There are no specific markers to identify them; however, they are negative for
hematopoietic cell markers like CD34 / 45 / HLA - DR and express CD90 / 73/105 on their surface 2, 3, 4.
Not exact matches
When Busch turned on the
marker in adult animals, it became visible that at least one third (approximately 5000
cells) of a mouse's
hematopoietic stem
cells produce differentiated progenitor
cells.
Nearly 30 years after the discovery of the
hematopoietic stem
cell, Stanford researchers have found a
marker that allows them to study the version of these stem
cells that continues to replicate.
This gave a mixed population of
cells with 20 % expressing CD34, a
hematopoietic stem
cell marker, with some co-expression of endothelial
cell markers (CD31, Flk1, and VE - cadherin).
Hematopoietic stem
cells express the
markers CD34 and CD133 and can repopulate a myeloablated recipient after allogeneic or autologous transplantation.
Here, ES
cells transduced with HOXB4 were analyzed for the expression of
hematopoietic markers after 26 days of differentiation.
Importantly, these
cells expressed CD45, with smaller subpopulations expressing the important
hematopoietic markers CD117 and Sca - 1, suggesting that these
cells may have the potential to populate bone marrow and eventually replenish senescent peripheral blood
hematopoietic cells.
Finally, within the fractionated
cell populations, there was evidence for coexpression of lineage specific
markers alongside of pluripotency genes, similar to lineage priming described first in
hematopoietic stem
cells [15].