Not exact matches
Immunotherapy is praised by researchers because it is targeted, focusing on cancerous
cells rather than
healthy tissue, as well as potentially durable.
But in the following hours and days, the body's self - defense mechanisms backfire: White blood
cells come in to clean up dead
tissue, which causes massive inflammation, which in turn triggers
healthy cells in the surrounding
tissue to self - destruct in a process called apoptosis.
Since PSMA's limited on normal
cells, the therapy should hammer away at tumors while letting
healthy tissues do their job.
Millet is one of the least allergic grains out there and it's mineral and vitamin content helps boost energy and build
healthy cells and
tissue.
If the egg is fertilized by a sperm
cell, it stays in the uterus and grows into a baby, using that extra blood and
tissue to keep it
healthy and protected as it's developing.
Instead, IsoLove re-hydrates
tissue to normal,
healthy levels, and helps maintain the integrity of the vaginal
cell structure and ecosystem.
It also makes
tissue and
cell development a lot more
healthy as well.
When you have anemia, your blood doesn't have enough
healthy red blood
cells to carry oxygen to your
tissues and to your baby.
Anemia — a condition in which you don't have enough
healthy red blood
cells to carry adequate oxygen to your
tissues — due to blood loss during delivery
Eating enough protein is essential for
healthy development of new
cells in the placenta and maternal
tissues and encourages
healthy blood production.
Cancer
cells travel around the body and begin to attack
healthy tissue in a process called metastasis.
She demonstrated that early experience leads to lasting changes in the molecular structure of the brain and discovered a gene involved in the spread of brain cancer
cells into
healthy brain
tissue.
While they're essential for helping the body fend off attacks, if something goes awry, B -
cells can generate antibodies that attack
healthy tissues.
On Thursday, the United Nations» member states will consider two resolutions: One resolution would ban all human cloning methods, including efforts to use cloned embryonic stem
cells to try and generate
healthy tissues, or to treat degenerative diseases such as Parkinson's.
For unknown reasons our immune system attacks
healthy cells,
tissues and organs in a process called autoimmunity, which can result in diseases such as multiple sclerosis, type 1 diabetes, lupus or rheumatoid arthritis.
Gravekamp thinks the radioactive bacteria affected metastatic tumours most because
cells there were still rapidly multiplying, leaving their chromosomes more open to damage than those in
healthy tissues or in the original tumour.
To avoid the risk of injected
cells destroying
healthy tissue, Th17
cells that are reactive to tumours but not to normal
tissues would have to be identified, Dong cautions.
As might be expected of an autoimmune disease, where the immune system turns on
healthy tissue, all the genes play a role in controlling the growth and multiplication of
cells in the immune system.
Sutherland says the genes she studies are already silenced in
healthy adult
tissue, so theoretically researchers should be able to design therapies that re-silence them in cancer
cells without side effects.
This early stage research will explore how the virus targets stem
cells and provide the starting point to develop new treatments that seek out the tumour and spare the surrounding
healthy brain
tissue.
In a study published in the journal Science, an international collaboration of investigators from Dana - Farber, Harvard Medical School, Boston Children's Hospital, and the University of Strasbourg uncovered a mechanism that allows key immune system
cells to keep a steady rein on their more belligerent brother
cells, thereby protecting normal,
healthy tissue from assault.
One reason for this is that the tumour
cells invade surrounding,
healthy brain
tissue, which makes the surgical removal of the tumour virtually impossible.
Whether building organs or maintaining
healthy adult
tissues,
cells use biochemical and mechanical cues from their environment to make important decisions, such as becoming a neuron, a skin
cell or a heart
cell.
«Our immune system is made up of specialised
cells that move through blood and
tissue, preventing disease and fighting infection by distinguishing between what is the body's own
healthy tissue and what is foreign.
Developed by Amgen, it uses a modified version of the herpes virus that can't infect
healthy tissue but attacks cancer
cells.
When chlorotoxin is tagged with a fluorescent dye, it will illuminate a tumour — a trick that makes the surgeon's job easier by helping to pinpoint cancerous growth and ensure that all the cancerous
cells are removed and
healthy tissue spared.
Within that sting lies a peptide called chlorotoxin, which has an unusual property — it sticks strongly to tumour
cells while ignoring surrounding
healthy tissue, by binding to a cancer - specific protein called matrix metalloproteinase - 2.
The scientists» findings have wide implications in the effort to understand how organs are sculpted into their shapes and how
cells respond to their native mechanical environment both in
healthy tissues and during disease.
