Not exact matches
There has been a lack of reliable markers, early indicators and risk factors associated with
pancreatic cancer, but this new way of differentiating between
healthy and malignant
tissue offers hope for earlier diagnosis and treatment.»
The predictor accurately differentiated
pancreatic cancer, benign
pancreatic lesions, early stage
pancreatic cancer and
healthy tissue.
The team then selected a subset of data for developing a panel for differentiating between
pancreatic cancer and healthy pancreas tissue and thereafter applied this «Pancreatic Cancer Predictor» to the remaining datasets for independent validation to confirm the accuracy of th
pancreatic cancer and
healthy pancreas
tissue and thereafter applied this «
Pancreatic Cancer Predictor» to the remaining datasets for independent validation to confirm the accuracy of th
Pancreatic Cancer Predictor» to the remaining datasets for independent validation to confirm the accuracy of the markers.
After demonstrating and independently validating that a 5 - gene
pancreatic cancer predictor discriminated between cancerous and
healthy tissue, the researchers applied the predictor to datasets that also included benign lesions of the pancreas, including pancreatitis and early stage cancer.
On average, the
pancreatic cancer patients examined in the study carried 15 LINE - 1 insertions in their tumor DNA that were not in
healthy tissue.
Using miR - 192 levels in the cells, the investigators were able to differentiate with very high certainty between normal and chronically inflamed pancreas
tissue as well as between
healthy pancreas
tissue and
pancreatic cancer.
The failure in
pancreatic cancer treatment is main due to the presence of a dense and poorly vascularized stroma that increase the drug clearance in the tumors rather than the
healthy tissues, decreasing drug bioavailability in the target
tissue and leading to significant side effects.
A new cancer - seeking compound that can trace a
pancreatic tumor's outline with exceptional clarity, then attack cancer cells while leaving
healthy tissues alone, is undergoing tests at the Roswell Park Comprehensive Cancer Center's Photodynamic Therapy Center.