Sentences with phrase «helix forming»

The double strand breaks are created either by site - specific designer zinc finger endonucleases or triple helix forming oligonucleotides that are able to recognise and induce repair of specific mutations in the genome.

Here, we present experiments using a reconstituted fusion system that suggest a simple model in which the complexin accessory helix forms an alternative four - helix bundle with the target - SNARE near the membrane, preventing the vesicle - SNARE from completing its zippering.

The resulting five - strand junction, in which a short helix forms base triples with three separate strands in the Tetrahymena intron, reveals exceptionally dense packing of RNA.

Once in helix form, the crystals can reproduce by diving into two identical helixes, displaying «memory marks» on their structures [source: New Journal of Physics].

The site specific installation disrupts the horizontality of the hallway gallery with looming helix forms swirling towards the ceiling to create a man - made forest for visitors to navigate.

«She based them on the twists of asymmetrical helix forms,» explains ICA head of programmes and curator Katharine Stout, «but they are also about the everyday.»

Not exact matches

Beyond that, it's been thirty + years since amino acids were discovered in fallen asteroids, and just recently they've found two of the four nucleobases that form the rungs of the DNA double helix.

Despite the pursuit of early - stage geographical diversity, seeding, which has been around in one form or another for most of the tournament's history, has kept them apart in the group stage, and this strange double - helix - like relationship does the rest.

The reaction involves binding an RNA or DNA substrate by base pairing to the internal guide sequence (IGS) to form helix P1.

If this helix was a perfectly formed, the canvas would appear blank.

When the fragment bound DNA, a region previously referred to as the «disordered domain» became more ordered and moved along with two helices toward the 3» to 5» exonuclease domain to form the binding groove.

The genetic instructions must be there of course, condensed within the simple elegant spirals of the double helix, but the source of the near infinite variety of forms of life now seems more elusive than ever.

This particular lipid forms tubules called myelin figures, which curl up into the double helix seen in the micrograph.

The model shows the classic double helix of DNA strands going in opposite directions with nucleotides linking to each other across the strands to form base pairs.

Unlike straight L peptides, which can be fairly easily converted to a D form, most biologically active peptides are twisted into helices, and so far there has been no good way to design their mirror - image counterparts on a large scale, said Kim.

They combined the protein with synthetic molecules, known as PNAs, that mimic DNA and bind to the target gene to form a triple helix.

To do so, they engineered a collection of 20 DNA double helices to form a nanotube big enough (15 to 20 nanometers — just over one - billionth of a meter — in diameter) to house the fibrils.

The most conspicuous characteristic of male narwhals is their single extraordinarily long tusk, which is a tooth that projects from the left side of the upper jaw and forms a left - handed helix.

Why does DNA form a double helix?

The molecular triangles are threaded around each other at the same time that the triangles are formed, by a process called «self - assembly», similar to how the DNA double helix is formed in biology.

The helix winds onto nucleosomes to form chromatin, which winds and winds in its turn into formations similar to what you get when you keep twisting the two ends of a string.

First, they occurred quickly and the resulting nucleotides spontaneously paired with each other in water, forming hydrogen bonds like the Watson - Crick base pairs that create the «ladder - rung» pattern inside RNA and DNA helixes.

Natural DNA consists of a ladder frame of ring - shaped deoxyribose molecules (which form the backbone of the double helix) and rungs of bases (which spell out the genetic alphabet).

The structures determined by x-ray crystallography show that the binding pocket of HSP90 is lined by a region that can take the form of a helix or a loop when bound to different inhibitors (see image below).

At the time, biology was all the rage: In 1953, Cambridge University biophysicists Francis Crick and James Watson had discovered that DNA takes the form of a double helix, or a twisted ladder.

Most of the DNA in a cell is in the form of a double - stranded helix, so this is not necessarily a problem for gene - editing applications.

