Sentences with phrase «have genes sequenced»

Visions of the Future Someday soon, people may carry cards bearing their genome profiles; have genes sequenced at birth, at maturity, and in old age; and use genetic testing to understand and design treatments for medical conditions.

Therefore, to establish the relative frequency of neutralizing clones within the VHH repertoire, individual sequences were aligned to both the known neutralizing VHH sequences and their most likely germ line V gene sequences and the percentage identity to the neutralizing VHH plotted (Fig. 5C, D).

Analysis of the DNA and encoded amino acid sequences of A14 and B9 revealed that the first two are clonal variants which aligned most closely to the germ line denoted VHH Vg (T Verrips, unpublished data) and that the sequence of B21 is highly divergent from both and also aligns to a different germ line V gene sequence Vu.

The exact composition of germline V gene sequences in an individual has been difficult to determine due to -LSB-...]

The exact composition of germline V gene sequences in an individual has been difficult to determine due to the highly repetitive nature of the genomic sequences encoding these segments, thus limiting our understanding of humoral immune responses.

Not exact matches

To date, no Canadian court has questioned the patentability of isolated gene sequences.

Given the similarities between the Canadian Patent Act and its U.S. counterpart for the definition of «invention», the Canadian Patent Office has for many years granted claims like Myriad's to isolated gene sequences and continues to do so.

That's attached to the progress of sequencing technology, the ability to edit cells, and other gene editing approaches have been transformative in the immunotherapy world in recent years.

Speaking about the film recently in Los Angeles, Cera — who in this film, takes some refreshingly bold steps away from his usual one - note nerd persona — and co - writer / director Edgar Wright (who also did the zany cult classics Shaun of the Dead and Hot Fuzz) discussed the meaning of the film, the stretching Cera had to go through for the role, and the way in which the film's hyperkinetic action sequences are really just the same as the dance scenes in Grease or a Gene Kelly movie.

It is a term used by people grasping at straws to continue dismissing evolution even as the evidence builds faster than ever at the gene sequencing level (ie, most of you agree that drug resistant bacteria have evolved but the term MACRO evolution is misused intentionally so you could continue to dismiss science to save faith; pun intended).

Blasting GM DNA into a plant arbitrarily and out of a sequence of genes that has evolved over hundreds of millions of years, in a manner aimed to optimise the functioning of an organism, is risky and unpredictable, and bound to destabilise the biochemistry of the plant.

The DNA segments that carry genetic information are called genes, but other DNA sequences have structural purposes, or are involved in regulating the expression of genetic information.

«Epigenetic marks are physical alterations to the DNA that do not change the sequence of a gene, and thus have the potential to be reversed,» said Hurd.

From the sequence data, they found gene variants indicating that the man had dark skin and eyes.

«If we could use gene editing to remove the sequences in an embryo that cause sickle cell disease or cystic fibrosis, I would say not only that we may do so, but in the case of such severe diseases, we have a moral obligation to do so.»

An international team led by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) has developed a new technique for identifying gene enhancers — sequences of DNA that act to amplify the expression of a specific gene — in the genomes of humans and other mammals.

Now that genomes that can be sequenced quickly and cheaply, deadly microbes have nowhere to hide from the gene police.

In fact, the MESA researchers had included 46 different variants of the gene in their sequencing database.

The estimate of the number of human genes has been repeatedly revised down from initial predictions of 100,000 or more as genome sequence quality and gene finding methods have improved, and could continue to drop further.

Researchers have sequenced the genome of the mould that causes blight and found it keeps a huge arsenal of potato - destroying genes, ready to evolve around whatever defences taters can muster.

Using gene sequencing tools, scientists from Johns Hopkins Medicine and the University of British Columbia have found a set of genetic mutations in samples from 24 women with benign endometriosis, a painful disorder marked by the growth of uterine tissue outside of the womb.

Bingwei Lu, a neuroscientist at Stanford University in California, has shown that a microRNA sequence which suppresses certain genes is linked to the death of brain cells in fruit flies.

I had zero computer experience; in fact, I could barely type, but a postdoc in the lab helped me do a BLAST search using my gene's protein sequence as a query.

In recent years, epigenetics researchers have made great strides in understanding the many molecular sequences and patterns that determine which genes can be turned on and off.

