Astonishingly, when germ - free mice are colonized with
the gut microbiota from genetically obese mice (ob / ob), the otherwise lean mice dramatically increase body weight.
This is a visualization of the process of transferring
gut microbiota from wild mice to laboratory mice.
After seeding each reactor with a previously studied microbiome, and opening the setup to the acid whey and its own rich assortment of bacteria (such as common
gut microbiota from the Lactobacillus family), caproic acid, caprylic acid, and other minor products could be continually extracted over a period of several months.
The scientists transferred
gut microbiota from old and young conventional mice to young germ - free mice, and analysed immune responses in their spleen, lymph nodes and tissues in the small intestine.
Not exact matches
«After birth the
gut mucosa is challenged by a myriad of antigens,
from viruses to commensal
microbiota and dietary antigens.
After transferring fecal matter
from one group of rodents to another, they observed similar changes in the
gut microbiota, acetate levels, and insulin.
Prof. Severine Vermeire (KU Leuven / UZ Leuven): «In the future,
gut bacteria may be used to help identify PSC patients with a more or less aggressive disease, or patients that may benefit
from microbiota - based therapies, such as fecal
microbiota transplantation or targeted pre - and probiotics.»
Dr Luis Pedro Coelho, commented: «These findings suggest that dogs could be a better model for nutrition studies than pigs or mice and we could potentially use data
from dogs to study the impact of diet on
gut microbiota in humans, and humans could be a good model to study the nutrition of dogs.
Exposure to lead during early development can alter the the
gut microbiota, increasing the chances for obesity in adulthood, researchers
from the University of Michigan School of Public Health have found.
Moeller is beginning to assemble a snapshot of the microbes in the
guts of our ancient ape ancestor — in essence, a paleo
gut that fit our paleo diet — and hopes to go even further back in time if, as seems likely, all mammals have evolved their unique
microbiota from a common ancestral population in the distant past.
In addition, cohousing coprophagic mice harboring transplanted
microbiota from discordant pairs provides an opportunity to determine which bacterial taxa invade the
gut communities of cage mates, how invasion correlates with host phenotypes, and how invasion and microbial niche are affected by human diets.
Research
from McMaster University has found that bacteria in the
gut impacts both intestinal and behavioural symptoms in patients suffering
from irritable bowel syndrome (IBS), a finding which could lead to new
microbiota - directed treatments.
The goal of the study was to explore whether fecal
microbiota from human IBS patients with diarrhea has the ability to influence
gut and brain function in recipient mice.
Interestingly, the authors noted that since the study showed that
microbiota in the
gut can influence the brain, it «adds to evidence suggesting that the intestinal
microbiota may play some role in the spectrum of brain disorders ranging
from mood or anxiety to other problems that may include autism, Parkinson's disease and multiple sclerosis.»
«The results help to support the assumption that the
gut microbiota is not — as previously thought — stable
from the moment a child is a year old.
«Up until now, it was impossible to study the impact of probiotics on
gut microbiota at a bacterial species level;
from now on we will have a much more detailed view of the dynamics of this ecosystem» says Dusko Ehrlich.
The investigators found that despite their diet, these giant pandas, together with nine captive and seven wild individuals investigated previously, showed extremely low
gut microbiota diversity and an overall structure that diverged
from non-panda plant - eaters but was similar to carnivorous and omnivorous bears.
«The results
from the study can be used to support initiatives that can be used to help children develop a type of
gut microbiota, which is beneficial for the immune system and for the digestive system.
Scientists
from INRA and Danone Nutricia Research have shown the effect of a fermented milk product containing probiotics on the
gut microbiota, using a novel high resolution bioinformatics tool.
Panda
gut microbiota also varied by season, with late autumn being quite different
from spring and summer.
«In general, it seems that the
gut microbiota recovery
from antibiotic treatment lasts more than a year.
«We showed that the presence of the maternal
gut microbiota during late pregnancy blocked the passage of labeled antibodies
from the circulation into the brain parenchyma of the growing fetus,» says first author Dr. Viorica Braniste at the Department of Microbiology, Tumor and Cell Biology at Karolinska Institutet.
Gut microbiota that live in the outer regions of the mucus and remain a safe distance
from epithelial cells provide a benefit to the host, but Chassaing and Gewirtz hypothesize that
microbiota that encroach upon host cells drive chronic inflammation that interferes with the normal action of insulin, promoting type 2 diabetes.
In one of the largest longitudinal studies of the microbiome to date, researchers
from the Broad Institute of MIT and Harvard, Massachusetts General Hospital (MGH), and the DIABIMMUNE Study Group have identified a connection between changes in
gut microbiota and the onset of type 1 diabetes (T1D).
To define a relationship between
gut bacteria and the efficacy of ACT, the researchers transplanted fecal
microbiota from Jackson mice to Harlan mice.
These include lipid lowering; protection
from oxidative stress and inflammation; modification of growth factors that can promote cancer; inhibition of nutrient sensing pathways by amino acid restriction and
gut microbiota - mediated production of metabolites.
We are using the most powerful and advanced techniques including metabolomics, transcriptomics, genomics and the analysis of the
gut microbiota to understand what effect, the Mediterranean style diet has on the population of over 65 years old» said prof. Claudio Franceschi, project coordinator
from the University of Bologna, Italy.
Clostridium difficile - associated disease (CDAD) is the major known cause of antibiotic - induced diarrhea and colitis, and the disease is thought to result
from persistent disruption of commensal
gut microbiota.
