«Adrenal steroid hormone concentrations in dogs with
hair cycle arrest (Alopecia X) before and during treatment with melatonin and mitotane.»
During postnatal growth of the skin and
homeostatic hair cycling, different proliferative compartments contribute to tissue expansion and establishment of a functional epidermis.
These hormones instruct the hair follicle to undergo changes to prepare for the
next hair cycle.
Alopecia X is a term given by many veterinary dermatology professionals to describe a «
hair cycle abnormality» which is known to affect predominantly Nordic breeds, Pomeranians, Toy and Miniature Poodles.
It is also called «Post-clipping Alopecia» «Growth Hormone Responsive Alopecia», «Adult Onset Growth Hormone Deficiency», «Castration Responsive Alopecia», «Adrenal Sex Hormone Alopecia» «
Hair Cycle Arrest» and «Adrenal Hyperplasia - Like Syndrome».
The hair cycle is kept stagnant due to which we have more hair on our head.
Normally,
your hair cycle goes through the phases of growth and loss.
Once pregnant, the process
your hair cycles through is slowed down.
It can last a few weeks or a few months, depending on how long
your hair cycles last.
«We need to establish the origins of the critical intrinsic properties of the newly induced hairs, such as
their hair cycle kinetics, color, angle, positioning, and texture» said Dr. Jahoda.
In the absence of CerS4, the keratinocytes are hyperactive and migrate too much, thereby disrupting
the hair cycle.
The drugs, it turned out, had kick - started
their hair cycles, putting follicles into an active growth phase.
The acids also help in restoring the overall balance of
the hair cycle and minimize the chances of hair loss.
According to one doctor, Marc Glashofer, MD «When you have a really stressful event, it can shock
the hair cycle (pushing) more hair into the shedding phase.
The four main stages of
the hair cycle are: anagen (characterized by rapid growth and proliferation), catagen (a period of cell apoptosis), telogen (a resting period) and exogen (hair loss from the root)[9].
In some breeds the active or growing part of
the hair cycle is prolonged, as in Yorkshire terriers, like it is in people.
These breeds are more sensitive to drug therapy, like chemotherapy, that interfere with
the hair cycle, and they develop alopecia as an adverse effect.