In her project, Sipkins will investigate molecular characteristics of tissue microenvironments, or «niches,» within the bone marrow and how normal,
healthy hematopoietic stem cells, which give rise to the many kinds of blood cells, compete with malignant cells to occupy these coveted niches.
Not exact matches
For now, Porteus and his team found that their corrected human
hematopoietic stem cells seemed to behave like normal,
healthy human
hematopoietic stem cells.
Subsequently, the
hematopoietic system has to be replaced with
stem cells from the blood of a
healthy donor.
Isolation and characterization of mesenchymal adult bone marrow
stem cells (MSC) and
hematopoietic stem cells (HSC) from
healthy donors and patients with leukemia.
So mutations in the
hematopoietic stem cells of
healthy volunteers seemed to accumulate over time.