyl - cyclase (44, 45).

Research Interests: Inflammation; Nitric oxide; Heme transport; Soluble guanylate cyclase; Electron transfer

As a postdoctoral fellow, he worked with Nobel laureate Alfred Gilman, and purified and characterized the inhibitory component of adenylate cyclase, Gi.

The newly developed CB1 receptor selective antagonist SR141716A was found to reverse cannabinoid agonist (WIN55212 - 2 or CP55940)- induced adenylyl cyclase inhibition.

Pituitary adenylate cyclase activating polypeptide (PACAP) signalling exerts chondrogenesis promoting and protecting effects: implication of calcineurin as a downstream target.

Adenylyl Cyclase Type 5 (AC5): Knockout of AC5 extends life in mice, with the most plausible mechanism being increased resilience of the cardiovascular system to the various slings and arrows of aging.

The Groups II and III of glutamate receptor membranes are coupled to the intracellular G - protein subunit, these mediate the inhibition of adenylyl cyclase [40, 41].

N terminus of type 5 adenylyl cyclase scaffolds Gs heterotrimer.

Pituitary Adenylate Cyclase - activating Peptide (PACAP) Recruits Low Voltage - activated T - type Calcium Influx under Acute Sympathetic Stimulation in Mouse Adrenal Chromaffin Cells.

Dimerization of mammalian adenylate cyclases.

The primary source of cyclic GMP in the intestinal lining is called Guanylyl - cyclase C (GCC).

Scaffolding by A-kinase anchoring protein enhances functional coupling between adenylyl cyclase and TRPV1 channel.

Some candidate virulence factors present in UM270 genome were detected and found to perform the following putative functions: a 3 - oxoacyl -[acyl - carrier - protein], catalase, capsule polysaccharide export, endoglucanase, cyclolysin secretion ATP - binding protein and diguanylate cyclase.

The effects of prior stress on anxiety - like responding to intra-BNST pituitary adenylate cyclase activating polypeptide in male and female rats King SB, Lezak KR, O'Reilly M, Toufexis DJ, Falls WA, Braas K, May V, Hammack SE.

Molecular cloning has demonstrated that dunce codes for the enzyme, cAMP phosphodiesterase; rutabaga codes for adenylyl cyclase; DCO codes for the catalytic subunit of protein kinase A, and CREB a transcription factor that is phosphorylated and activated by protein kinase A.

Called adenylate cyclase 3 (ADCY3), the gene codes for a protein known to be related to appetite control and our sense of smell.

Gi - coupled GPCR receptors, however, inhibit adenylyl cyclase and cAMP production.

Hui - Chen Lu, Wei - Chi She, Daniel T. Plas, Paul E. Neumann, Roger Janz, Michael C. Crair (2003) «Adenylyl cyclase I regulates AMPA receptor trafficking during mouse cortical «barrel» map development», Nature Neuroscience, 6: 939 - 947.

Activated heterotrimers have a wide array of effectors including adenylate cyclase (AC), phospholipase C - beta, PI 3 - kinases, GIRK channels and RhoA

Upon ligand binding, the Gs - coupled GPCR receptor activates adenylyl cyclase that in turn produces cAMP, governing important cellular responses.

Clary Sage extract - Clary sage is also known as Salvia Sclarea, which is a potent adenylate cyclase activator - meaning that it increases the enzyme action of forming cylic AMP (cAMP - cyclic adenosine monophosphate) from ATP.

Magnesium is a cofactor for several important enzymes in the body, like DNA / RNA polymerases, used to transcribe new DNA / RNA strands, and guanylate cyclase, used to regulate the movement of minerals across cell membranes.

Phen375 uses it to activate adenylyl cyclase and to raise cyclic AMP levels in your body cells.