Sentences with phrase «hemagglutinin with»

Not exact matches

The appearance - changing coat of the influenza virus is studded with mainly two proteins: hemagglutinin, which allows the virus to attach to and enter a cell; and neuraminidase, which boosts the virus's ability to pass to other cells.

«Almost all of the animals that were vaccinated survived, including mice that were challenged with viruses that expressed hemagglutinin subtypes that were not in the vaccine at all, viruses that expressed H2, H6, H10, and H11,» said Dr. Taubenberger.

In cancer patients with weakened immune systems, changing certain amino acids in the flu virus's hemagglutinin protein (illustrated) made the virus better able to compete with other virus variants.

Animal models come with some uncertainty, cautions biochemist James Stevens of the Scripps Research Institute in La Jolla, Calif., but he says «it's probably the hemagglutinin switch which is going to be one of the critical events» in a future pandemic.

In their experimental treatment, he and his colleagues injected mice, ferrets, and monkeys with viral DNA, causing their muscle cells to produce hemagglutinin, a protein found on the surface of all flu viruses.

Like kids with a sweet tooth, the immune system gets most excited about the top part of the hemagglutinin lollipop, and makes antibodies against it.

After 2 doses of an H7N9 formulation containing 15 µg of hemagglutinin given without adjuvant, with AS03 adjuvant, or with MF59 adjuvant, the proportion achieving an hemagglutination inhibition antibody (HIA) titer of 40 or higher was 2 percent without adjuvant (n = 94), 84 percent with AS03 adjuvant (n = 96), and 57 percent with MF59 adjuvant (n = 92).

Researchers noticed that when people with swine flu developed antibodies to the virus, those antibodies did something odd: They favored the hemagglutinin stem — the stick of the lollipop.

Using a crystal structure of a complex protein compound of botulinum neurotoxin, Rongsheng Jin, associate professor of physiology & biophysics at UC Irvine, and collaborators found that these compounds — called clostridial hemagglutinin (HA)-- bind with epithelial cell proteins in the intestines of patients, which initiates a process that disrupts the close intercellular seals so that the complex toxin molecules can slip through the epithelial barrier.

Using virus histochemical analysis, the investigators looked at the pattern of attachment of two genetically engineered emerging H7 viruses (containing the hemagglutinin (HA) of either influenza virus A / Shanghai / 1 / 13 or A / Anhui / 1 / 13) to fixed human respiratory tract tissues and compared the findings to attachment patterns seen with human influenza viruses with high transmissibility but low virulence (seasonal H3N2 and pandemic H1N1) and highly pathogenic avian influenza (HPAI) viruses with low transmissibility and high virulence (H5N1 and H7N7).

Or an H5N1 virus that has infected a person could swap some of its eight genes with those of a human flu virus — keeping its hemagglutinin (HA) surface protein, to which people have no immunity.

Kawaoka and his team, whose work has been accepted by Nature, created a chimeric virus with the hemagglutinin protein from H5N1 and the genes from the 2009 pandemic strain of H1N1.

The method is much less cumbersome than dealing with chicken eggs, and because the vaccine is so easy to produce, the company intends to use 135 micrograms of hemagglutinin in each dose of vaccine — 3 times higher than current flu vaccines — in hopes of getting better protection.

Now, Skehel, along with colleagues at Harvard, Yale, and Emory University in Atlanta, Georgia, has used that sequence to build the virus's hemagglutinin (HA)-- a protein that latches onto receptors on the host cell surface — and determine its structure.

Like the combination therapies used to treat HIV, scientists could design a suite of slightly different proteins that targets the hemagglutinin stem region, making it more difficult for the virus to dodge the drug with a single mutation.

People with higher levels of antibodies against the stem portion of the influenza virus hemagglutinin (HA) protein have less viral shedding when they get the flu, but do not have fewer or less severe signs of illness, according to a new study published in mBio.

But Tompkins warns that repeated vaccinations with distinct hemagglutinins would probably be needed to protect birds from the many strains of avian influenza virus.

Insights into Avian Influenza Virus Pathogenicity: the Hemagglutinin Precursor HA0 of Subtype H16 Has an Alpha - Helix Structure in Its Cleavage Site with Inefficient HA1 / HA2 Cleavage

As an example, Harrison is trying to use EM to investigate interactions of human antibodies with the influenza hemagglutinin glycoprotein.

The expression vector contained the cDNAs coding for a potential fusion protein containing the GFP (EGFP), the 2A esterase of foot - and - mouth disease virus (FMDV), and HOXB4 with an additional N - terminal hemagglutinin (HA) epitope tag (eGFP2AHOXB4).

The influenza virus invades cells by puncturing the cell wall with the tiny spikes of hemaGglutinin that cover its surface.