Sentences with phrase «hematopoietic progenitor»

Here, we show that AZA responders have more hematopoietic progenitor cells (HPCs) in the cell cycle.

Alternatively, embryonic stem (ES) cells have emerged as a potential source of less immunogenic hematopoietic progenitor cells (HPCs).

Arndt K, Grinenko T, Mende N, Reichert D, Portz M, Ripich T, Carmeliet P, Corbeil D, Waskow C. CD133 is a modifier of hematopoietic progenitor frequencies but is dispensable for the maintenance of mouse hematopoietic stem cells.

The FDA has approved the use of stem cell - based products, including cord blood - derived hematopoietic progenitor cells (blood forming stem cells) for many diseases.

The FLT3 - signaling pathway controls cell proliferation and survival, particularly of hematopoietic progenitor cells.

A detailed comparison of gene expression signatures between ETP ALL tumors and and normal human hematopoietic progenitor cells revealed a somewhat surprising finding: ETP - ALL expression patterns were less consistent with early T - cell precursors, as might have been expected, but more similar to the expression profile of normal hematopoietic stem cells and granulocyte macrophage precursors.

It's blood in a newborn baby's umbilical cord that's rich in a type of stem cell called hematopoietic progenitor cells (HPCs).

Ana Fonseca (Corbeil, TUD)-- «New insights into cell migration and asymmetric cell division of human hematopoietic progenitors» (2008)

The chemokine receptor CXCR - 4 is expressed on CD34 + hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell - derived factor - 1.

New insights into the cell biology of hematopoietic progenitors by studying prominin - 1 (CD133).

Additional in vitro and in vivo studies are needed to determine the cause of the specificity of JAK2V617F for myeloid diseases, as second mutations, host modifiers, differential cytokine receptor expression, and other factors may influence the ultimate phenotype of hematopoietic progenitors that acquire the JAK2V617F mutation.

This observation suggests that activation of the JAK - STAT pathway and the RAS — mitogen - activated protein kinase (MAPK) pathway can cooperate in CMML, and suggests that the possibility that additional mutations in JAK2V617F mutant hematopoietic progenitors may direct the eventual disease phenotype in specific patients.

Not exact matches

Researchers at University of California San Diego School of Medicine report that a single infusion of wildtype hematopoietic stem and progenitor cells (HSPCs) into a mouse model of Friedreich's ataxia (FA) measurably halted cellular damage caused by the degenerative disease.

Human hematopoietic stem and progenitor cells (HSPCs), derived from bone marrow, have become a primary vehicle for efforts to replace or regenerate cells destroyed by a variety of diseases.

When Busch turned on the marker in adult animals, it became visible that at least one third (approximately 5000 cells) of a mouse's hematopoietic stem cells produce differentiated progenitor cells.

«Proper blood cell production is dependent on functioning hematopoietic stem and progenitor cells that are destroyed during conditioning procedures for transplantation or following bone marrow injury,» said the study's first author Kevin A. Goncalves, who performed this research as part of his PhD studies in cellular and molecular physiology at the Sackler School.

The findings were published in an article, «Angiogenin promotes hematopoietic regeneration by dichotomously regulating quiescence of stem and progenitor cells,» in the August 11, 2016 issue of the journal Cell.

She then followed up with a closer look at role of the Igf2 signaling pathway in coaxing quiescent hematopoietic stem cells to start dividing and maturing into multi-lineage progenitors that ultimately give rise to specialized blood cells.

Through gene therapy, researchers engineered blood - forming stem cells (hematopoietic stem / progenitor cells, or HSPCs) to carry chimeric antigen receptor (CAR) genes to make cells that can detect and destroy HIV - infected cells.

Earlier mouse studies by Li and his collaborators had indicated that the expression of several imprinted genes changes as hematopoietic stem cells embark on their journey from quiescent reserve cells to multi-lineage progenitor cells, which form the many highly specialized cell types that circulate within the blood stream.

Although many immunosuppressive strategies have failed, the recent use of autologous hematopoietic stem and progenitor cell (HSPC) transplantation has shown therapeutic promise.

