Sentences with phrase «healthy huntingtin»

The cause of Huntington's disease has been known since 1993, but the physical structure of the healthy huntingtin protein proved difficult to discover until now.

The VCP inside mitochondria only interacted with mutant, but not healthy huntingtin protein.

Not exact matches

When the huntingtin gene is deleted at an age older than four months, these mice appeared to stay healthy, despite having lost their huntingtin genes in cells all over their bodies.

That means a healthy parent whose huntingtin gene encodes proteins with 35 repeats may produce a child with 36 repeats.

Next, Grima looked at cell death in cultured neurons with a healthy or a mutant form of Huntingtin, or with a mutant form of Huntingtin that was treated with small amounts of an experimental drug called KPT - 350, one that prevents a nuclear export protein, Exportin - 1, from shuttling proteins and RNA out of the nucleus.

To further explore nuclear transport's role in Huntington's disease, Grima took lab - grown mouse neurons and used chemical switches to a) turn on both an additional healthy copy of the RanGAP1 gene and a mutant version of Huntingtin; b) just turn on the mutant Huntingtin; or c) just turn on a healthy version of Huntingtin.

Neurons with the healthy version of Huntingtin had about 18 percent die off, and neurons with the mutant version of Huntingtin had about 38 percent die off.

Researchers recently inactivated the huntingtin gene in healthy adult mice of different ages.

That's not what we expect when patients are given huntingtin - lowering drugs, which might produce around 50 - 75 % reductions in the mutant and healthy protein.