Sentences with phrase «hallmark of the disease»

The pathological hallmark of this disease is the accumulation of alpha - synuclein, which in turn leads to cell death and consequently to problems in neurotransmission.

And while some, including a 2013 study in the journal The Lancet and a 2015 paper in the journal Nature, have yielded some promising clues, none have been able to spot any precise, reliable genetic hallmarks of the disease.

This aberrant brain circuitry — the amyloid plaques and tau tangles — became the twin hallmarks of the disease that bears his name.

Upon her death he examined her brain tissue and found the distinctive lesions that are now hallmarks of the disease.

«One of the things we know about Alzheimer's disease is that this region of the brain is one of the very first to exhibit a key hallmark of the disease, deposition of neurofibrillary tangles.»

Researchers found hallmarks of the disease among 99.5 percent of the subjects they examined in Mexico City.

Trotman and his team, which included collaborators from Weill Cornell Medical College, Mt. Sinai School of Medicine and the Dana - Farber Cancer Institute, used RapidCaP to generate mice that developed metastatic prostate cancer with classic hallmarks of this disease, including resistance to hormone therapy.

The gene is also linked to formation of the amyloid - beta peptide associated with sticky plaque, one of the supposed hallmarks of the disease, but how ApoE4 actually brings or heightens risk for the disease is unclear.

The biochemical hallmark of the disease in affected dogs is the accumulation of the L -2-hydroxyglutaric acid (L -2-HGA) in cerebrospinal fluid, plasma and urine [1].

Together, these plaques and neurofibrillary tangles form the pathological hallmarks of the disease.

An estimated 40 percent of the population has the primary gene variant associated with celiac disease, but only 1 percent of people with these genes go on to develop intestinal inflammation and damage — the hallmarks of the disease — after ingesting gluten.

In the first method, doctors inject a radioactive dye that binds to amyloid plaque, a damaging protein that accumulates in patients» brains and is the hallmark of the disease; then they detect the dye with a pet scan of the brain.

Ozanimod significantly slowed the loss of brain volume compared with IFN — a hallmark of the disease that causes brain atrophy, disease progression and cognitive impairment.

The treatment, which delayed the neural degeneration that is the hallmark of the disease, appears to have overcome one of the problems that has dogged most other forms of gene therapy: the difficulty of getting «healthy» genes into enough cells in the body to produce therapeutic results.

If we could peer into the brains of these patients, we'd see two hallmarks of the disease.

The difficulty in delivering the oxygen necessary for neuronal activity may help explain the cognitive difficulties that are one of the hallmarks of the disease.

In examining autopsy samples from MS patients, the researchers detected an abundance of amyloids in brain lesions and damaged neurons, the hallmarks of the disease.

The sickling of red blood cells is the hallmark of this disease.

Although the cause of PD is unknown, damage to dopamine - producing neurons eventually leads to the movement disorders that are a hallmark of the disease.

In Alzheimer's disease, beta - amyloid proteins clump together to form amyloid plaques, a hallmark of the disease.

Amyloid plaques, a hallmark of diseases like Alzheimer's, may have catalysed life's metabolic reactions billions of years ago, long before enzymes appeared

But while sickle - shaped cells are the hallmark of the disease, they're not the only type of red blood cell present in people with the condition.

A hallmark of the disease is the accumulation of collagen in large nodules under the skin.

The researchers found that reports of shorter sleep duration and poorer sleep quality were associated with a greater β - Amyloid burden, a hallmark of the disease.

Fibrosis, or scarring, is a hallmark of the disease, and progressive tightening of the skin and lungs can lead to serious organ damage and, in some cases, death.

An estimated 40 percent of the population has the gene variants associated with celiac disease, but only 1 percent of people with these genes go on to develop intestinal inflammation and damage — the hallmarks of the disease — after ingesting gluten.

he body responds to tuberculosis infection by locking the bacterial offenders into tiny clusters of immune cells called granulomas, which are a hallmark of the disease.

The findings, presented Wednesday at the Alzheimer's Association International Conference in London, come from a four - year study launched in 2016 that is testing over 18,000 Medicare beneficiaries with mild cognitive impairment (MCI) or dementia to see if their brains contain the amyloid plaques that are one of the two hallmarks of the disease.

Plaques accumulate between neurons in the brains of Alzheimer's patients and are a hallmark of the disease.

Senior author Kenneth S. Kosik, co-director of UCSB's Neuroscience Research Institute, and Harriman Chair in Neuroscience, has been involved in the study of neurons that develop neurofibrillary tangles, one of the hallmarks of the disease, since he was a postdoctoral fellow.

This leads to progressive motor impairments that are a hallmark of the disease [3].

One approach is to attack amyloid, a hallmark of the disease.

But the hallmark of this disease is weight gain.

Because hormonal changes are the hallmark of this disease, almost every body system can be affected.

[3] Meanwhile, other research reveals cancer cells» high glucose consumption is a hallmark of the disease.

They also develop the hallmark of the disease «panleukopenia» (shortages of all types of white blood cells) because the parvovirus infection damages the bone marrow and lymph nodes.

These signs are hallmarks of both diseases and lead to the characteristic smell.

A hallmark of this disease is called shifting leg lameness, because different legs can be affected at different times.