Sentences with phrase «harboring tumor suppressor»
Synthetic lethality - based strategy has been developed to identify therapeutic targets in cancer harboring tumor suppressor gene mutations, as exemplified by the effectiveness of PARP inhibitors in BRCA1 / 2 - mutated tumors.
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«This study provided a conceptual framework for the discovery of «traceable» targets in cancers harboring specific tumor suppressor deficiencies.»
These three chromosome arms harbor well - known oncogenes and tumor suppressor genes that have been shown to undergo copy number alterations in many cancers, including BC (Vogelstein et al., 2013).