Comparing levels of S1PR2 in people with MS, mice with a similar disease, and
healthy humans and mice, the team found the groups with MS or the MS - like disease had higher levels of the protein, meaning the blood - brain barrier was more permeable.
Then they compared the results with the genetically modified mice, as well with
healthy humans and mice.
Not exact matches
Compared with
mice with cells from
healthy people as well as non-chimera
mice, those whose brains had
human schizophrenia cells were more afraid to explore a maze, more anxious, more antisocial, less able to feel pleasure (from sipping sugar water), worse at remembering,
and more sleepless — all of which characterize people with schizophrenia, too.
In
human cells
and in
mice, the virus infected
and killed the stem cells that become a glioblastoma, an aggressive brain tumor, but left
healthy brain cells alone.
In addition to looking at
mouse models of diabetes, the researchers also showed that exposure of
human pancreatic islet cells — both from
healthy donors
and from patients with Type 1 diabetes — to fasting - mimicking diet in a dish stimulated insulin production.
Managing the microbiome instead of pummeling it with antibiotics has produced impressive results in chicken
and mice studies, pointing the way not just to future
human treatments but also to a
healthier food supply.
They injected the particles directly into
mice with an experimental
human brain cancer,
and into the brains of
healthy mice for use as comparison.
Before Katlyn showed up at NIH, the doctors there were already well prepared: They had inserted
healthy human ADA genes into a modified
mouse retrovirus — a type of virus that can enter
human cells
and transfer new genetic material right into the DNA strands in their nuclei.
In subsequent experiments, Pissios
and colleagues found that NNMT correlated positively with Sirt1
and a
healthy metabolic profile in
mice,
and also showed that
humans with low cholesterol
and low triglycerides exhibited high levels of NNMT
and Sirt1 in their livers.
To address this question, the Penn researchers examined lymphocytes donated by
healthy human females as well as «naïve,» or unstimulated T
and B cells from female
mice.
Walford's new research is based on the fact that in
mice and humans, the immune system malfunctions during aging, losing the ability to distinguish between
healthy cells
and invasive pathogens such as bacteria
and viruses.
Broccoli sprout extract protects against oral cancer in
mice and proved tolerable in a small group of
healthy human volunteers, the University of Pittsburgh Cancer Institute (UPCI), partner with UPMC CancerCenter, announced today at the American Association for Cancer Research (AACR) Annual Meeting in Philadelphia.
The current study found that
mice meant to serve as a model of ischemic
human heart failure (weaker blood flow after a heart attack) had higher levels of activated, pro-inflammatory macrophages, monocytes, dendritic cells
and T cells trafficking between their hearts
and spleens than did control
mice with
healthy hearts.
Most convincing of all, Knight believes, is that when samples of gut bacteria from the jet - lagged
humans were transplanted into
healthy mice, the animals gained weight, showed increased blood sugar,
and had a higher body fat content compared with animals given the bacteria of participants before their flight.
While past attempts to treat melanoma failed to meet expectations, an international team of researchers are hopeful that a compound they tested on both
mice and on
human cells in a petri dish takes a positive step toward creating a drug that can kill melanoma cancer cells without harming nearby
healthy cells.
Next steps include He's collaboration with Piedmont Atlanta Hospital to retrieve T cells, liver cancer cells
and healthy tissue normally removed from patients during surgery, put the
mouse receptor genes on these T cells
and monitor in a dish both how those cells now fight the tumor
and react to
healthy human tissue.
Researchers study lab
mice and other species in the hunt to understand the
human body —
and what will keep it
healthy
To answer basic research questions like these, investigators study bacteria, viruses, fungi, animal cells
and human cells (both
healthy and cancerous) grown in the lab,
and tumors in animals, such as
mice and rats.
This investigative new cancer therapy was developed from the exciting research results of studying natural cancer resistance in a unique strain of lab
mouse (SR / CR
mice)
and in some
healthy humans.
A few interesting articles in early life
human microbiome, plus: A comparison between Staphylococcus epidermidis commensal
and pathogenic lineages from the skin of
healthy individuals living in North American
and India; A new tool to reconstruct microbial genome - scale metabolic models (GSMMs) from their genome sequence; The seasonal changes in Amazon rainforest soil microbiome are associated with changes in the canopy; A specific class of chemicals secreted by birds modulates their feather microbiome; chronic stress alters gut microbiota
and triggers a specific immune response in a
mouse model of colitis;
and evidence that the short chain fatty acids profile in the gut reflects the impact of dietary fibre on the microbiome using the PolyFermS continuous intestinal fermentation model.
Researchers grew
human spinal cord neurons from stem cells
and injected them into
healthy mice, where they successfully connected with other neurons.
Immunoblot analysis using
mouse monoclonal antibody to
human IgM detected IgM to cytomegalovirus (CMV)- specific proteins (150, 42, 38, 32,
and 28 kDa) in 74 (38 %) of 197 seropositive serum samples from 197 individuals in three subject groups: 43 surgical patients, 31 patients with solid tumors,
and 123
healthy individuals.
«Theranostics» Simultaneously Kill
and Image Prostate Cancer Cells Experimenting with
human prostate cancer cells
and mice, cancer - imaging experts developed a method for finding
and killing malignant cells while sparing
healthy ones.
The combination of fatty acids used by the python to accomplish its own,
healthy enlargement seems to have the same effect in lab
mice,
and now researchers hope to apply the same principle to the treatment of
human heart problems.
It also seems that
humans are exquisitely adapted to low calorie environments (unlike
mice)
and therefore intermittent fasting would be of limited benefit but a long, sustained fast, might actually «move the needle» toward a more
healthy body.
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and live longer 28.10.2011 Probiotic bacteria LKM512 extends lifespan in animal study 24.10.2011 Animal study: Royal Jelly has life extending properties 18.10.2011 L - Arginine: «the best anti-aging remedy» 02.10.2011 Test - tube study: ashwagandha inhibits Alzheimer's 10.08.2011 Live longer — take carnosine 04.08.2011 Creatine - Q10 combination protects brain cells
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healthy habits can prolong your life by fourteen years 19.03.2011 The rejuvenating effect of 45 minutes» running every day: animal study 28.01.2011 So vitamin E does extend life expectancy... 27.11.2010 Carnosine extends lifespan in animal study 10.11.2010 BCAAs extend lifespan in animal study 28.10.2010 Elderly are fitter with Cordyceps sinensis 08.10.2010 Glucosamine
and chondroitin users live longer 24.06.2010 Rhodiola rosea extends life in animal study 18.06.2010 Runners» testes stay young 10.06.2010 Drink green tea instead of water —
and live longer 24.05.2010 Low - carb diet delays aging
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healthy 26.04.2010 Delay aging without hunger with life extenders in green apples 19.04.2010 Endogenous growth hormone keeps older athletes young 09.04.2010 Men who take ginseng live longer 19.03.2010 Animal study: Canadian longevity stacker works 05.03.2010
Human study: omega - 3 fatty acids delay molecular ageing 08.02.2010 Fish oil lengthens life in animal study 07.02.2010 Curious?
You can help place
healthy cats that aren't suitable as pets in environments where they can flourish, working alongside
humans to control rat
and mice populations.
Animal Humane Society can help place
healthy cats that aren't suitable as pets in environments where they can flourish, working alongside
humans to control rat
and mice populations.