The nucleation gene appears to be unrelated to any of the more than a million genes that have been sequenced to date from various organisms.

In the new study, the researchers sequenced the entire genome of mice that had undergone CRISPR gene editing in the team's previous study and looked for all mutations, including those that only altered a single nucleotide.

And a dog genome sequence has made the animals an even more useful model by quickening the search for disease - causing genes.

After gene mapping we had several candidate regions to choose but exome sequencing quickly identified the actual mutation.

He and his colleagues have been trawling the world's oceans for microbes and sequencing their genes.

With the successful completion of genome - sequencing projects, science's knowledge of genes and proteins has increased exponentially.

The idea of «reversal drives,» which would overwrite mutated genes with the original sequence, often arises as a promising solution to gene drives gone wild.

The Tetrahymena intervening sequence (IVS) has been inserted into the gene for the alpha - donor fragment of beta - galactosidase in a recombinant plasmid.

Use or production of a full - length gene in which the listed sequence constitutes a short embedded part would fall within the purview of a claimed patent...

On the other hand, by deciding that an EST sequence does not provide an adequate written description of a claim directed to «a gene,» the PTO has preserved the possibility for a gene itself to be patented once its full - length sequence is determined.

By contrast, in more than 90 % of endometrial cancers, the gene has undergone hypermethylation, an epigenetic modification that doesn't change its DNA sequence but renders it inactive.

After gene - typing about 3,000 people, Sturm found that how OCA2 is expressed — and how much pigment a person has — is strongly linked to three single nucleotide polymorphisms (SNPs), or single letter variations, in a DNA sequence near the OCA2 gene.

Within the PTO, controversy has continued as to whether ESTs themselves are patentable, to say nothing of whether the claims can and will cover the full - length gene sequences.

More recently, it has become clear that slight variations in the regulatory sequences that determine when a gene is switched on,...

Since the 1970s, scientists have been isolating proteins and laboriously determining their gene sequences.

Molecular geneticist Cheng Chi Lee, developmental biologist Gregor Eichele, and their co-workers at the Baylor College of Medicine in Houston have isolated a gene in mice and humans that shares 44 % of the amino acid sequence of the period (per) gene of the fruit fly Drosophila melanogaster.

Using a combination of old - fashioned clinical observation and modern biochemical analysis, he has shown that a person's appetite and their eating behavior can be linked to specific genes — and that even a tiny defect such as the absence of a single nucleic acid in a sequence of DNA can lead to runaway weight gain.

This marks the third of the monk's seven genes that researchers have precisely identified, and the first since the late 1990s, before the genome sequencing boom.

Sequencing the genome of one such organism, King and her colleagues found genes that code for pieces of the same proteins used for the binding of cells and communication between cells in animals — functions that would be unexpected in such an organism.

Next, he synthesised 50,000 DNA strands with sequences that almost matched parts of the 24 genes involved in lycopene production, but with a range of variations that he hoped would affect the amount of lycopene produced.

The human (and all the other) genome projects were predicated on the reasonable assumption that spelling out the full sequence of genes would reveal the source of that diversity of form and attributes that so readily distinguish worm from fly, mouse, chimp and human.

But researchers had never managed to sequence Mendel's gene for seed color, and the pea genome is too huge to go fishing for it, says co-author Norman Weeden, a pea researcher at Montana State University.

No one is arguing that Lamarck got everything right, but over the past decade it has become increasingly clear that environmental factors, such as diet or stress, can have biological consequences that are transmitted to offspring without a single change to gene sequences taking place.

So we sequenced a gene involved in cell growth and found a correlation in about 85 percent of the patients: If you had a certain mutation in the EGFR gene, you responded to the drug; if you didn't have the mutation, you didn't.

Experiments on it have illustrated what genes are made of, confirmed Darwinian evolution, and helped sequence the human genome.

The two proteins have different biochemical properties and recognize different DNA sequences, so these properties create more options for gene - editing,» said Dr. Olson, who holds the Pogue Distinguished Chair in Research on Cardiac Birth Defects, the Robert A. Welch Distinguished Chair in Science, and the Annie and Willie Nelson Professorship in Stem Cell Research.