Not exact matches
To find out what was going on in the
microbiomes of four sets of differently shaped identical twins, researchers transferred some
gut bacteria from a lean (human) twin to a sterile mouse: one with no foreign bacteria
at all.
I agree and you know that emulsifiers are
gut microbiome killers causing the
gut to look like IBD or metabolic syndrome,
at least in mice for now!
Experts are realizing the importance of a well - balanced
microbiome (the collection of bacteria your baby inherits
at birth) because it literally sets the stage for your overall
gut and immune system health for years to come.
«Further studies are needed to delineate if specific changes in maternal diet during breast - feeding alter the infant
gut microbiome and to determine if this results in any health consequences for the infant,» said Kristen Meyer, in the Department of Obstetrics and Gynecology
at Baylor College of Medicine and the presenter of the study
at the SMFM annual conference.
In a study to be presented Thursday, Jan. 26, in the oral plenary session
at 1:15 p.m. PST,
at the Society for Maternal - Fetal Medicine's annual meeting, The Pregnancy Meeting ™, researchers with Baylor College of Medicine, Houston, Texas and University of California, San Diego, La Jolla, California, will present their findings on a study titled, Maternal Diet Structures the Breast Milk
Microbiome in Association with Human Milk Oligosaccharides and
Gut - Associated Bacteria.
Although only ten women were followed, it is intriguing that the breast milk
microbiome of women delivering via planned Cesarean
at birth, one month, and six months post-birth, was more similar to their
gut microbiome than the breast milk of mothers who delivered vaginally [4].
Oligosaccharides in breast milk are thought to promote Bifidobacterium growth, 35 and decreased Bifidobacterium in infancy has been found to be associated with an increased risk for being overweight
at age 10 years.36 Many formulas are supplemented with prebiotics such as short - chain galacto - oligosaccharides and long - chain fructo - oligosaccharides that increase the overall representation of Bifidobacterium in the
microbiome of formula - fed infants, and similar to breast milk, promote lactate and short - chain fatty acid prevalence in the infant
gut (reviewed in the study by Oozeer et al37).
In another animal
microbiome experiment, Jeffrey Gordon, a biologist
at Washington University in St. Louis, took a suite of microbes from the
guts of both obese and lean mice and transplanted them into the
guts of microbe - free mice.
Through projects
at Duke Health, DCRI and the Duke Center for Childhood Obesity Research, Armstrong and other Duke scientists are assessing the most effective strategies to reduce obesity in children, including programs that offer
at - risk children access to free medical care, partnerships with municipal recreation programs across North Carolina, and even studying children's
gut bacteria to determine how the
gut microbiome is related to weight.
Nevertheless, carefully regulated probiotics, which introduce nonpathogenic competitors to disease, could be effective
at balancing the
gut microbiome.
But
at least one procedure that allows doctors to manipulate the
gut microbiome is already here.
The researchers sampled participants»
gut microbiomes again
at the end of the exercise program and after another six weeks of sedentary behavior.
By chemically removing the
gut microbiome in zebrafish in the lab and then repopulating the
gut with two to three bacterial species, University of Oregon biologist Karen Guillemin has shown that certain microbes are especially skilled
at suppressing the host immune system and preventing inflammation — a discovery she thinks may have implications for human health.
A new study from researchers
at the University of Alabama
at Birmingham shows that Parkinson's disease, and medications to treat Parkinson's, have distinct effects on the composition of the trillions of bacteria that make up the
gut microbiome.
To investigate, researchers from the Channing Division of Network Medicine
at Brigham and Women's Hospital, led by Amir Bashan, PhD, and Yang - Yu Liu, PhD, analyzed data from large metagenomic datasets (e.g. the Human
Microbiome Project and Student
Microbiome Project) to look
at the dynamics of the
gut, mouth and skin
microbiomes of healthy subjects.
«Every human carries trillions of bacteria in their
gut (
gut microbiome) and recent advances in research indicate that these tiny passengers play an important role in our overall health maintenance,» says Ashutosh Mangalam, PhD, assistant professor of pathology
at the University of Iowa Carver College of Medicine.
«The intestinal bacteria, or «
gut microbiome,» you develop
at a very young age, can have a big impact on your health for the rest of your life,» said the study's lead author Dan Knights, a University of Minnesota assistant professor in the Department of Computer Science and Engineering and the Biotechnology Institute.
«Most studies looking
at benefits from soluble corn fiber are trying to solve digestion problems, and we are the first to determine that this relationship of feeding certain kind of fiber can alter the
gut microbiome in ways that can enhance health,» Weaver said.
In the review, Amanda Forde, PhD, and Colin Hill, PhD, of the APC
Microbiome Institute
at University College Cork, in Ireland, note that phages have complex relationships with bacteria in the
gut that could affect health and disease.
«Greater diversity of bacteria in the
gut microbiome is associated with both a higher response rate to treatment and longer progression - free survival,» said study leader Jennifer Wargo, M.D., associate professor of Surgical Oncology
at MD Anderson.
Researchers
at the University of Illinois
at Chicago College of Medicine report that in a mouse model of ALS, the compound butyrate helped correct a
gut microbiome imbalance and reduced
gut leakiness — both symptoms of ALS.
«We set out to find out about human genes that are implicated in the regulation of the
gut microbiome, and we found some that are,» says senior author Ruth Ley, an Associate Professor in the Department of Microbiology
at Cornell University and the study's senior author.