In a new twist on the use of DNA in nanoscale construction, scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory and collaborators put synthetic strands of the biological material to work in two ways: They used ropelike configurations of the DNA double helix to form a rigid geometrical framework, and added dangling pieces of single - stranded DNA to glue nanoparticles in place.

Scientists built octahedrons using ropelike structures made of bundles of DNA double - helix molecules to form the frames (a).

RNA, or ribonucleic acid, is very similar to DNA except that it is happy to live in a single - stranded state (as opposed to DNA's desire to form complementary double - stranded helixes).

Two microRNAs with synergistic effects, one that suppresses tumor growth and another than inhibits tumor promotion, are combined in an RNA triple helix, complexed with a dendrimer to form nanoparticles, which are incorporated with a polymer to form a hydrogel that inhibits tumor growth when applied to the tumor.

Two complementary strands of DNA base pair to form the famous double helix.

It is made up of sequences of the four base pairs A, T, C, and G. Two complementary strands of DNA are attracted to each other to form the famous double helix shape.

HAR1 does not code for a protein but for a long RNA, a type of molecule that guides proteins or modulates their expression.5 We predicted that the HAR1 RNA could fold into a three - dimensional structure because its conserved sequence has palindromic regions that pair up to form a series of interconnected «stems» that look like ladders — think of an untwisted DNA double helix.

The diameter of the helixes varies throughout the structure and the arrangement of these various sections is replicated in other crystals, passing on what could be called a form of genetic code.

For the mutations located in the JH1 kinase domain, we took advantage of the recently solved crystal structure of the JAK1 JH1 domain to detail their localization.21 As shown in Figure 1C, D and E, from 13 JH1 - located mutations, 3 (K1026E, Y1035C and S1043I) are located in the activation loop (A-loop), 4 mutations affect the same residue (F958V, F958C, F958S, F958L) in the hinge region of the kinase domain at the entry of the ATP - binding pocket, 3 others (D895H, E897K and T901R) are located at the top of the kinase domain in the loop formed between two antiparallel β - strands (β2 and β3) and one mutation affects the loop formed between the β - strand - 3 (β3) and the αC helix of the JH1 domain (L910Q).

Helix - shaped plasma crystals, which may be a form of so - called «weird life,» could potentially be found in the rings of Saturn.

Antagonistic Basic Helix - Loop - Helix / bZIP Transcription Factors Form Transcriptional Modules That Integrate Light and Reactive Oxygen Species Signaling in Arabidopsis

Our sequencing techniques have improved * tremendously since February 18th, 1953 when James Watson and Francis Crick first pieced together through the help of other amazing scientists, Maurice Wilkins and Rosalind Franklin, how the nucleotides formed the DNA ladder in the elegant double helix.

Various other PC makers have attempted convertible laptop / tablet hybrids, with Lenovo's ThinkPad Helix arguably offering the best form factor.

Helix Pet Hospital offers patient form (s) online so you can complete them in the convenience of your own home or office.

