They were born without a working copy of CLN2, a gene whose protein
helps lysosomes — the cell's garbage - disposing structures — break down a waste product called lipofuscin.
Together, the three genes
help the lysosomes do their job.
Not exact matches
Working with Ana Maria Cuervo, a professor at Albert Einstein College of Medicine, Nixon and co-workers found that presenilin - 1
helps control the acidity of
lysosomes.
So the idea would be to identify the enzymes these organisms use to digest lysosomal wastes, modify them a bit to
help them work in the slightly different environment of the human
lysosome, and then deliver them to where they need to go in our cells.
Breast milk contains antibodies, immunoglobulins, white blood cells, lactoferrin,
lysosomes, bifidus factor (which
helps friendly bacteria grow in the intestines to ensure acid environment), vitamin B12 binding protein, and many, many other substances.