For questions regarding breed survey, hip and elbow dysplasia, tattooing, tooth certificates or
haemophilia see the Breed Matters Section: Breed Survey, Hip & Elbow Dysplasia, Tattoo, Tooth Certificates, Haemophilia
Not exact matches
Kanjaksha Ghosh has
seen more than a thousand people with
haemophilia since he became a physician.
When he delved into the genomes of those with a milder disease, he often
saw not just a mutation in the affected clotting - factor gene, but also a mutation in another gene — the first causing
haemophilia, the tendency to bleed, and the second causing thrombophilia, the tendency to clot.
Roughly 5 % of those with
haemophilia B fall into this category, and 30 % of those with
haemophilia A (
see page S12).
When treated with replacement coagulation proteins, the dog naturally develops antibodies, or inhibitors, against the therapy — a problem that is also
seen in some 5 % of humans with
haemophilia B.
Shire CEO Flemming Ornskov - who has a large conventional
haemophilia business and is also chasing Biomarin and Spark in hunting a cure for the bleeding disorder -
sees both the opportunities and the difficulties of gene therapy.
2011 Six people with clotting disorder
haemophilia B
see a reduction in symptoms after gene therapy on liver cells.
As these therapies emerge, dealing with
haemophilia will become less troublesome (
see below).
Spark Therapeutics» gene therapy for patients with
haemophilia has
seen some early success in clinical trials, after being tested in 10 male patients
Spark Therapeutics» gene therapy for patients with
haemophilia has
seen some early success in clinical trials, according to a report published yesterday.