The effects of mutations and other genetic changes in cancer cells play out in the complex networks of molecular interactions or «signaling pathways» involved in cell growth, proliferation, and other
hallmarks of cancer biology.
«This sort of genetic instability is
a hallmark of cancer biology,» Jha said.
Not exact matches
The study, «VlincRNAs controlled by retroviral elements are a
hallmark of pluripotency and
cancer» found that novel non-coding parts
of the human genome known as vlincRNAs (very long intergenic, non-coding RNAs) triggered by ancient viruses, participate in the
biology of stem cells, and in the development
of cancer.
The authors conclude that their six
hallmarks — sustained proliferative signaling, evading growth suppression, resisting cell death, replicative immortality, induction
of angiogenesis, and invasion / metastasis — continue to provide a useful conceptual framework for understanding the
biology of cancer.