Sentences with phrase «haplotypes associated»

We also show that most autosomal haplotypes associated with domestication were already established in our Neolithic dogs, but that adaptation to a starch - rich diet likely occurred later.

MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels.

Not exact matches

Genome - wide association analysis comparing affected and unaffected PWC with the SOD1 mutation identified a haplotype within the gene «SP110 nuclear body protein'that was associated with increased risk of developing DM and early age of onset.

This requires the development of powerful bioinformatic approaches that allow prediction of haplotypes from numerous variants, and the classification of haplotypes into functionally related categories, in order to identify those specific sequence variants, or combinations of variants, associated with the disease phenotype.

«We also showed haplotype H was associated with a reduction in the number of copies of the mitochondrial DNA in cells, which might indicate that mitochondria in those cells are more efficient,» Professor Sherwin said.

Positively selected haplotypes of EGLN1 and PPARA were significantly associated with the decreased hemoglobin phenotype that is unique to this highland population.

A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus.

This analysis showed differential expression associated with the haplotypes at both loci, suggesting the risk haplotypes are associated with an effect on T - cell response.

Genetic variation at the eNOS locus is associated with diabetes, which may be attributable to an enhanced effect of total energy expenditure on glucose disposal in individuals with specific eNOS haplotypes.

Relative to the most common haplotype (111), two haplotypes (121 and 212) tended to increase diabetes risk (OR 1.22, 95 % CI 0.96 - 1.55), and one (122) was associated with decreased risk (0.58, 0.39 - 0.86).

The Y - chromosome haplotype reconstructed for CGG10023 was distinct from those Y - chromosome haplotypes present in the modern horses, supporting previous hypotheses that domestication was associated with a significant loss of Y - chromosomal diversity (12, 26).

We found that light skin associated variant of SLC24A5, shared by West Eurasians and South Asians occur on the same haplotype background.

Primary sclerosing cholangitis (PSC) is strongly associated with several human leukocyte antigen (HLA) haplotypes.

In the Springer spaniel, the DLA - DRB1 * 015:01 — DQA1 * 006:01 — DQB1 * 023:01 haplotype was significantly associated with disease risk (p = 0.014, odds ratio (OR) = 5.14) and showed a similar trend in the Cocker spaniel.

This haplotype has sequence similarities to human major histocompatibility complex alleles associated with susceptibility to type 1 diabetes (89).

This haplotype is related to one associated with hypoadrenocorticism in the Nova Scotia duck tolling retriever.

Specific assortments of MHC alleles or haplotypes have been associated with an increased risk for the development of diabetes and auto immune diseases in humans.

Specific haplotypes have been associated with an increased risk for the development of diabetes and auto immune diseases in humans.

This indicated that the over-representation of certain haplotypes occurred at the onset of breed creation as a result of small founder numbers, and / or that it was associated with artificial genetic bottlenecks that were subsequently masked by a return to random selection.

In this study the authors described suggestive associations between post-mortem histological observations and IGF1 haplotype status, the latter which is known to be highly associated with animal size [38,45].

The low number of different DLA class I and II haplotypes in English bulldogs was associated with an imbalance in the relative frequency of each haplotype.

Consistent with the pathogenetic hypothesis of increased serotonin transporter activity in OCD, we showed that a haplotype containing the higher - expressing allele at each of several SLC6A4 loci is significantly associated with increased genetic susceptibility to OCD.

Confirmation that a specific haplotype of the dopamine transporter gene is associated with combined - type ADHD