Sentences with phrase «haplotypes from»

mtDNA sequences from the 166 individuals were aligned with published sequences from 17 additional individuals, resolving 52 unique haplotypes from a consensus length of 410 bp.

Haplotypes in clade A included all individuals sampled in southern California, plus some haplotypes from northern California.

«Assembly - based structural variation and haplotypes from targeted sub-Megabase DNA molecules»

Their content is optimized for genetic mapping in the Collaborative Cross and Diveristy Outbred populations; for discriminating haplotypes from common laboratory strains and substrains; and for evaluating the ancestry of wild - caught mice.

By identifying haplotypes from single - molecule reads, the authors were able to construct phylogenetic trees of the leukemic cells in a single patient, something that could only be done on the 454 platform.

This requires the development of powerful bioinformatic approaches that allow prediction of haplotypes from numerous variants, and the classification of haplotypes into functionally related categories, in order to identify those specific sequence variants, or combinations of variants, associated with the disease phenotype.

Not exact matches

By linking the Y chromosome lineages with genealogical information derived from written records, the researchers say it's now possible to define Y haplotypes for certain founder stallions.

Apart from a few private Northern European haplotypes, all modern horse breeds included in the study clustered into a roughly 700 - year - old haplogroup, transmitted to Europe by the import of Oriental stallions, they report.

The D1 haplotype likely developed after early humans moved into the area from elsewhere in Asia.

The new money should spur collaborations between scientists from Canada and other countries; the haplotype map project, for example, also involves significant contributions from the United States and the United Kingdom.

Professor Sherwin, of the UNSW School of Biological, Earth and Environmental Sciences, said the advantageous mutation then spread rapidly through the population, with the proportion of birds carrying Haplotype H increasing from 17 per cent to 47 per cent during the five years of the study.

Right now, researchers must haplotype by analyzing genetic material from large families, or in their absence track gene frequencies in lots of individuals, a statistical process that is «prone to error,» says geneticist Andrew Collins of Southampton University in the United Kingdom.

In 2010, Lo showed that with both parents» haplotypes known, it would be possible to predict the child's genome from the DNA in an expectant mom's blood.

The alleles in question were found on two different haplotypes — a set of alleles inherited by an individual from a single parent — in unrelated individuals.

HXH appeared homozygous for the dog - like haplotype at all but one of these 18 loci, and thus was often indistinguishable from most modern dogs.

We also performed the first example of cross validation using complementary CC resources to verify the effect of sperm curvilinear velocity from the PWK / PhJ haplotype on chromosome 2 in an independent population across multiple generations.

Mendez et al. identify a Y chromosome haplotype that has not been characterized before and, with more work, they determine that it is nearly identical to a small group of Y chromosomes from Cameroon.

Inferring demographic history from a spectrum of shared haplotype lengths.

Variations in this marker allowed them to determine which two of the parents» four genes were passed on to children suffering from ADHD, a technique known as haplotype - based haplotype relative risk analysis.

We also looked at gene expression in B - cell lymphomas, comparing samples from individuals with risk or non-risk haplotypes.

Inferring demographic history from a spectrum of shared haplotype lengths Harris, K. and R. Nielsen.

«Seven out of eight ES cell lines derived from (parthenogenetic) embryos after MRT (spindle transfer) showed no or very low persistence of the mtDNA haplotype that was carried over with the nuclear DNA.

Hirano, Egli and colleagues have shown that in unusual cases, stem cell clones derived from MR eggs can show substantial drift towards the donors mtDNA haplotype after low level mtDNA carryover during the MR procedure.

Omics techniques employed in our group range from whole genome sequencing and epigenomic techniques, to single cell / single strand DNA sequencing (Strand - seq; see Figure 1), the latter of which enables haplotype - resolved studies of genetic variation and genome instability.

The deCODE team, working with doctors and researchers at Iceland's National University Hospital and the Icelandic Heart Association, identified the PDE4D gene and significant haplotypes by analyzing detailed genotypic data from some 1800 participants in its stroke program, both patients and unaffected relatives, from across Iceland.