Furthermore, these potentials are expanded by the notion that MSCs can exert functions other than those classically attributed to stem or progenitor cells, including establishment and support of the hematopoietic microenvironment in vivo, as observed for bone marrow derived MSCs.

Expression of the melanoma cell adhesion molecule in human mesenchymal stromal cells regulates proliferation, differentiation, and maintenance of hematopoietic stem and progenitor cells.

Recent evidence suggests the existence of progenitor cells in adult tissues that are capable of differentiating into vascular structures as well as into all hematopoietic cell lineages.

Bone marrow CD169 + macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche.

Regina Duryagina (Bornhäuser, TUD)-- «Role of Jagged - 1 and extracellular matrix components for the maintenance of hematopoietic stem and progenitor cells during ex-vivo expansion» (2013)

Immune cells are descendants of bone marrow - resident hematopoietic stem cells (HSC) and are regenerated throughout life, thus, they have the unique capability to continuously regenerate but also to give rise to non-self renewing multipotent progenitor cells.

Review of «Evaluating Interaction of Cord Blood Hematopoietic Stem Progenitor Cells with Functionally Integrated 3D microenvironments» from STEM CELLS Translational Medicine by Stuart P. Atkinson

While human cord blood represents a potentially important source of hematopoietic stem and progenitor cells (HSPC), current two dimensional (2D) growth conditions employed to amplify cell numbers to the level required for many regenerative applications lead to a decline in the absolute percentage of the most primitive HSPCs [1].

Recent papers published by groups from UC Berkeley and Stanford University have described methods for the genetic manipulation of primary human hematopoietic stem and progenitor cells (HSPCs) that require them to be maintained in vitro for anywhere from 24 hours to more than a week.

Review of «Safety and efficacy of a tCD25 pre-selective combination anti-HIV lentiviral vector in human hematopoietic stem and progenitor cells» from Stem Cells by Stuart P. Atkinson

HIV gene therapy hopes to confer HIV ‐ resistance to patients through the genetic manipulation of hematopoietic stem / progenitor cells (HSPCs)[1, 2].

Selection - free genome editing of the sickle mutation in human adult hematopoietic stem / progenitor cells.

Allogeneic cell therapies involving primary cell types such as bone marrow mesenchymal stromal / stem cells (BM - MSCs), hematopoietic stem and progenitor cells (HSPCs), and T and natural killer (NK) cells for immunotherapy applications are especially challenging because of the vigorous process of screening...

Title: The combination of valproic acid and lithium delays hematopoietic stem / progenitor cell differentiation Authors: Walasek MA, Bystrykh LV, van den Boom V, Olthof S, Ausema A, Ritsema M, Huls G, de Haan G and van Os R Date: 2012 Publication Details: Blood 2012 Mar 29; 119 (13): 3050 - 59

Functional rescue of dopaminergic neuron loss in Parkinson's disease mice after transplantation of hematopoietic stem and progenitor cells, EBioMedicine, in press.

In this work, we transplanted hematopoietic stem and progenitor cells into the substantia nigra of brains of two different mouse models of Parkinson's disease.

By transplanting Wnt - activated hematopoietic stem and progenitor cells (HSPCs) we demonstrated that Muller cells can be reprogrammed in vivo after fusion with HSPCs.

Zonari E, Desantis G, Petrillo C, Boccalatte FE, Lidonnici MR, Kajaste - Rudnitski A, Aiuti A, Ferrari G, Naldini L, Gentner B. Efficient ex vivo engineering and expansion of highly purified human hematopoietic stem and progenitor cell populations for gene therapy.

Dual actions of Meis1 inhibit erythroid progenitor development and sustain general hematopoietic cell proliferation.

Functional rescue of dopaminergic neuron loss in Parkinson's disease mice after transplantation of hematopoietic stem and progenitor cells.

We also analyzed the hematopoietic stem cells and various progenitor cells in the bone marrow.

Umbilical cord blood has a number of different types of cord stem cells, like endothelial progenitor cells, hematopoietic stem cells, and mesenchymal stem cells.