Luc Douay at Pierre and Marie Curie University, Paris, and his colleagues extracted what are called
haematopoietic stem cells from a volunteer's bone marrow.
Recently, working with many colleagues, the Penn team published in Nature the first application of 2PLM to directly quantify the physiological environment of blood stem cells,
called haematopoietic stem cells, or HSCs.
Mossadegh - Keller N, Sarrazin S, Kandalla PK, Espinosa L, Stanley RE, Nutt SL, Moore J, Sieweke MH M - CSF instructs myeloid lineage fate in
single haematopoietic stem cells.
Is it feasible to conduct a randomised controlled trial of pretransplant exercise (prehabilitation) for patients with multiple myeloma awaiting
autologous haematopoietic stem cell transplantation?
This study provides an experimental system to further understand how benzene metabolites impair the regulation
of haematopoietic stem cells, the researchers say.
The team studied the effects of 1,4 - BQ on «
haematopoietic stem cells» (HSCs are stem cells found in the bone marrow that can give rise to any kind of blood cell) and «haematopoietic progenitor cells» (each HPC in the bone marrow can differentiate into only one specific type of blood cell) in mice.
Haematopoietic stem cells are found in the bone marrow and give rise to all the blood cell types.
The team's next step will be to image oxygen along with other metabolites and simultaneously visualize
the haematopoietic stem cells themselves as they inhabit the niche.