Sentences with phrase «hallmark of cancer»

The effects of mutations and other genetic changes in cancer cells play out in the complex networks of molecular interactions or «signaling pathways» involved in cell growth, proliferation, and other hallmarks of cancer biology.

This widespread lack of the need for telomerase is used by evolution as a key component of our defense against cancer, because having a limit to the size and renewal of telomeres prevents our cells from replicating themselves indefinitely — the crucial hallmark of cancer.

You can read the first seven Hallmarks of Cancer articles here.

Dot Bennett of St George's University of London and colleagues found that only four of 37 skin cancer samples they examined displayed the supposed hallmark of cancer.

However, a key hallmark of cancer progression entails invasion and metastasis [2].

Alterations in the acquisition and metabolism of nutrients are now firmly recognized as hallmarks of cancer development.

Acquired genomic structural variants (SVs) are major hallmarks of the cancer genome.

They also show how this interaction can increase proliferation, migration and invasion of tumor cells, three hallmarks of cancer growth and spread.

When these genes are silenced a barrier is removed that might otherwise stop the cells from growing uncontrollably — a hallmark of cancer.

When mutated, BRAF, an enzyme that acts in a signaling cascade known as the MAPK / ERK pathway, becomes overactive and leads to increased cellular growth, a hallmark of cancer.

One of the hallmarks of cancer cells is they don't experience apoptosis and keep dividing out of control.

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As a cancer drug, BEZ235 works by inhibiting the PI3K and mTOR metabolic pathways, which help fuel the unchecked cell division that is a hallmark of cancer.

She adds that the dawning realization that metabolic dysfunction may be a hallmark of cancer applies to solid tumors (like those in breast and lung cancer) as well as liquid tumors (like leukemia and lymphoma).

«Metastasis is a hallmark of cancer and a leading cause of cancer death,» says the study's senior author, Zhenkun Lou, Ph.D., of Mayo Clinic.

The Hallmarks of Cancer are ten underlying principles shared by all cancers.

By using hemoglobin as the contrast agent or indicator, photoacoustic imaging is highly sensitive to abnormal angiogenesis, the abnormal formation of new blood vessels, which is a hallmark of the cancer tumors.

Uncontrolled cell division in the body is a process by which tumours form and hence is a hallmark of cancer.

«We developed 3BrPA to target a hallmark of cancer cells, namely their increased dependency on glucose compared with normal cells.

This makes sense: By driving the proliferation of infected cells, viruses speed manufacture of more viruses, but excessive cellular proliferation is also a hallmark of cancer.

«This sort of genetic instability is a hallmark of cancer biology,» Jha said.

Uncontrolled cell division is a hallmark of cancer, and BMH - 21 has demonstrated an ability to bind to the DNA of cancer cells and completely shut down this transcription pathway.

By keeping telomeres long, ATRX mutations give cells the ability to endlessly divide, a hallmark of cancer.

Chemotherapy drugs tend to target rapidly dividing cells, because fast replication is a hallmark of cancer cells.

Failure of this regulation not only impairs the process of development, but also contributes to the reversal of cell differentiation and the uncontrolled cell growth that are the hallmarks of cancer.

Using genetic tools to establish in which cells cancer - driving mutations originated and then propagated into other cancer cells, they demonstrated that a distinct and rare subset of MDS cells showed all the hallmarks of cancer stem cells, and that no other malignant MDS cells were able to propagate the tumour.

A jump that disrupts a gene encoding a blood - clotting protein called factor VIII can cause the bleeding disorder hemophilia A. Production of one of LINE - 1's proteins called ORF1p is a hallmark of cancer, Burns and colleagues reported in 2014 in the American Journal of Pathology.

Sustained angiogenesis, the growth of new blood vessels, and the suppression of the immune system are hallmarks of cancer, with an increasing amount of evidence demonstrating that these two activities are interrelated.

Epigenetic changes are a hallmark of cancer, but up until now, it has not been known whether these changes on their own are sufficient to push healthy cells down the cancer path.

Most cancer drugs are designed to halt cell growth, the hallmark of cancer, and one popular target is the pathway that controls the production of a cell's thousands of proteins.

Fresh insights into how cells detect damage to their DNA — a hallmark of cancer — could help explain how the body keeps disease in check.

This is important because the programmed cell death process works to eliminate dysfunctional cells, and one of the hallmarks of cancer is the ability of malignant cells to evade this key natural process.

Both genes code for proteins that function as growth factor receptors, meaning they sit on the surface of cells and, when activated, can spur the rapid cell growth that is a hallmark of cancer.

Since proliferation is a hallmark of cancer cells, the researchers analyzed the involvement of tRNA halves in tumorigenesis.

However, when this process goes awry, cancers can arise: damaged DNA or the activation of particular genes known as «oncogenes» can trigger a cascade of activity that can lead ultimately to unchecked proliferation, the hallmark of a cancer.

Douglas Hanahan and Robert Weinberg publish an update of their seminal review, Hallmarks of Cancer, adding to the list of cancer characteristics the ability of tumors to evade the immune system and emphasizing immune system - induced inflammation as an enabling characteristic in cancer development.

Notably, the six hallmarks of cancer were further supported and refined, was was the enabling characteristic of genome instability.

In 2000, Hanahan and Weinberg published a landmark article in which they described the «hallmarks of cancer» — six biological capabilities acquired during the multi-step development of human tumors.

Renowned cancer researchers Robert Weinberg and Douglas Hanahan and have updated the «Hallmarks of Cancer», their seminal review that codified the traits that all cancers have in common.

After defending my dissertation in 2010, I began a postdoctoral project in the van Oudenaarden laboratory at MIT, aiming to understand the Warburg effect, a hallmark of cancer cells characterized by the fermentation of glucose in the presence of enough oxygen to support respiration.

One hallmark of cancer is the accelerated metabolism, high energy requirements, and increased glucose uptake by the tumor cells, the latter being the first and rate - limiting step for glucose metabolism [2,3].

A third type of immunotherapy aims to target mutated proteins that are a hallmark of cancer.

The study establishes a link between TDRD3 and an enzyme that unwinds DNA at regions of active gene expression, and provides evidence that this partnership can prevent DNA breakage and chromosomal translocations - two of the hallmarks of cancer.

Bypassing apoptosis is a hallmark of cancer, and medical science is eager to find new ways of «reprogramming» cancer cells to die.

Abnormal DNA methylation is a hallmark of cancer.

Refining Dynamic Risk Stratification and Prognostic Groups for Differentiated Thyroid Cancer With TERT Promoter Mutations JCEM February 28, 2017 Tae Hyuk Kim, Chang - Seok Ki, Hye Seung Kim, Kyunga Kim, Jun - Ho Choe, Jung - Han Kim, Jee Soo Kim, Young Lyun Oh, Soo Yeon Hahn, Jung Hee Shin, Hye Won Jang, Sun Wook Kim, and Jae Hoon Chung Telomere reverse transcription (TERT) activation, one of the hallmarks of cancer, enables unlimited proliferation and is driven by oncogenes...

The study provides evidence that this partnership can prevent DNA breakage and chromosomal translocations — two of the hallmarks of cancer.