Sentences with phrase «hematopoietic cells in bone marrow»

Not exact matches

«Proper blood cell production is dependent on functioning hematopoietic stem and progenitor cells that are destroyed during conditioning procedures for transplantation or following bone marrow injury,» said the study's first author Kevin A. Goncalves, who performed this research as part of his PhD studies in cellular and molecular physiology at the Sackler School.

In addition to suppressing the mature blood cells battling against the infection, malfunctioning of this signaling system results in permanent damage to the body's blood producing cells — called hematopoietic stem cells — that are located in the bone marroIn addition to suppressing the mature blood cells battling against the infection, malfunctioning of this signaling system results in permanent damage to the body's blood producing cells — called hematopoietic stem cells — that are located in the bone marroin permanent damage to the body's blood producing cells — called hematopoietic stem cells — that are located in the bone marroin the bone marrow.

Hematopoietic stem cells — bone marrow - derived adult stem cells that give rise to the wide variety of specialized blood cells — come in two flavors: the reserve force sits quietly waiting to be called upon while the active arm continually proliferates spawning billions of blood cells every day.

To gauge the effect off the loss of imprinting control on the maintenance of the quiescent hematopoietic stem cell pool, Venkatraman analyzed the numbers of quiescent, active and differentiated hematopoietic stem cells in mouse bone marrow.

Our blood is generated by blood - forming (hematopoietic) stem cells (HSCs) in the bone marrow.

These so - called hematopoietic stem cells (from Greek meaning «to make blood») have been reliably used over the past 40 years to seed bone marrow transplants in the treatment of some cancers and immune disorders.

In fact, hematopoietic stem cells differentiate to generate megakaryocytes in bone marroIn fact, hematopoietic stem cells differentiate to generate megakaryocytes in bone marroin bone marrow.

Employing the advanced technology of the Institute's Cytometry, Imaging and Histology centers, the researchers examined the relationship between megakaryocytes and hematopoietic stem cells in mouse bone marrow.

In the study, USC Stem Cell researcher Casey Brewer and colleagues in the laboratory of Rong Lu found that transplantation dose affects the behavior of blood - forming stem cells in bone marrow — called hematopoietic stem cells, or HSCIn the study, USC Stem Cell researcher Casey Brewer and colleagues in the laboratory of Rong Lu found that transplantation dose affects the behavior of blood - forming stem cells in bone marrow — called hematopoietic stem cells, or HSCin the laboratory of Rong Lu found that transplantation dose affects the behavior of blood - forming stem cells in bone marrow — called hematopoietic stem cells, or HSCin bone marrow — called hematopoietic stem cells, or HSCs.

«We found that TRAF6 overexpression in mouse hematopoietic stem cells results in impaired blood cell formation and bone marrow failure,» said Starczynowski, a member of the Division of Experimental Hematology and Cancer Biology at Cincinnati Children's Hospital Medical Center.

Leukemia starts in the «hematopoietic» stem cells in the bone marrow that give rise to all the different kinds of mature blood cells.

Beilhack and colleagues found that a slightly modified version of STAR2 has a similar effect on human T reg cells, suggesting that the approach could also prevent GvHD in leukemia and lymphoma patients after bone marrow or hematopoietic stem cell transplants.

Tie2 / angiopoietin -1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche.

Furthermore, these potentials are expanded by the notion that MSCs can exert functions other than those classically attributed to stem or progenitor cells, including establishment and support of the hematopoietic microenvironment in vivo, as observed for bone marrow derived MSCs.

Human immunodeficiency virus (HIV) can infect bone marrow cells — including, possibly, hematopoietic stem cells, according to a study published online today (March 7) in Nature Medicine.

Cytokinesis failure occurs in Fanconi anemia pathway — deficient murine and human bone marrow hematopoietic cells.

Furthermore, stem cells in bone marrow may form not just hematopoietic cells, but cardiac muscle cells, neural cells, and other types of cells; this is an example of stem - cell plasticity.

This new knowledge has paved the way for the therapeutic transfer of stem cells not only for the treatment of hematopoietic diseases by bone marrow transplantation â $» first attempted by E. Donnall Thomas, one of this bookâ $ ™ s editors, in 1957 â $» but also for the treatment of many other disorders.

Bone marrow CD169 + macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche.

Platelets (or thrombocytes) control the process of blood clotting and transfusions are common to prevent bleeding in treatments involving hematopoietic stem cell (HSC) and bone marrow (BM) transplantation [1].

The chemotherapy is designed to make space in the bone marrow for the gene - corrected hematopoietic stem cells to settle in and start working.

The Hematopoietic stem cell population resident in bone marrow is responsible for generating blood cells and immune cells.

Added to this is the fact that white fat also damages the hematopoietic stem cells of bone marrow which could results in reduced blood cell formation in bone with excess fatty infiltration.

In her project, Sipkins will investigate molecular characteristics of tissue microenvironments, or «niches,» within the bone marrow and how normal, healthy hematopoietic stem cells, which give rise to the many kinds of blood cells, compete with malignant cells to occupy these coveted niches.

A quantitative assessment of the content of hematopoietic stem cells in mouse and human endosteal - bone marrow: a simple and rapid method for the isolation of mouse central bone marrow.

For example, we have no information about how these newly - generated HPCs will compete with autologous bone marrow cells for hematopoietic niches in the recipient mice.

We also analyzed the hematopoietic stem cells and various progenitor cells in the bone marrow.

Myelosuppression is a well - established side effect of current AML therapies, with prolonged events leading to an increased risk of infections and death.44 Consequently, therapies that preferentially kill leukemic cells over normal bone marrow cells are urgently required, and the overexpression of CD123 on AML leukemic stem cells and blasts compared with normal hematopoietic cells contributes to its attractiveness as a therapeutic target in this disease.6, 45 However, severe myelosuppression and myeloablation have emerged for some investigational CD123 - targeted treatment modalities.

Red marrow in the long bones is the pool from which hematopoietic stem cells originate.