Sentences with word «haploinsufficient»

Dissociation of frontotemporal dementia - related deficits and neuroinflammation in progranulin haploinsufficient mice.

In FTD, any benefit of exercise on progranulin levels would need to occur in haploinsufficient individuals and at older ages, so we considered it important to examine exercise in Grn + / − mice at a symptomatic age.

(11) To test for possible developmental compensation for more subtle Wnt defects, they examined haploinsufficient crosses of CAST / EiJ mTERT + / — mice; none of the multiple defects observed in mice with knockouts of multiple different Wnt subtypes; again, no such phenotypes were observed.