Sentences with phrase «hair gene in»

The fact that adult Europeans are twice as likely as Asians to tolerate lactose in milk (no location yet) reflects a much longer history of dairy farming in the West; the ability to dehydrogenate alcohol (chromosome 4) is more common in people with a history of drinking fermented fluids; the prevalence of the blond - hair gene in young northern Europeans (perhaps on chromosome 15?)

Not exact matches

Birds, for example, can regenerate hair cells — and lately researchers have found a few similar effects in mammals that used gene and drug therapy.

Scientists have figured out the specific gene mutation responsible for red hair — and why it's more common in beards than on heads.

While we both made use of the dominant gene for hair and eye pigment, in us somewhere was the recessive genes for blonde and blue.

In reality, the amount of hair depends on the genes your baby inherits.

Other factors such as hormones and genes also cause hair loss, but the key factor is the deficiency in nutrients.

Another reason why a baby might have Heterochromia iridium or Heterochromia iridis is Waardenburg syndrome in which a gene mutation occurs, causing changes in the pigmentation levels of the hair, iris and skin.

Genetic variations most strongly associated with high scores were found near the GATA2 gene — involved in the development of inner ear hair cells and the inferior colliculus.

Another gene, PCDH15, plays a role in the hair cells» ability to convert sound into brain signals (Molecular Psychiatry, DOI: 10.1038 / MP.2014.8).

Now David He at Creighton University in Omaha, Nebraska, and colleagues have shown that the same gene can repair guinea pigs» existing, damaged hair cells — as long as you get to them in time.

So far, gene therapy attempts have only resulted in partial improvements of hearing in mouse models of specific human deafness forms that did not include severe anomalies in hair cell structure.

With a single local injection of the USH1G gene just after birth, the scientists observed a restoration of the structure and mechanosensory function of the inner ear hair bundles — profoundly damaged before birth -, resulting in a long - term partial recovery of hearing, and complete recovery of vestibular function in these mice.

The researchers traced the white pattern to just two small changes in a gene associated with hair color.

The team now plans to improve their gene - delivery technique in an attempt to reach an even greater proportion of hair cells.

Since patients (and mice) with Usher 1c also have balance problems caused by hair - cell damage in the vestibular organs, the researchers also tested whether gene therapy restored balance.

The participants» diverse backgrounds, which included African, European, and Native American ancestry, helped reveal relationships between genes and hair that would have been hidden in more homogeneous populations.

The gene variant linked to graying is found only in people with European ancestry, and it has previously been associated with light hair colors.

Now, in a study that looked at the genomes of more than 6000 people from Latin America, researchers have identified 18 genes that appear to influence hair traits, including the first ever to be associated with graying.

One clinical trial involves the drug CGF166, a one - time gene therapy, which, if proven successful in humans, could regenerate new hair cells within the cochlea that can signal the part of the brain that processes sound.

The gene IRF4 helps regulate melanin in the body, which determines - among other things - hair color.

«Switching off a gene is of course feasible, the issue is whether it will have the desired effect and whether it's the right thing to do... But in terms of trying to develop a therapy to delay or prevent hair graying, that is something that is potentially feasible; yes.»

Sensory hair cells in the cochlea of a Beethoven mouse treated with TMC2 gene therapy.

This information could help researchers develop ways to restore the expression of more genes involved in hair growth and to increase the efficiency of the induction.

In addition, using methods for the analysis of regulatory networks developed by the Califano lab in the Center for Computational Biology and Bioinformatics, Department of Systems Biology, the researchers identified a number of transcription factors (gene regulators) that have the potential to mimic the environmental signals that trigger papillae to induce new hair growtIn addition, using methods for the analysis of regulatory networks developed by the Califano lab in the Center for Computational Biology and Bioinformatics, Department of Systems Biology, the researchers identified a number of transcription factors (gene regulators) that have the potential to mimic the environmental signals that trigger papillae to induce new hair growtin the Center for Computational Biology and Bioinformatics, Department of Systems Biology, the researchers identified a number of transcription factors (gene regulators) that have the potential to mimic the environmental signals that trigger papillae to induce new hair growth.

In the early 2000s, cell biologists linked cyst formation to gene mutations that affect the primary cilia, hair - like projections from cells that seem to act as sensory antennae.

More than a hundred sites in the genome showed strong evidence of recent selection, including genes that affect muscle tissue, hair, hearing, immune - system function, skin pigmentation, sense of smell, and the body's response to heat stress.

