Not exact matches
In this latest advance reported in PNAS, the Wyss team showed that the human
gut - on - a-chip's unique ability to co-culture intestinal cells
with living microbes from the normal
gut microbiome for an extended period of time, up to two weeks, could allow breakthrough insights into how the
microbial communities that flourish inside our GI tracts contribute to human health and disease.
In addition, cohousing coprophagic mice harboring transplanted microbiota from discordant pairs provides an opportunity to determine which bacterial taxa invade the
gut communities of cage mates, how invasion correlates
with host phenotypes, and how invasion and
microbial niche are affected by human diets.
Using a combination of high throughput methods, we have been able to assess the ecology of microbes and functional pathways in these
communities to correlate
microbial and functional abundances of the
gut microbiome
with host genotype / phenotype.
While the jury's out on whether these supplements have any effect on the
gut's bacterial environment, it is clear that not having a thriving
microbial community in one's intestines can be dangerous,
with consequences ranging from a day or two of diarrhea to life - threatening infection
with a nasty bug called Clostridium difficile, which can gain a foothold in patients treated
with antibiotics.