Sentences with phrase «halt cell»

As a powerful tumor suppressor, p53 turns on genes that either halt cell division to allow time for repair of damaged DNA or, when all rescue attempts prove futile, to prevent cells with genetic defects from dividing, as this would fuel the development of cancer.

Dr. Tu's research focuses on the metabolic state of cells and responses to conditions that induce or halt cell division to promote survival and homeostasis.

In these mice, collagen made after an injury does not crosslink into a mass, so no scar tissue forms to halt cell migration and division.

In cultured cells, drugs that inhibit Cdk1 prevented HIF - 1alpha levels from falling and restored its ability to halt cell division, suggesting they may be effective treatments for certain cancers.

Meanwhile, other groups developed new ways of killing bacteria with vancomycin: One alteration found a novel way to halt cell wall construction, whereas another caused the outer wall membrane to leak, leading to cell death.

This indicated that loss of the gene might somehow be halting cell growth.

It is therefore essential that there be control mechanisms capable of detecting errors in this process and halting the cell cycle with the aim of allowing the cell to repair the breakages or, if not possible, to eliminate the damaged cell.

The treatment can also easily kill cancer cells, but in this experiment, it was vital to specifically show that it virtually halts cell migration.

Researchers know that p53 plays the crucial role of halting cell division when it detects that a cell's DNA has been damaged, as occurs in cancer or when a virus enters a cell.

«What's interesting is that even a single break transmits a global signal through the cell, halting cell division and growth,» says O'Shea.

Inhibiting RNR shuts down DNA synthesis and halts cell growth, making RNR inhibitors effective cancer drugs.

Researchers have found that indole -3-carbinol works by halting the cell cycle in breast cancer cells without actually killing the cells.

Not exact matches

Related Content Juno Halts Development of CAR T - Cell Cancer Immunotherapy Candidate JCAR015 Two More Deaths Reported in Juno Car - T Trial

Last month, it ordered Black Cell to halt its ICO and return all tokens to investors.

Case in point, the religious tries to halt stem cell research, which could mean that a cure for a disease that one of my kids develops might not be found.

Strawberries also contain fisetin, which halts the growth of cancerous cells while diminishing tumors» blood supply.

These antioxidants are partly responsible for halting DNA damage, which means cancerous cells can not mutate and form tumors.

As well as containing vitamins and minerals its abundant with polyphenol antioxidants which help protect against cancer, one polyphenol in particular can slow or halt the growth of cancer cells!

«Molecular Trojan horse delivers chemotherapeutic drug to cancer cells: Research offers valuable insights into halting metastasis.»

Both diseases result from the death of retinal cells, a process that Lanza suspects can be slowed or even halted using stem - cell - derived replacements.

They discovered that the chemicals and radiation used to kill tumor cells damage the stem cell reservoir in the hippocampus and nearly halt the formation of new neurons in both children and adults.

In these and other inherited diseases, 10 to 15 percent of the single - base pair mutations that cause the disease create a misplaced, premature «stop» codon in the middle of the gene — causing the machinery of the cell to prematurely halt synthesis of the protein, which destroys its ability to function.

These challenges were thrown into stark relief when Geron halted its stem - cell trial in November, having decided that the hurdles to commercializing the therapy were too great.

Our study points to potential therapeutic targets that could be inhibited to halt tumor cell movement,» says principal investigator Cynthia Reinhart - King, PhD.

Most cancer therapies are aimed at halting cancer growth by stopping cells from rapidly dividing.

Also known as the «Guardian of the Genome,» p53 fights cancer by causing damaged cells to die or by halting the growth of mutant cells before they become cancerous and spread to the rest of the body.

This brings the fatty acid cycle to a grinding halt, and the parasite can not divide for want of new cell membranes.

The importance of exosomes in the tumour microenvironment has been demonstrated within the field in recent years, as it has been shown that tumour development is halted if the production of exosomes inside the cancer cell is stopped.

Researchers at University of California San Diego School of Medicine report that a single infusion of wildtype hematopoietic stem and progenitor cells (HSPCs) into a mouse model of Friedreich's ataxia (FA) measurably halted cellular damage caused by the degenerative disease.

UT Southwestern Medical Center cancer researchers have identified a protein critical to the spread of deadly cancer cells and determined how it works, paving the way for potential use in diagnosis and eventually possible therapeutic drugs to halt or slow the spread of cancer.

Other evidence shows that miR - 7 can halt cancer cells that operate like stem cells, turning them into new kinds of tissue before they spread.

The transplanted cells would flourish into healthy blood cells, immune cells, or other elements the fetus lacked, the thinking went, thereby halting damage that a disease was already inflicting in the womb.

The embryos lacking functional BRCA2 genes probably stopped growing because molecular «checkpoints» in the developing embryo either halt the division of cells with damaged DNA, so that the damage can be repaired, or kill the cells outright.

Twelve people with Stargardt's macular dystrophy will be treated with retinal cells made from human embryonic stem cells (hESCs) in the hope of improving, or at least halting loss of sight.

«The goal is to halt the rate of photoreceptor loss,» says Robert Lanza, chief scientist at Advanced Cell Technology (ACT) of Worcester, Massachusetts, the company that has been developing the treatment since first turning hESCs into RPEs in 2004.

A Washington, D.C., judge said this afternoon that his ruling 2 weeks ago, halting all federal funding for human embryonic stem cell research, will stand while the case moves forward.

The protein, called STAT3, interferes with chemotherapy by halting the death of cancerous cells and allowing them to proliferate.

The T cell migration halted again when the team added a chemical that blocks the IGF - 1 receptor, the authors report 23 August in the Journal of Immunology.

Although the mix - up is being examined, the center has halted supplies of some of its iPS cells to researchers across Japan; the error also set back by a few years a CiRA project to produce clinical - grade platelets from iPS cells.

«Absence of a transcription factor halts tooth development in mid-stride: Without the transcription factor Sp7, two specialized types of cells that create dentin and enamel fail to mature.»

The treatment stopped the degeneration but the trial was halted in 2015 because genetic mutations were detected in another batch of iPS cells intended for another patient.

But then he observed the same halt in cell division in other cultures with different fetal tissues.

My European tour came to an abrupt halt when I accepted a position as marketing manager at Cell Media.

The suit to halt embryonic stem cell research was filed by James Sherley, Theresa Deisher, Nightlight Christian Adoptions, the Christian Medical Association, and others.

In experiments in mice and human cells, researchers found that blocking CXCR4 — a so - called homing receptor protein molecule that helps T cells mature and attracts blood cells to the bone marrow — halted disease progression in bone marrow and spleen tissue within two weeks.

They have identified a «checkpoint» manned by these immune cells that, if barred, can halt the development of the lung inflammation associated with allergies.

But the media hype is that somehow telomerase can increase our life span by circumventing the limit on cell replication and halting the aging process.

They showed in previous studies with cell cultures that when adding RK - 33 to malignant lung and other cancerous cells that highly express DDX3, proliferation slowed or halted, and the cells» ability to form colonies was impaired.

«We have found a way by which cytokinesis is temporarily halted and later started back up, and this phenomenon coordinates all cell players in the maturation of sperm cells in this niche,» says DiNardo.

He and colleagues figured that if the p53 protein was responsible for the positive switch, then blocking it in mice would halt the transition from scar - forming cells to blood vessel - forming cells.