Editing GalNAc - T6 out of a colon cancer cell line changed its growth form to one more closely resembling
healthy colon tissue.
Kirstine Lavrsen and colleagues at the University of Copenhagen discovered that GalNAc - transferase 6, known as GalNAc - T6, one of 20 polypeptides that initiate GalNAc - type O - glycosylation of proteins, was absent in
healthy colon tissue but abundant in colon cancer tissue.
Not exact matches
The protein expression and activity of MMP9 is undetectable in most
healthy adult
tissues, including the
colon and intestine, but it is highly expressed in a variety of inflammatory states.
When the team first examined the microbial composition of intestinal biopsies, they saw the bacterial strains in the tumors and surrounding
tissues of
colon cancer patients differed from the bacterial strains in the gut of
healthy individuals.