These steps are intended to crack open the biological material in the sample:
from the comparatively massive eukaryotic cells of bat tissue, to simpler
gut microbiota, to tiny viral particles.
The researchers trapped more than 800 wild mice
from eight locations across Maryland and the District of Columbia to find healthy, suitable candidates for a
gut microbiota donation.
Interactions of Dihydromyricetin, a Flavonoid
from Vine Tea (Ampelopsis grossedentata) with
Gut Microbiota — Li Fan — Journal of Food Science
Review: New Therapeutic Drugs
from Bioactive Natural Molecules: the Role of
Gut Microbiota Metabolism in Neurodegenerative Diseases — Francesco Di Meo — Current Drug Metabolism
OBJECTIVES We aimed at evaluating the composition of the
gut microbiota in adult patients with T1DM and T2DM and establishing a link between data obtained
from microbiological testing and the patients» clinical data.
A snapshot of
gut microbiota of an adult urban population
from Western region of India — Disha Tandon — PLOS One
«Collinsella provencensis» sp. nov., «Parabacteroides bouchesdurhonensis» sp. nov., and «Sutterella seckii» sp. nov., three new bacterial species identified
from human
gut microbiota — Niokhor Dione — New Microbes and New Infections
A few interesting articles in early life human microbiome, plus: A comparison between Staphylococcus epidermidis commensal and pathogenic lineages
from the skin of healthy individuals living in North American and India; A new tool to reconstruct microbial genome - scale metabolic models (GSMMs)
from their genome sequence; The seasonal changes in Amazon rainforest soil microbiome are associated with changes in the canopy; A specific class of chemicals secreted by birds modulates their feather microbiome; chronic stress alters
gut microbiota and triggers a specific immune response in a mouse model of colitis; and evidence that the short chain fatty acids profile in the
gut reflects the impact of dietary fibre on the microbiome using the PolyFermS continuous intestinal fermentation model.
They decided to explore whether AIM2's protective role might involve
gut bacteria, based on studies
from Kanneganti's lab and others indicating that microbial sensors similar to AIM2 contributed to healthy
gut microbiota.
Millions of measurements
from 23 people who consumed extra calories every day for a month reveal changes in proteins, metabolites, and
gut microbiota that accompany shifts in body mass.
Some questions we're all still trying to answer include the composition of the
gut microbiota, its effects on the permeability of the lining of the gastrointestinal tract, its effects on whole - body inflammation, and its effects on neuronal signaling
from the
gut to the brain.
Rawls, J. F., Mahowald, M. A., Ley, R. E. & Gordon, J. I. Reciprocal
gut microbiota transplants
from zebrafish and mice to germ - free recipients reveal host habitat selection.
Other studies have looked at the
gut microbiota (ie, the bacteria in our stool) in people with different diets and have found that the microbiome in those who eat meat differs
from vegetarians, and further differs
from that in vegans.
One of the most interesting answers to be had to that question, as it relates specifically to the
microbiota, comes
from a research paper published in The Journal of
Gut in 2014, and this study wanted to look at what does the microbiota, again the microbiota being the world of bacteria that live in your gut, what is the difference between an elite rugby player compared to just a regular average J
Gut in 2014, and this study wanted to look at what does the
microbiota, again the
microbiota being the world of bacteria that live in your
gut, what is the difference between an elite rugby player compared to just a regular average J
gut, what is the difference between an elite rugby player compared to just a regular average Joe.
«Your diet directly influences your
microbiota, and
from there it may influence the status of your
gut's mucus layer and tendency toward disease.
Quantitative Imaging of
Gut Microbiota Spatial Organization, Oct. 2015 — Sonnenburg published findings, elimination of microbiota - accessible carbohydrates (MACs) from the diet results in thinner mucus, increased proximity of microbes to the epithelium, and heightened expression of inflammator
Microbiota Spatial Organization, Oct. 2015 — Sonnenburg published findings, elimination of
microbiota - accessible carbohydrates (MACs) from the diet results in thinner mucus, increased proximity of microbes to the epithelium, and heightened expression of inflammator
microbiota - accessible carbohydrates (MACs)
from the diet results in thinner mucus, increased proximity of microbes to the epithelium, and heightened expression of inflammatory markers.
This product
from Klaire Labs combines two prebiotics for a synergistic effect on
gut microbiota.
There are two ways to strengthen the
gut microbiota, and to allow its various populations to grow, to take probiotics orally, (
from functional fermented foods, or
from supplements), or to feed them with nutrients that stimulates their activity and multiplication.
GM [
gut microbiota] pattern in healthy infants differed dramatically
from that of the epileptic group.
Gut microbiota structure in epileptic infants (P1 group) differed dramatically
from that in the healthy infants (healthy group).
From birth, a healthy
gut microbiota is essential for the normal development of the gastrointestinal and immune systems.
The delicate balance between the human microbiome and the development of psychopathologies is particularly interesting given the ease with which the microbiome can be altered by external factors, such as diet, 23 exposure to antimicrobials24, 25 or disrupted sleep patterns.26 For example, a link between antibiotic exposure and altered brain function is well evidenced by the psychiatric side - effects of antibiotics, which range
from anxiety and panic to major depression, psychosis and delirium.1 A recent large population study reported that treatment with a single antibiotic course was associated with an increased risk for depression and anxiety, rising with multiple exposures.27 Bercik et al. 28 showed that oral administration of non-absorbable antimicrobials transiently altered the composition of the
gut microbiota in adult mice and increased exploratory behaviour and hippocampal expression of brain - derived neurotrophic factor (BDNF), while intraperitoneal administration had no effect on behaviour.