In the recessive deafness model, gene therapy with TMC1 restored the ability of sensory hair cells to respond to sound — producing a measurable electrical current — and also restored activity in the auditory portion of the brainsteIn the recessive deafness model, gene therapy with TMC1 restored the ability of sensory hair cells to respond to sound — producing a measurable electrical current — and also restored activity in the auditory portion of the brainstein the auditory portion of the brainstem.

A team of scientists, led by academics from King's College London and Erasmus MC University Medical Center Rotterdam, have discovered 124 genes that play a major role in determining human hair colour variation.

The researchers found that the blond hair commonly seen in Northern Europeans is caused by a single change in the DNA that regulates the expression of a gene that encodes a protein called KITLG, also known as stem cell factor.

Researchers from the Eaton - Peabody Laboratories of the Massachusetts Eye and Ear and Harvard Medical School have created a new mouse model in which by expressing a gene in the inner ear hair cells — the sensory cells that detect sound and sense balance — protects the mice from age - related hearing loss (ARHL) and noise - induced hearing loss (NIHL), the two most common forms of deafness.

To deliver the healthy gene, the team inserted it into an engineered virus called adeno - associated virus 1, or AAV1, together with a promoter — a genetic sequence that turns the gene on only in certain sensory cells of the inner ear known as hair cells.

Christiano's lab uses specially bred mice to pinpoint genes involved in hair loss.

In addition, she and her colleagues think that they will be able to identify other genes that have an important role in hair cell functioIn addition, she and her colleagues think that they will be able to identify other genes that have an important role in hair cell functioin hair cell function.

Joint lead author Professor Manfred Kayser from Erasmus MC said: «Besides substantially increasing our understanding of human pigmentation genetics in general, finding these new hair colour genes is also important for further increasing the accuracy of hair colour prediction from DNA traces in future forensic applications, which can help to find unknown perpetrators of crime.»

In order to identify the previously unknown hair colour genes, researchers analysed DNA data from almost 300,000 people of European descent, together with their self - reported hair colour information.

Still, by identifying the human hairless gene as an important master switch in regulating cell death in a hair follicle — a discovery that could lead to gene therapies for unwanted hair growth — Christiano emerged as a new star in the field, and a glamorous one.

We found that women have significantly fairer hair than men, which reflects how important cultural practices and sexual preferences are in shaping our genes and biology.»

«Scientists identify proteins crucial to loss of hearing: Proteins play key role in genes that help auditory hair cells grow.»

«To our knowledge, our model is the first in which expression of a single gene in postnatal hair cells results in hair cell survival and hearing preservation in mice that otherwise suffer from age - related and noise - induced hearing loss,» Dr. Chen said.

They then used next generation sequencing — a state - of - the - art method to rapidly measure gene expression — to sequence and quantify the thousands of genes that are expressed in hair cells, in comparison with other cells in the ear.

Based on the CT based anatomical observations in probainognathians, it appears that the MSX2 gene underwent a significant change in its expression 240 - 246 million years ago and triggered the evolution of many typical mammalian traits including hair and whiskers, an enlarged cerebellum, complete ossification of the skull roof, and more importantly, the mammary glands, that define mammals today.

A possible fix arose in 2003, when researchers discovered that certain genes can transform the cells supporting the hair cells into both types of hair cell.

The full readout of what genes are on and off in dermal papilla cells has never been collected before, so researchers now have a new list of thousands of genes to study further that may play key roles in hair follicle development.

In its normal form, the gene produces a hormone that inhibits eating and also influences hair pigmentation.

In cells grown on flat culture dishes, the expression of thousands of genes didn't match up with their normal patterns, explaining why the cells from those dishes had been unable to generate new hair follicles.

New research suggests that fluid driven by tiny swirling hairs called cilia may activate certain genes in the growing embryo that lay the groundwork for this asymmetry.

After his team first observed hair loss in Treg - deficient mice, Rosenblum learned that the genes associated with alopecia in previous studies are almost all related to Tregs, and treatments that boost Treg function have been shown to be an effective treatment for the disease.

David Reed of the University of Florida in Gainesville, Florida, US and collaborators then analysed the DNA of these parasites and compared the gene mutations with those seen in the Pthirus pubis lice, which can live in the pubic hairs of modern - day humans.

The Swiss researchers have demonstrated that, when EDA is malfunctioning in lizards, they fail to develop a proper scale placode, exactly as mammals or birds affected with similar mutations in that same gene can not develop proper hairs or feathers placodes.

«We identified that the peculiar look of these naked lizards is due to the disruption of the ectodysplasin - A (EDA), a gene whose mutations in humans and mice are known to generate substantial abnormalities in the development of teeth, glands, nails and hairs», says Michel Milinkovitch.