-802 Pokedex entries -48 Megas -18 Alola variations -3 Primal (Kyogre, Groudon, Dialga)-10 Totem variations -11 major gender variations (Wobbuffet, Meowstic, Pyroar, Jellicent, Frillish, Unfeazant, Hippopotas, Hippowdon, Combee, Heracross, Pikachu)-24 extra Pikachu variations (6 Ash, 5 Cosplay, 7 TEAM, Holiday POKEMON GO, Mystery Dungeon Scarf, Surfing, Balloon from Pokemon Yellow, Balloon from Pikachu Dash, Metal from SSB, Pikachu + Pichu Balloon from Pokemon Puzzle Challenge, 96» Classic, Ditto Pikachu, Fancy, Illustrator, Birthday, Office, Detective, Singing, Pokemon Rumble, Snow, Pikachu Lapras Dash, Waldo, WiiU rumble, HGSS Super Nerd Robot, 2014 World Championship, Pokemon Shuffle)-3 extra Pichu variations (Spiked Eared, Ukelele, Pikachu + Pichu Balloon from Pokemon Puzzle Challenge)-18 extra Arceus variations (Normal, Bug, Dark, Dragon, Electric, Fairy, Fighting, Fire, Flying, Ghost, Grass, Ground, Ice, Poison, Psychic, Rock, Steel, Water,???)-27 extra Unown variations -19 extra Vivillion variations (Archipelago, Continental, Elegant, Garden, High Plains, Icy Snow, Jungle, Marine, Meadow, Modern, Monsoon, Ocean, Polar, River, Sandstorm, Savanna, Sun, Tundra, Poké Ball, Fancy)-2 extra Mewtwo variations (Shadow, Mega Shadow Y)-1 extra Mimikyu Busted Dream form -7 extra Minior Cores (Red Core, Orange Core, Yellow Core, Green Core, Blue Core, Indigo Core, Violet Core)-1 extra Musharna variation (Awake form)-1 extra Raichu variation (Holiday POKEMON GO)-1 extra Marshadow variation -3 extra Zygarde Formes -1 extra Greninja variation (Ash)-1 extra Gyarados variation (Lake of Rage)-1 extra Jynx variation (original black skin)-6 extra Arbok variations (each region)-1 extra Purple Kecleon variation -1 extra XD001 Lugia variation -3 extra Castform variations -3 extra Deoxys variations -2 extra Burmy variations -2 extra Wormadam variations -1 extra Cherum variation -1 extra Shellos variation -1 extra Gastrodon variation -6 extra Rotom variations -1 extra Giratina variation -1 extra Shaymin variation -1 extra Tornadus variation -1 extra Thundurus variation -1 extra Landorus variation -1 extra Basculin variation -1 extra Darmanitan variation -3 extra Deerling variations -3 additional Sawsbuck variations -1 extra Keldeo variation -1 extra Meloetta variation -4 extra Genesect variations (includes 1 High Speed Form)-4 extra Flabebe variations -5 extra Floette variations -4 extra Florges variations -9 extra Furfrou variation -1 extra Aegislash variations -3 extra Pumpkaboo variations -3 extra Gourgeist variation -1 extra Xerneas variation -1 extra Hoopa variation -1 extra Haunter variation (Original sprite)-1 extra Koffing variation (upside down from R / B / G)-1 extra Ivysaur variation (Standing from R / B / G)-1 extra Golbat variation (Crazy giant mouth from R / B)-1 extra Munchlax variation (Flying)-1 extra Magearna color variation -2 Kyurem variations (Black Active and White Active forms)-1 Dragon Skeleton -1 extra Cloyster variation (old horizontal sprite)-1 extra Exeggcute variation (old R / B sprite)-1 extra Excadrill variation (Gen 5 beta with backwards body design)-1 additional Kingler variation (original double giant claw sprite)-3 Pokemon GO Eggs -11 Fossils (Helix Fossil, Dome Fossil, Old Amber, Root Fossil, Claw Fossil, Skull Fossil, Armor Fossil, Cover Fossil, Plume Fossil, Jaw Fossil, Sail Fossil)-28 Pokeball variations -27 Evolution Items -47 Mega Stones -1 Key Stone -50 Gym badges -2 «GHOST» Pokemon (original R / B / Y and FR / LG)-20 Beta Gen 1 Unused Pokemon (Dragon4, Poliwag beta, Nyosuka / Poliwhirl beta, Kokana / Weedle beta, Staryu beta, Blastoise beta, Lapras beta, Dragonair beta, Rokku / Rydon beta, Kasanagi and Kasanagi evolution unused beta Pokemon, Gengar beta, Nidorino beta, Godzillante, Gorillaimo, Buhi, Papyo, Koffing, Shellder, Cloyster)-11 Beta Gen 2 Unused Pokemon (Gonoguma, Kurusu, Happa, Unnamed turtle, unnamed creature, black skinned promo design Bellossom, Ladyba beta, marril beta, Baku / Quillfish beta, Girafarig beta, Raikou / Suicune beta)-7 Beta Gen 3 Unused Pokemon (Blaziken / Latias or «Latiken», Torchic beta 1, Torchic beta 2, Treecko beta, Groudon beta, Shellos beta, Gastrodon beta)-6 Glitch Pokemon (Missingno, Golden Bulbasaur,??????, Kabutops Fossil Form, Aerodactyl Fossil Form, Bag Egg)-1 Beta Gen 6 Pokemon (Hooform -7 extra Minior Cores (Red Core, Orange Core, Yellow Core, Green Core, Blue Core, Indigo Core, Violet Core)-1 extra Musharna variation (Awake form)-1 extra Raichu variation (Holiday POKEMON GO)-1 extra Marshadow variation -3 extra Zygarde Formes -1 extra Greninja variation (Ash)-1 extra Gyarados variation (Lake of Rage)-1 extra Jynx variation (original black skin)-6 extra Arbok variations (each region)-1 extra Purple Kecleon variation -1 extra XD001 Lugia variation -3 extra Castform variations -3 extra Deoxys variations -2 extra Burmy variations -2 extra Wormadam variations -1 extra Cherum variation -1 extra Shellos variation -1 extra Gastrodon variation -6 extra Rotom variations -1 extra Giratina variation -1 extra Shaymin variation -1 extra Tornadus variation -1 extra Thundurus variation -1 extra Landorus variation -1 extra Basculin variation -1 extra Darmanitan variation -3 extra Deerling variations -3 additional Sawsbuck variations -1 extra Keldeo variation -1 extra Meloetta variation -4 extra Genesect variations (includes 1 High Speed Form)-4 extra Flabebe variations -5 extra Floette variations -4 extra Florges variations -9 extra Furfrou variation -1 extra Aegislash variations -3 extra Pumpkaboo variations -3 extra Gourgeist variation -1 extra Xerneas variation -1 extra Hoopa variation -1 extra Haunter variation (Original sprite)-1 extra Koffing variation (upside down from R / B / G)-1 extra Ivysaur variation (Standing from R / B / G)-1 extra Golbat variation (Crazy giant mouth from R / B)-1 extra Munchlax variation (Flying)-1 extra Magearna color variation -2 Kyurem variations (Black Active and White Active forms)-1 Dragon Skeleton -1 extra Cloyster variation (old horizontal sprite)-1 extra Exeggcute variation (old R / B sprite)-1 extra Excadrill variation (Gen 5 beta with backwards body design)-1 additional Kingler variation (original double giant claw sprite)-3 Pokemon GO Eggs -11 Fossils (Helix Fossil, Dome Fossil, Old Amber, Root Fossil, Claw Fossil, Skull Fossil, Armor Fossil, Cover Fossil, Plume Fossil, Jaw Fossil, Sail Fossil)-28 Pokeball variations -27 Evolution Items -47 Mega Stones -1 Key Stone -50 Gym badges -2 «GHOST» Pokemon (original R / B / Y and FR / LG)-20 Beta Gen 1 Unused Pokemon (Dragon4, Poliwag beta, Nyosuka / Poliwhirl beta, Kokana / Weedle beta, Staryu beta, Blastoise beta, Lapras beta, Dragonair beta, Rokku / Rydon beta, Kasanagi and Kasanagi evolution unused beta Pokemon, Gengar beta, Nidorino beta, Godzillante, Gorillaimo, Buhi, Papyo, Koffing, Shellder, Cloyster)-11 Beta Gen 2 Unused Pokemon (Gonoguma, Kurusu, Happa, Unnamed turtle, unnamed creature, black skinned promo design Bellossom, Ladyba beta, marril beta, Baku / Quillfish beta, Girafarig beta, Raikou / Suicune beta)-7 Beta Gen 3 Unused Pokemon (Blaziken / Latias or «Latiken», Torchic beta 1, Torchic beta 2, Treecko beta, Groudon beta, Shellos beta, Gastrodon beta)-6 Glitch Pokemon (Missingno, Golden Bulbasaur,??????, Kabutops Fossil Form, Aerodactyl Fossil Form, Bag Egg)-1 Beta Gen 6 Pokemon (Hooform)-1 extra Raichu variation (Holiday POKEMON GO)-1 extra Marshadow variation -3 extra Zygarde Formes -1 extra Greninja variation (Ash)-1 extra Gyarados variation (Lake of Rage)-1 extra Jynx variation (original black skin)-6 extra Arbok variations (each region)-1 extra Purple Kecleon variation -1 extra XD001 Lugia variation -3 extra Castform variations -3 extra Deoxys variations -2 extra Burmy variations -2 extra Wormadam variations -1 extra Cherum variation -1 extra Shellos variation -1 extra Gastrodon variation -6 extra Rotom variations -1 extra Giratina variation -1 extra Shaymin variation -1 extra Tornadus variation -1 extra Thundurus variation -1 extra Landorus variation -1 extra Basculin variation -1 extra Darmanitan variation -3 extra Deerling variations -3 additional Sawsbuck variations -1 extra Keldeo variation -1 extra Meloetta variation -4 extra Genesect variations (includes 1 High Speed Form)-4 extra Flabebe variations -5 extra Floette variations -4 extra Florges variations -9 extra Furfrou variation -1 extra Aegislash variations -3 extra Pumpkaboo variations -3 extra Gourgeist variation -1 extra Xerneas variation -1 extra Hoopa variation -1 extra Haunter variation (Original sprite)-1 extra Koffing variation (upside down from R / B / G)-1 extra Ivysaur variation (Standing from R / B / G)-1 extra Golbat variation (Crazy giant mouth from R / B)-1 extra Munchlax variation (Flying)-1 extra Magearna color variation -2 Kyurem variations (Black Active and White Active forms)-1 Dragon Skeleton -1 extra Cloyster variation (old horizontal sprite)-1 extra Exeggcute variation (old R / B sprite)-1 extra Excadrill variation (Gen 5 beta with backwards body design)-1 additional Kingler variation (original double giant claw sprite)-3 Pokemon GO Eggs -11 Fossils (Helix Fossil, Dome Fossil, Old Amber, Root Fossil, Claw Fossil, Skull Fossil, Armor Fossil, Cover Fossil, Plume Fossil, Jaw Fossil, Sail Fossil)-28 Pokeball variations -27 Evolution Items -47 Mega Stones -1 Key Stone -50 Gym badges -2 «GHOST» Pokemon (original R / B / Y and FR / LG)-20 Beta Gen 1 Unused Pokemon (Dragon4, Poliwag beta, Nyosuka / Poliwhirl beta, Kokana / Weedle beta, Staryu beta, Blastoise beta, Lapras beta, Dragonair beta, Rokku / Rydon beta, Kasanagi and Kasanagi evolution unused beta Pokemon, Gengar beta, Nidorino beta, Godzillante, Gorillaimo, Buhi, Papyo, Koffing, Shellder, Cloyster)-11 Beta Gen 2 Unused Pokemon (Gonoguma, Kurusu, Happa, Unnamed turtle, unnamed creature, black skinned promo design Bellossom, Ladyba beta, marril beta, Baku / Quillfish beta, Girafarig beta, Raikou / Suicune beta)-7 Beta Gen 3 Unused Pokemon (Blaziken / Latias or «Latiken», Torchic beta 1, Torchic beta 2, Treecko beta, Groudon beta, Shellos beta, Gastrodon beta)-6 Glitch Pokemon (Missingno, Golden Bulbasaur,??????, Kabutops Fossil Form, Aerodactyl Fossil Form, Bag Egg)-1 Beta Gen 6 Pokemon (HooForm)-4 extra Flabebe variations -5 extra Floette variations -4 extra Florges variations -9 extra Furfrou variation -1 extra Aegislash variations -3 extra Pumpkaboo variations -3 extra Gourgeist variation -1 extra Xerneas variation -1 extra Hoopa variation -1 extra Haunter variation (Original sprite)-1 extra Koffing variation (upside down from R / B / G)-1 extra Ivysaur variation (Standing from R / B / G)-1 extra Golbat variation (Crazy giant mouth from R / B)-1 extra Munchlax variation (Flying)-1 extra Magearna color variation -2 Kyurem variations (Black Active and White Active forms)-1 Dragon Skeleton -1 extra Cloyster variation (old horizontal sprite)-1 extra Exeggcute variation (old R / B sprite)-1 extra Excadrill variation (Gen 5 beta with backwards body design)-1 additional Kingler variation (original double giant claw sprite)-3 Pokemon GO Eggs -11 Fossils (Helix Fossil, Dome Fossil, Old Amber, Root Fossil, Claw Fossil, Skull Fossil, Armor Fossil, Cover Fossil, Plume Fossil, Jaw Fossil, Sail Fossil)-28 Pokeball variations -27 Evolution Items -47 Mega Stones -1 Key Stone -50 Gym badges -2 «GHOST» Pokemon (original R / B / Y and FR / LG)-20 Beta Gen 1 Unused Pokemon (Dragon4, Poliwag beta, Nyosuka / Poliwhirl beta, Kokana / Weedle beta, Staryu beta, Blastoise beta, Lapras beta, Dragonair beta, Rokku / Rydon beta, Kasanagi and Kasanagi evolution unused beta Pokemon, Gengar beta, Nidorino beta, Godzillante, Gorillaimo, Buhi, Papyo, Koffing, Shellder, Cloyster)-11 Beta Gen 2 Unused Pokemon (Gonoguma, Kurusu, Happa, Unnamed turtle, unnamed creature, black skinned promo design Bellossom, Ladyba beta, marril beta, Baku / Quillfish beta, Girafarig beta, Raikou / Suicune beta)-7 Beta Gen 3 Unused Pokemon (Blaziken / Latias or «Latiken», Torchic beta 1, Torchic beta 2, Treecko beta, Groudon beta, Shellos beta, Gastrodon beta)-6 Glitch Pokemon (Missingno, Golden Bulbasaur,??????, Kabutops Fossil Form, Aerodactyl Fossil Form, Bag Egg)-1 Beta Gen 6 Pokemon (HooForm, Aerodactyl Fossil Form, Bag Egg)-1 Beta Gen 6 Pokemon (HooForm, Bag Egg)-1 Beta Gen 6 Pokemon (Hooded)

Over the past few years Amazon have been making their break in the games industry with the forming of their in house games development studio, the purchase of Double Helix Games and partnerships with studios such as WayForward and Human Head Studios.

The helix - type form that appears repeatedly throughout the banners and wall painting, serves as the logo, or tag, for SAP.

Most recently, her large - scale paintings and glass - and 3D - printed sculptures articulate the relationship between natural forms such as the wave, the vortex, and the helix, with planes of sight and human gesture.

The combination of the Fab - Form and Helix Micro-Rebar saved a considerable amount of labor and cost and resulted in a high quality and well insulated foundation / crawlspace.

This stair is in the Institute of Molecular Genetics for the Czech Academy of Science, and fittingly, is modeled after the form of the DNA double helix.

And Angela, interestingly for me, in describing her «spherical» understanding comes close to outlining the conception I have of a new form of text (and now I mean textbook) that, thanks to the marvels of IT, is constructed somewhat like a helix, allowing a learner to proceed between levels of sophistication as the need and interest arises.

Provided exploitation capability for various forms of digital and analog media using tools such as (EnCase, FTK Mobile Edit, Nokia PC Suit, Oxygen Phone Manager II, and Helix)