Unlike chemotherapy and radiation — which indiscriminately damage
cells and
tissues,
healthy or otherwise — the CD45 - targeting antibodies leave the thymus and the bone marrow, environments critical to the formation of T
cells and innate immune
cells, unharmed.
Another key finding of the research was that the impact of vitamin D on inflammatory disease can not be predicted using
cells from
healthy individuals or even from the blood of patients with inflammation as
cells from the disease
tissue are very different.
Cancer therapies are often harsh because eradicating malignant
cells entails damaging
healthy tissue as well.
Change the size from 10 nanometers to 100 nanometers, and the drugs can end up in the wrong
cells or organs and thereby damage
healthy tissues.
Significant advances have been made in chemotherapy over the past decade, but targeting drugs to cancer
cells while avoiding
healthy tissues continues to be a major challenge.
Compared to people with periodontitis or gingivitis who were otherwise
healthy, one molecule in particular stood out: people with LAD had very high levels of IL - 17 mRNA and IL -17-expressing
cells in their gum
tissue.
The molecule seemed to function as a checkpoint, turning off the T
cell after a period of activity — perhaps to prevent collateral damage to
healthy tissue.
Switching Apc on again made the frenzied
cells morph back into
healthy gut
tissue, which contains intestinal
cells (below, green) and clusters of stem
cells (below
We think this pathway might act to get rid of infected
cells, clearing them out so the infection can not spread to
healthy tissue.
In
healthy breast
tissue, the percentage of
cells expressing molecular marker Ki67 (green) and p27 (red) was low.
In a bid to progress beyond the shotgun approach to fighting cancer — blasting malignant
cells with toxic chemicals or radiation, which kills surrounding
healthy cells in the process — researchers at the Harvard - MIT Division of Health Sciences and Technology (HST) are using nanotechnology to develop seek - and - destroy models to zero in on and dismantle tumors without damaging nearby normal
tissue.
In essence, he says, weak T regs can mature into killer T
cells that weed out other immune
cells mounting attacks on
healthy tissues.
Lupus, or systemic lupus erythematosus, is a progressive, degenerative disease in which the immune system turns against itself, attacking a person's
healthy tissue,
cells and organs.
A more attainable goal may be regenerative
tissue transplants, for example, replacing dying liver
cells in someone with early - stage liver disease with chunks of
healthy stem
cells from a personalized liver organoid.
Therefore, these «self - reactive» T
cells survive destruction within an organ called the thymus, the central immune organ in which T -
cells mature, and attack
healthy cells and
tissues, including melanocytes.
They treated a variety of
healthy tissues and 23 samples of cancer
cells taken from leukemia patients with AG1295, a drug known to selectively block the kinase.
«The exosomes appear to contain the signaling information needed to regenerate
healthy heart
tissue, they are naturally able to permeate
cells, and they have a coating that protects their payloads from degradation as they shuttle from
cell to cell,» said Marbán, senior author of an article in the May 6, 2014 Stem Cell Repo
cell to
cell,» said Marbán, senior author of an article in the May 6, 2014 Stem Cell Repo
cell,» said Marbán, senior author of an article in the May 6, 2014 Stem
Cell Repo
Cell Reports.
But working with human smooth muscle
cells isolated and grown from the
healthy parts of airway
tissue surrounding excised tumors, Benjamin Kalbe and his colleagues applied a large number of odor molecules and watched two of them activate the muscle
cells.
The researchers are developing a potential new immunotherapy strategy for melanoma based on their insights into Autoimmune Polyendocrinopathy Type 1, a rare, inherited disorder in which T -
cells attack
healthy cells and
tissues.
Now scientists have shown that the stem, or progenitor
cells, which should ultimately make
healthy breast
tissue, can also have GT198 mutations that prompt them to instead make a perfect bed for breast cancer.
Dr. Ella Evron and Dr. Ayelet Avraham of the TAU - affiliated Assaf Harofeh Medical Center, together with Prof. Saraswati Sukumar of Johns Hopkins, have found that «gene regulation,» the process that shuts off certain parts of a
cell's DNA code or blueprint in
healthy breast
tissue cells, may also play a critical role in the development of breast cancer.
Investigators at the Cedars - Sinai Heart Institute — whose previous research showed that cardiac stem
cell therapy reduces scarring and regenerates
healthy tissue after a heart attack in humans — have identified components of those stem
cells responsible for the beneficial effects.