Sentences with phrase «half of advanced melanomas»
Approximately 50 percent of advanced melanoma tumors are driven to grow by the presence of BRAF mutations and another 20 percent by the presence of NRAS mutations.
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«It was approved in 2011 for first - line treatment of advanced melanoma in the US and Europe.
According to Herlyn, these slow - growing JARID1B cells represent only one to five percent of the cells in a tumor, yet readily divide into the fast - growing cells that are the hallmark of advanced melanoma.
They say their findings, being presented June 2 at the 50th annual meeting of the American Society of Clinical Oncology (ASCO), offered several clinical insights that could lead to different treatment strategies and perhaps influence staging of advanced melanoma.
Importantly, mutations in the BRAF gene that are seen in more than half of advanced melanomas were absent in mucosal melanoma, explaining the ineffectiveness of BRAF - targeted treatments like vemurafenib.
«Metastatic brain tumors — often from lung, breast or skin cancers — are the most commonly observed tumors within the brain and account for about 40 percent of advanced melanoma metastases.
On October 27, 2015, the FDA approved a new type of immunotherapy for the treatment of advanced melanoma.
About half of all advanced melanomas have a mutation in a gene called BRAF which drives the proliferation of the cancer.
Nivolumab is already FDA - approved for the treatment of advanced melanoma — news that came just recently in December 2014.
The FDA approved it last year for the treatment of advanced melanoma, and we think it can help overcome the resistance that we've seen to pembrolizumab.
T - VEC, recently approved for the treatment of advanced melanoma, is an oncolytic herpes simplex virus type 1 engineered to replicate selectively in tumor cells and express human granulocyte - macrophage colony - stimulating factor.
Not exact matches
Pairing the BRAF inhibitor with the MEK inhibitor has given patients with advanced melanoma one of their best treatment options to date.
But we still have a long way to go before we will have affordable therapies able to prolong survival from advanced melanoma by several years with a decent quality of life.»
«As well as finding more effective treatments for advanced melanoma, we also need to stress the importance of early diagnosis, detecting tumors before they have a chance to spread.»
Treatment for advanced melanoma has seen success with targeted therapies — drugs that interfere with division and growth of cancer cells by targeting key molecules — especially when multiple drugs are used in combination.
While one drug, MEK inhibitor, is usually used in advanced - stage melanoma, the other drug, CDK4 / 6 inhibitor, palbociclib, is currently FDA - approved for treatment of Estrogen Receptor - positive breast cancer patients.
«Dr. Aplin's major research advance is part of a larger effort by the Sidney Kimmel Cancer Center to develop new strategies for treating melanoma.
In my experience, this marks both the first clinical trial of an approved drug with an effect on survival in advanced melanoma in the adjuvant setting, and, in this same setting, the first to study an immune checkpoint inhibitor in the adjuvant setting.
When 45 cancer patients, most with advanced melanoma, took a cocktail of the BRAF and MEK inhibitors, there were few significant side effects.
In the April 25 issue of Cancer Cell, a research team, led by Xin Lu, PhD, Ludwig director and member at the University of Oxford and a team of scientists from both institutions, describes how p53 is silenced in advanced melanomas by a protein named iASPP, and applies that information to restore p53 function in such cells.
Though uveal melanoma is rare — there are only 2,500 cases diagnosed in the United States each year — about half of patients will develop metastatic disease, and survival for patients with advanced disease has held steady at nine months to a year for decades.
Trial # 2: Phase I trial of HCQ with dose - intense temozolomide in patients with advanced solid tumors and melanoma
«But this opens the possibility of improving clinical outcomes and decreasing serious side effects in treating advanced melanoma with ipilimumab.»
The first such drug, called ipilimumab (Yervoy), developed out of Allison's basic science research, showed much lower response rates against advanced melanoma than those obtained with targeted drugs, but long - term follow - up found that 22 percent of those treated with Yervoy survived at least four years, unprecedented results for the disease.
Reporting the results from three trials of pembrolizumab for patients with advanced melanoma, Dr Marcus Butler, a medical oncologist at the Princess Margaret Cancer Centre, Toronto, Canada, told ECCO2017 that 84 of the 1567 patients in the KEYNOTE - 001, 002 and 006 studies had advanced mucosal melanoma.