On further culture or after subcloning this ES cell line at various times (passages), this particular mtDNA haplotype showed essentially random drift, with cells carrying anything from 0 to 100 %.

The Y - chromosome haplotype reconstructed for CGG10023 was distinct from those Y - chromosome haplotypes present in the modern horses, supporting previous hypotheses that domestication was associated with a significant loss of Y - chromosomal diversity (12, 26).

We have identified a Y - chromosomal lineage that is unusually frequent in northeastern China and Mongolia, in which a haplotype cluster defined by 15 Y short tandem repeats was carried by approximately 3.3 % of the males sampled from East Asia.

A machine - learning methodology (decision - tree induction) allows to induce generalized pharmacogenomic translation models from known haplotype — tables that are able to infer the metabolizer status of individuals from their genotype profiles.

We developed a new approach to sequence generation for targeted base updates and used data from new genome mapping technologies and single haplotype resources to identify and resolve larger assembly issues.

Beta - Globin Haplotypes and Alpha - Thalassemia 3.7 kb Deletion in Sickle Cell Disease Patients From the Occidental Brazilian Amazon

We describe βS and βC haplotypes and α - thalassemia 3.7 kb genotypes from SCD patients Fundacao Hospitalar de Hematologia e Hemoterapia do Amazonas, Manaus, AM.

199/3: 15 Imputation of rare variants from the new Haplotype Reference Consortium identifies associations missed by 1000 Genomes.

The genes were identified through population - and genome - wide linkage scans and association analyses of at - risk haplotypes utilizing genetic and clinical data from the 17,000 participants in deCODE's obesity program in Iceland.

9,961 individuals from the UK Household Longitudinal Study were genotyped using the Illumina HumanCoreExome array and variants imputed to the 1000 Genomes Project and UK10K haplotypes.

Haplotype dimorphism in a SNP collection from Drosophila melanogaster K. Teeter, M. Naeemuddin, R. Gasperini, E. Zimmerman, K.P. White, R. Hoskins and G. Gibson J. Expt.

We define these cases as distinct from instances of selection on standing introgressed variation (SI), in which an introgressed haplotype initially segregated neutrally and subsequently underwent positive selection.

DBA / 1 and DBA / 2 differ at a large number of loci (including the MHC H2 haplotype) which is most likely results from residual heterozygosity in the strain when the substrains were separated.

As a consequence, the possibility has been raised that admixture did occur, but the early Europeans of modern anatomy were not too different genetically from Neandertals, or else that most Neandertal haplotypes were lost through a process of lineage sorting, i.e. by genetic drift [5].

Haplotypes are particular DNA sequences that are inherited entirely from a dog's mom (maternal) or dad (paternal).

No genes that produce abnormal proteins were found, but instead the elevated risk appears to come from groups of tightly - linked DNA sequences called «haplotypes» that regulate the expression of protein - coding genes.

Part of the large A1a haplogroup, this haplotype is found in village dogs from across the globe (outside of Asia).

In this project, we proposed to characterize haplotypes, in over 1200 dogs from 50 pure AKC breeds using DNA sequencing.

Paternal haplotypes were determined from the 44 male dogs in the group based upon a panel of six Y - STR markers, including 650.79.2, 990.35.4, MS34A, MS34B, MS41A, and MS41B [21, 22].

The populations that were tested evolved from one major and three minor paternal haplotypes and three major and two minor maternal haplotypes.

Therefore, the maternal haplotypes seen in English bulldogs support the general belief that English bulldogs evolved from Mastiff - type dogs crossed with brachycephalic breeds such as the Pug [1].

Doing a genetic test and subsequently eliminating an individual from the breeding population may not be the best strategy, as by targeting a particular allele at one genetic locus for removal from the gene pool of a particular breed, breeders may in fact increase allele frequency of genetic variants on alternative haplotypes at the same, or a different locus, that are recessively deleterious.

The odds ratio of dogs with a risk haplotype being aggressive to humans compared with those having a protective haplotype varied from 4.4 to 9.0.

The same haplotypes were recovered from both sequencing methods indicating no sequencing method bias.

The northern islands had nine closely related haplotypes while the southern islands had five haplotypes that were more distant from each other (Fig. 2).