«In the future, such efforts could allow us to much better understand human -
microbiome interactions, model malnutrition disorders and inflammatory diseases of the
gut, and perform personalized drug testing,» said co-first author Alessio Tovaglieri, a Graduate Student
at the Department of Health Science and Technology
at ETH Zurich in Switzerland, who performs his thesis work on Ingber's team.
(American
Gut is a crowd - sourced project aimed
at characterizing the human
microbiome by the Rob Knight Lab
at the University of California San Diego.)
«This tells us the
microbiome has relevance beyond the
gut, and that it is a potential biomarker for asthma,» said Dr. David Perkins, professor of medicine and surgery
at UIC, who jointly operates the lab with Finn.
Scientists
at the Science Foundation Ireland - funded APC
Microbiome Institute
at University College Cork, Ireland, have shown that,
at least in mice,
gut bacteria play a key role in regulating abdominal pain and its associated changes in the brain and spinal cord.
The work also highlights a connection between
gut microbes and brain function that scientists are only just beginning to understand, says Ted Dinan of the
Microbiome Institute
at the University College Cork, Ireland.
Researchers
at Harvard Medical School and Columbia University in the United States have developed a way to study the functions of hard - to - grow bacteria that contribute to the composition of the
gut microbiome.
Michael Blaut, a microbiologist
at the German Institute of Human Nutrition in Potsdam, Germany, says the mouse data are «believable and remarkable,» but says he has a hard time imagining a mechanism that would account for three compounds as chemically different as aspartame, saccharin, and sucralose leading to the same changes in the
gut microbiome.
The
gut microbiome is the population of microbes living within the human intestine, consisting of tens of trillions of microorganisms (including
at least 1,000 different species of known bacteria).
To detect NAFLD earlier and more easily, researchers in the NAFLD Research Center
at University of California San Diego School of Medicine, Human Longevity, Inc. and the J. Craig Venter Institute report that the unique microbial makeup of a patient's stool sample — or
gut microbiome — can be used to predict advanced NAFLD with 88 to 94 percent accuracy.
Researchers
at the University of Montreal, in Canada, have characterized the
gut microbiome of the Canadian Arctic Inuit for the first time.
«We found that when you perturb
gut microbes early in life among mice and then stop the antibiotics, the microbes normalize but the effects on host metabolism are permanent,» says senior author Martin Blaser, MD, the Muriel G. and George W. Singer Professor of Translational Medicine, director of the NYU Human
Microbiome Program, and professor of microbiology
at NYU School of Medicine.
«Our stomachs produce gastric acid to kill ingested microbes, and taking a medication to suppress gastric acid secretion can change the composition of the
gut microbiome,» said senior author Bernd Schnabl, MD, associate professor of gastroenterology
at UC San Diego School of Medicine.
HEIDELBERG, 11 March 2015 — Researchers
at Harvard Medical School and Columbia University in the United States have developed a way to study the functions of hard - to - grow bacteria that contribute to the composition of the
gut microbiome.
Rob Knight is a computational biology pioneer, co-founder of the American
Gut Project and director of the new
Microbiome Initiative
at the University of California, San Diego.
The explosion of
microbiome science has also fuelled a gold rush among companies and individuals offering dietary advice, self - help books aimed
at targeting our
gut microbes, and probiotics, which are foods or supplements that contain live bacteria and yeasts.
We would like to go even smaller, and compress these capabilities into a pill that you could swallow so you could analyze the human
microbiome — or metabolome or even the proteinome —
at any point in the
gut.
Seres Therapeutics, Inc. (NASDAQ: MCRB) today announced that new preclinical data supporting the development of
microbiome therapeutics for immuno - oncology (leveraging
gut microbiota to impact tumor immunotherapy) 1 will be presented today by Sceneay et al in the late breaking poster session
at the 2018 American Association for Cancer Research Annual Meeting (AACR) in Chicago.
Embriette Hyde, project manager
at the American
Gut Project, points out that it can be very challenging to isolate the roles of individual microbes within the «complex tangle» of
microbiomes.
Luis Pedro Coelho and his colleagues
at the European Molecular Biology Laboratory, in collaboration with Nestlé Research, studied the
gut microbiome (the genetic material belonging to the microbiota) of beagles and retrievers.
At PNNL, she leads research into the
microbiome, a term for the collective communities of microbes that reside in many environmental niches, including the human
gut and soil.
Another study from Sweden even demonstrated that the specific
microbiome composition occurring in Alzheimer's patients induces the development of disease - specific amyloid - beta plaques, thereby establishing a direct functional link between the
gut microbiome and Alzheimer's disease —
at least in mice.
The
gut microbiome — a collection of bacteria and other microbes in the
gut — could be a highly accurate predictor of hospitalizations for patients with cirrhosis, according to a recently published study led by a researcher
at Virginia Commonwealth University.
Multi-site human
microbiome Review: The Vagus Nerve
at the Interface of the Microbiota -
Gut - Brain Axis.
Bile acids
at the cross-roads of
gut microbiome - host cardiometabolic interactions.
The new paper, titled «Using Machine Learning to Identify Major Shifts in Human
Gut Microbiome Protein Family Abundance in Disease,» was presented last month
at the IEEE International Conference on Big Data.
She's looking
at the
gut microbiome and how it might influence how effective a drug is or how safe it is.
Herein we propose a variant of Koch's postulates, aimed
at providing a framework to establish causation in
microbiome studies, with a particular focus on demonstrating the health - promoting role of the commensal
gut microbiota.
Krautkramer et al.
at the University of Wisconsin - Madison demonstrate in this study that the
gut microbiome regulates global histone acetylation and methylation not only in the colon, but also in tissues outside the
gut (i.e. liver and fat).