The Workshop on Inherited
Hematopoietic Malignancies will discuss the scientific advances in understanding the pathogenesis of cancer development in individuals and families with germline mutations and predisposition to bone marrow derived malignancies.
Table 1 details the results of genotypic analysis for the JAK2V617F allele in 607 patients with
hematopoietic malignancies.
The identification of a single disease allele in 3 related myeloid diseases suggests that the JAK2V617F mutation may be important in the pathogenesis of additional
hematopoietic malignancies.
It is well known that HDAC inhibitors are potent anticancer drugs in
hematopoietic malignancies, including lymphoma.19 — 21 The aim of using HDAC inhibitors is to restore normal histone modification patterns through inhibition of various components of the epigenetic machinery.22, 23 In B - cell lymphoma, HDAC inhibitors can rescue deficits in histone acetylation induced by EP300 / CREBBP mutations, 24 rendering tumor cells more sensitive to suberoylanilide hydroxamic acid.25 This can explain why chidamide also has favorable efficacy on PTCL - NOS patients bearing EP300 / CREBBP mutations.
Silencing mTOR expression using siRNA has not been studied previously in
hematopoietic malignancies.
Hematopoietic malignancies were diagnosed using the following markers: for B - and T - lymphocyte detection, rat antimouse CD45R / B220 mAb (Southern Biotechnology Associates, Birmingham, AL; dilution 1:100); for T - lymphocyte detection, rabbit antihuman CD3 polyclonal antibody (Dako, Glostrup, Denmark; 1:100); and for monocyte / macrophage detection, rat antimouse F4 / 80 mAb (BMA Biomedicals AG, Augst, Switzerland; 1:20) and rat antimouse CD11b mAb (Chemicon International, Temecula, CA; 1:20).
Christopher N. Hahn, PhD SA Pathology Adelaide, SA, Australia Surprises in «Solving» Families with Predisposition to
Hematopoietic Malignancy
Not exact matches
The meeting focuses on basic and translational research and offers a unique occasion to exchange ideas on genetics of hematological
malignancies,
hematopoietic stem cells, genome editing and immunotherapy.
Mehta J, Gordon LI, Tallman MS, et al., Does younger donor age affect the outcome of reduced - intensity allogeneic
hematopoietic stem cell transplantation for hematologic
malignancies beneficially?
Use of a lower dose of rabbit anti — T - lymphocyte globulin (ATLG) was superior to a higher dose in children with hematologic
malignancies undergoing allogeneic
hematopoietic stem cell transplantation (HSCT) from an unrelated donor, according to the results of a study published in Lancet Oncology.
Accelerated aging of immune system after
hematopoietic stem cell transplantation Researchers demonstrated that
hematopoietic stem cell transplantation in patients with hematological
malignancies significantly accelerates aging of immune system.
Title: Polycomb group proteins in
hematopoietic stem cell aging and
malignancies Authors: Klauke K, de Haan G Date: 2011 Publication Details: International Journal of Hematology 2011 Jul; 94 (1): 11 - 23
Low - Dose ATLG Prevents GVHD in Pediatric Hematologic
Malignancies: A newly published randomized phase III study of pediatric patients showed lower doses of rabbit anti — T - lymphocyte globulin (ATLG) was superior to a higher dose in children with hematologic malignancies undergoing allogeneic hematopoietic stem cell transplantation from an unre
Malignancies: A newly published randomized phase III study of pediatric patients showed lower doses of rabbit anti — T - lymphocyte globulin (ATLG) was superior to a higher dose in children with hematologic
malignancies undergoing allogeneic hematopoietic stem cell transplantation from an unre
malignancies undergoing allogeneic
hematopoietic stem cell transplantation from an unrelated donor.
Activating mutations in tyrosine kinases have been identified in
hematopoietic and nonhematopoietic
malignancies.
Allogeneic cells, particularly mismatched or haploidentical cells, in the context of
hematopoietic transplantation have been found to provide potent immune surveillance for both hematologic and solid tumor
malignancies in a process referred to as graft - versus - tumor [13]--[15].