Sentences with phrase «guide axons»

«This is the first biological validation of a computational model developed in the early 1980s that suggested that two such forces would be necessary to guide axons as they establish the connections that relay spatial information from one part of the nervous system to another,» said study author Yimin Zou, PhD, assistant professor of neurobiology at the University of Chicago.

Today a rising star in neuroscience at the University of Chicago, Zou made a name for himself by being the first to discover the molecular signals that guide axons longitudinally along the spinal cord, toward or away from the brain.

So, for example, the signal that tells the axon to turn — which should disappear after the turn is made — remains active, interfering with new signals meant to guide the axon in other directions.

Eager to establish himself, he chose a natural extension of the work he did with Tessier - Lavigne: identifying the molecular cues that guide axon growth toward and away from the brain.

In neural development, Semaphorin 3B (SEMA3B) is thought to play a role in guiding axons by repulsion.

Not exact matches

The way that an axon guides and finds its proper target is through so - called growth cones located at the tips of axons.

The nervous system further directs these wandering axons by placing guide cells along their path.

Without a viable partner the axon would die; the guide cells form temporary synapses with the axons until the intended target is found.

«There must be some genes that are necessary and possibly also sufficient to guide the chandelier cell axons to this subcellular target,» said Andre Steineke, Ph.D., Postdoctoral Researcher and lead author on the study.

The idea of the implants is to create tiny conduits to guide formation of new nerve fibres, or axons, across this fluid - filled space.

Glia guide pioneer and follower axons using distinct signals.

Although Wnts were better known because of their role as morphogens — proteins that pattern bodily structures and determine cell fates — Zou recently showed how members of the Wnt family served to guide pathfinding axons up and down the spinal cord by attracting or repelling receptors on the growth cones of sensory or motor nerves.

Abstract Brain assembly is hypothesized to begin when pioneer axons extend over non-neuronal cells, forming tracts guiding follower axons.