Sentences with word «hematopoetic»

Using mice deficient in Del - 1, they found that the protein promotes proliferation and differentiation of hematopoetic stem cells, sending more of these progenitor cells down a path toward becoming myeloid cells, such as macrophages and neutrophils, rather than lymphocytes, such as T cells and B cells.

Indeed, inhibiting CXCR4 function systemically with the small molecule antagonist plerixafor results in the peripheral mobilization of hematopoetic stem cells, thus mitigating the potential of such therapy for long - term anti-retroviral therapy.

The safe and effective delivery of genetically modified hematopoetic stem cells represents biological innovation by demonstrating that genetic modification of cells in the myeloid compartment has a profound impact upon the brain.

«It will be worthwhile to study its expression in the context of hematopoetic malignancy.»

The researchers» investigations revealed that Del - 1 was expressed by at least three cell types in the bone marrow that support hematopoetic stem cells: endothelial cells, CAR cells and osteoblasts.

Bone marrow contains hematopoetic stem cells, the precursors to every blood cell type.

Hajishengallis, Chavakis and their colleagues identified the protein on hematopoetic stem cells with which Del - 1 interacts, the ß3 integrin, perhaps pointing to a target for therapeutic interventions down the line.

To test this, the team took mouse hematopoetic progenitor cells — cells that give rise to white blood cells — and modified them to overexpress a protein called Id3.

Many of the reports received have involved serious, life - threatening adverse events, such as anaphylaxis, convulsions, hematopoetic disorders, and hepatopathies, followed in some cases by death.

In donors, blocking the interaction between Del - 1 and hematopoetic stem cells could enhance the mobilization of those progenitors into the bloodstream.

I couldn't resist composing this after the mention of the charmingly misspelled word «hematopoetic» in your story on blood grown in the lab from stem cells (12 November, p 8):

I couldn't resist composing this after the mention of the charmingly misspelled word «hematopoetic» in your story on blood grown...

«I think that Del - 1 represents a major regulator of the hematopoetic stem cell niche,» said Triantafyllos Chavakis, co-senior author on the study and a professor at the Technical University of Dresden.

«Because the hematopoetic stem cell niche is so important for the creation of bone marrow and blood cells and because Del - 1 is a soluble protein and is easily manipulated, one can see that it could be a target in many potential applications,» said George Hajishengallis, the Thomas W. Evans Centennial Professor in the Department of Microbiology in Penn's School of Dental Medicine and a senior author on the work.

In January 2015, Intellia announced a five - year research and development collaboration with Novartis to accelerate the ex vivo development of new CRISPR - Cas9 - based therapies using chimeric antigen receptor T cells (CARTs) and hematopoetic stem cells (HSCs).

Bone marrow transplantation (hematopoetic stem cell transplantation) can also be considered immunotherapy because the donor's immune cells will often attack the tumor or cancer cells that are present in the host.

Hematopoetic stem cell mobilization in patients with non-Hodgkin's lymphoma and multiple myeloma

Hematopoetic stem cell mobilization in patients with Leukemia, Lymphoma and Multiple Myeloma

The study thereby sheds light on the cross talk between the brain and the hematopoetic system, pointing to biological innovation arising from interdisciplinary collaborations.

By presenting a safe and effective delivery method of genetically modified hematopoetic stem cells, the study has improved our understanding of ALD and the cross-talk between the brain and the hematopoetic system.