Sentences with phrase «heavy chain gene»

Detection of immunoglobulin heavy chain gene rearrangements in classic hodgkin lymphoma using commercially available BIOMED - 2 primers.

Introns outperform exons in analyses of basal avian phylogeny using clathrin heavy chain genes

Not exact matches

Since genes for the T - cell receptor beta chain were previously shown to be on mouse chromosome 6, all three of the Ig - like multigene families expressed and rearranged in T cells are located on different chromosomes, just as are the B - cell multigene families for the Ig heavy chain, and the Ig kappa and lambda light chains.

The mouse heavy chain immunoglobulin gene contains a tissue - specific enhancer.

Two types of immature B cells, namely fetal liver hybridomas and the leukemic cell line 70Z / 3, both of which have cytoplasmic mu chains but no light chains, were examined for DNA rearrangements of their light chain and heavy chain immunoglobulin genes.

So, instead, they genetically manipulated the genes that controlled the CDRs of the heavy chain - only antibodies, chopping them up and randomly mutating them to generate a varied library of binding sites for their biosensor.

This is in contrast to the well - characterized VRC01 - like family of CD4 - binding site antibodies identified in multiple HIV - positive donors, which share both a heavy chain V gene precursor and unusual features at a DNA sequence level which could allow sequencing - based identification of other similar antibodies in distinct patients [53].

To accomplish this, we used homologous recombination to ablate nonmuscle myosin heavy chain (NMHC) II - B by inserting cDNA encoding green fluorescent protein (GFP)- NMHC II - A into the first coding exon of the Myh10 gene, thereby placing GFP - NMHC II - A under control of the endogenous II - B promoter.

The antigen receptor genes that undergo rearrangements are the immunoglobulin heavy chain (IGH) and light chain loci (IGK and IGL) in B cells, and the T cell receptor gene loci (TRA, TRB, TRG and TRD) in T cells.

The NP - reactive B cells from splenic germinal centers (GC) were recovered by microdissection of frozen tissue sections and their rearranged Ig heavy chain variable region (VH) genes of the V186.2 / V3 families were sequenced.

11 mutations were identified in 3 distinct genes: β - myosin heavy chain (MYH7), α - cardiac actin (ACTC), and Troponin T (TNNT2).

In our second study we found that heterozygous mutations in genes encoding β - myosin heavy chain (MYH7), α - cardiac actin (ACTC1), cardiac troponin T (TNNT2), cardiac myosin - binding protein C (MYBPC3), and alpha - tropomyosin (TPM1) account for 30 % of cases of isolated LVNC in adult patients (Probst et al., 2011).

When people eat a plant - heavy diet, the fiber from the plant matter ferments in the gut and creates short - chain fatty acids, which, in turn, regulate the immune system and influence gene expression in the brain and elsewhere.

Many of the downregulated genes are smooth muscle cytoskeletal elements, including TCAP (titin - cap), TPN1 (tropomyosin), DMD (dystrophin), SMTN (smoothelin), TAGLN (transgelin), MYH11 (smooth muscle myosin heavy chain 11), and CNN1 (smooth muscle calponin 1).