Sentences with phrase «guardian of the genome»
«Through further functional studies we found that myosin IIa is also required for activation of the main guardian of the genome — a tumor suppressor protein called p53.»
sciencedaily.com
Indeed, a plethora of research reports has implicated the master guardian of the genome, p53, as being a major hindrance to the iPS induction process [33]--[38].
The finding shows that p53, sometimes described as the «guardian of the genome», has been around for over 1 billion years.
P53, often mutated in cancer cells, is known as «guardian of the genome,» because it can promote DNA repair or arrest growth in response to DNA damage.
Called p53, the protein sounds the alarm to kill cells with DNA damage and prevent them from becoming cancerous — one reason why it has been called the «guardian of the genome.»
Topping the list was p53, a protein often called the «guardian of the genome» because it causes damaged, out of control cells to commit suicide, or apoptosis, which reduces the likelihood that they will go on to form tumors.
MDM2 is also a well - known regulator of «guardian of the genome» p53.
Nicknamed the «guardian of the genome,» p53 controls cell growth and cell death.
P53 is known as the «guardian of the genome.»
Previously described as the «guardian of the genome» and voted «Molecule of the Year» in 1993, p53 is one of the most important proteins regulating cell growth and a major focus for oncology research.
«Histone 1, the guardian of genome stability.»
LA JOLLA, CA — A collaborative study by researchers at the Salk Institute for Biological Studies uncovered that the tumor suppressor p53, which made its name as «guardian of the genome,» not...
It found that the p53 tumor suppressor gene, the «guardian of the genome,» interacts with another gene, p21, to arrest growth of stressed cells.
Teodoro JG, Evans SK and Green MR. Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome.
p53 - Based cyclotherapy: exploiting the «guardian of the genome» to protect normal cells from cytotoxic therapy.