«We have found that the individual cells within melanoma tumors are not all identical, and tumors contain a sub-population of cells that are inherently drug resistant, which accounts for the fact that advanced melanoma tumors return no matter how much the tumor is depleted,» said Meenhard Herlyn, D.V.M., D.Sc., professor and director of Wistar's Melanoma Researchmelanoma tumors are not all identical, and tumors contain a sub-population of cells that are inherently drug resistant, which accounts for the fact that advanced melanoma tumors return no matter how much the tumor is depleted,» said Meenhard Herlyn, D.V.M., D.Sc., professor and director of Wistar's Melanoma Researchmelanoma tumors return no matter how much the tumor is depleted,» said Meenhard Herlyn, D.V.M., D.Sc., professor and director of Wistar's Melanoma ResearchMelanoma Research Center.
The first of these drugs, ipilimumab (Yervoy ®) was approved by federal regulators to treat advanced melanoma.
The group plans to continue exploring the mechanics of SF3B1 while also pushing forward with the preclinical work needed to form the rational basis for targeting this gene in patients with advanced mucosal melanoma.
«FDA approval of revolutionary two - drug combo to treat advanced melanoma.»
The agency interrupted a Phase III trial of 675 patients with advanced melanoma to approve the drug when it became clear it was extending survival.
«Having a potential new way to keep melanoma at bay is a major advance for patients who live under the constant fear of recurrence after surgery.
New research on innovative immunotherapies for advanced or high - risk melanoma and cervical cancer were presented today at the 50th Annual Meeting of the American Society of Clinical Oncology (ASCO).
The new studies find high activity with investigative drugs for advanced melanoma, and show for the first time that ipilimumab, a treatment already approved for advanced melanoma, can substantially decrease the risk of melanoma recurrence in certain patients with earlier - stage disease.
Moffitt Cancer Center researchers participated in an international phase 3 study that demonstrated that a drug called ipilimumab improves the relapse - free survival of advanced stage melanoma patients rendered free of disease surgically but at high risk for relapse.
Dr Larkin said: «Results from our large analysis of pre-defined sub-groups of patients with advanced melanoma provide evidence that suggests the combination of the two drugs consistently improves progression - free survival across a range of sub-groups, including patients with poor prognostic factors, when compared with either nivolumab or ipilimumab alone.»
Researchers wanted to determine if ipilimumab could improve the survival of advanced - stage melanoma patients if it was given after the surgical removal of both their primary melanoma tumors and their regional lymph nodes.
They found that injecting patient - derived, brain - seeking melanoma cells into the carotid artery of these preclinical models resulted in the formation of many metastatic tumors throughout the brain, mimicking what is seen in advanced melanoma cancer patients.
In late 2015, the FDA approved a first - of - its - kind treatment for patients with advanced melanoma: an engineered herpes virus.
An anti-PD-1 antibody developed by Bristol - Myers Squibb generates excitement with results from a phase I trial showing that, among 236 patients with various types of cancer, the treatment shrank tumors in 28 percent of melanoma patients, 30 percent of patients with kidney cancer, and 18 percent of patients with advanced non-small cell lung cancer.
Adoptive T cell transfer plus dendritic cell vaccination: Patients with advanced stage of melanoma (NCT00338377)
A Phase I / II, Open - label, Multi-center Study of the Safety and Efficacy of IMCgp100 using the Intra-patient Escalation Dosing Regimen in Patients with Advanced Uveal Melanoma
Researchers have identified characteristics associated with improved outcomes when treating BRAF - mutated advanced melanoma with the combination of dabrafenib and trametinib.
A Phase I / II Study of Pembrolizumab (MK - 3475) in Children with Advanced Melanoma or a PD - L1 Positive Advanced, Relapsed or Refractory Solid Tumor or Lymphoma
Patients with advanced or metastatic melanoma have been able to live longer cancer - free lives because of several new therapies approved over the last decade, such as BRAF and MEK inhibitors.
«This study, designed to determine if CTCs are associated with relapse, detected CTCs in approximately 40 % of advanced - stage melanoma patients.»
Do date surgery is considered the most definitive treatment for early - stage melanoma, but it is rarely curative for the advanced stages of melanomas [8].
Dr. Turaga has significant experience in the management of melanoma, and complex sarcomas and has pioneered the approaches of isolated limb infusion for advanced malignancies for limb preservation so as to avoid amputation.
While an earlier study had shown a similar immunotherapy drug to be effective for a significant proportion of patients with advanced melanoma or lung or kidney cancer, checkpoint inhibitors weren't making headway with colon cancer.
One of the most prominent patients is former president Jimmy Carter, who last year was diagnosed with advanced melanoma that had spread to his brain.
Ronai is being recognized for his significant contributions to melanoma research that are advancing understanding of this deadly form of skin cancer and could lead to new treatments.