Not exact matches
In our laboratory, we have previously described an in vitro model of spontaneous transformation of the IL -3-dependent
hematopoietic BaF3
cell line towards growth factor - independent tumorigenic clones with constitutive STAT5
activation.14 This model was developed from the study of BaF3
cells transfected with an IL - 9Rα mutant lacking the STAT - recruiting site (BaF3 phe116).
IL - 6 has been shown to be involved in diverse physiological processes such as T -
cell activation, induction of immunoglobulin secretion, initiation of hepatic acute phase protein synthesis, and stimulation of
hematopoietic precursor
cell proliferation and differentiation.
Because Syk is expressed in many kinds of
hematopoietic lineage
cells and involved in various ITAM - mediated signal transduction pathways (45), our current finding that RhoH facilitates Syk
activation will shed new light on ITAM - based immune responses.