Sentences with phrase «hematopoietic stem cell»

New Insights on Pain and Opioid Use in People With Sickle Cell Disease After Hematopoietic Stem Cell Transplant (March 12, 2018)

One type of stem cell transplant, autologous hematopoietic stem cell transplantation, uses stems cells from your own bone marrow, or from external umbilical cord blood.

Michael Gustave Poulos, PhD Weill Cornell Medical College New York, NY Aging Vascular Endothelium Modulate Hematopoietic Stem Cell Activity

Marie - Dominique Filippi, PhD, PhD Cincinnati Children's Hospital Medical Center Cincinnati, OH Mitochondrial Morphology Controls Hematopoietic Stem Cell Self - Renewal and Confers Them Divisional Memory

The workshop will focus on topics such as; hematopoietic stem cell biology, leukemogenesis, cell signaling, transcription factors, epigenetic effects, and other topics related to myeloid biology.

Aging of the hematopoietic stem cell (HSC) compartment is characterized by lineage bias and reduced stem cell function, the molecular basis of which is largely unknown.

«We are actively involved in expanding the possible resources for hematopoietic stem cell transplantation for these patients.»

Sf3b1 ^{K700E / +} animals had impaired erythropoiesis and progressive anemia without ringed sideroblasts, as well as reduced hematopoietic stem cell numbers and host - repopulating fitness.

Cuvelier GD, Schultz KR, Davis J, Hirschfeld AF, Junker AK, Tan R, Turvey SE.: Optimizing outcomes of hematopoietic stem cell transplantation for severe combined immunodeficiency.

But until gene therapy is more commonplace, the only curative treatment for sickle cell is hematopoietic stem cell transplantation.

Compared with the toxicity that we see with allogeneic donor hematopoietic stem cell therapy, these toxicities are relatively manageable with close monitoring and close supportive care.

Telomere dysfunction induces environmental defects limiting hematopoietic stem cell function and engraftment.

These allogeneic cells have the potential to participate in immune surveillance for breast or other cancers as observed in clinical hematopoietic stem cell transplantation.

«I also see hematopoietic stem cell transplantation, which is a primary concern at City of Hope, becoming a less - toxic treatment with similar or better long - term effects,» Rosenthal added.

Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment.

Singh, R. P., Franke K., Kalucka J., Mamlouk S., Muschter A., Gembarska A., Grinenko T., Willam C., Naumann R., Anastassiadis K., Stewart A. F., Bornstein S., Chavakis T., Breier G., Waskow C., and Wielockx B. HIF - prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady - state and stress.

Low - Dose ATLG Prevents GVHD in Pediatric Hematologic Malignancies: A newly published randomized phase III study of pediatric patients showed lower doses of rabbit anti — T - lymphocyte globulin (ATLG) was superior to a higher dose in children with hematologic malignancies undergoing allogeneic hematopoietic stem cell transplantation from an unrelated donor.

Douglas Taylor, M.D. (Director, Pediatric Hematopoietic Stem Cell Transplantation, Univ California, Davis)

A number of treatments exist, including enzyme replacement therapy and hematopoietic stem cell transplantation, but efficacy depends upon diagnosing the disease and its specific form as early as possible.

The patients» biopsies she sees are mainly from child recipients of oncologic and hematopoietic stem cell transplants.

Understanding of leukemias also could be aided by insight into the hematopoietic stem cell regulatory circuitry, said Singh.

Gentner B, Visigalli I, Hiramatsu H, Lechman E, Ungari S, Giustacchini A, Schira G, Amendola M, Quattrini A, Martino S, Orlacchio A, Dick JE, Biffi A, Naldini L. Identification of hematopoietic stem cell - specific miRNAs enables gene therapy of globoid cell leukodystrophy.

Guido Silvestri, MD, division chief of Microbiology and Immunology at the Yerkes Research Center at Emory, and several of his research colleagues performed the first hematopoietic stem cell transplantation in three rhesus macaques infected with a simian human immunodeficiency virus (SHIV).

Stem Cell Biologist My area of expertise is in basic hematopoietic stem cell (HSC) biology and malignant hematologic diseases, especially Myelodysplastic Syndrome (MDS).

The Treatment: Autologous hematopoietic stem cell transplantation (AHSCT) is an aggressive procedure which involves collecting stem cells from an...

When undergoing treatment for leukemia many patients require hematopoietic stem cell (HSC) transplantation to replace the blood stem... Continue reading Mice pave the way to a cord blood transplant advance

The role of conditioning in hematopoietic stem cell gene therapy.

The Hematopoietic stem cell population resident in bone marrow is responsible for generating blood cells and immune cells.

Studies to improve the knowledge of genetic diseases include the natural history study for MLD, advanced diagnosis and natural history of primary immunodeficiencies and immunedysregulatory disorder, and immune reconstitution after hematopoietic stem cell transplantation for genetic disorders.

Warren D. Shlomchik, M.D. Yale University Memory T cells for improved immune reconstitution and GVL in allogeneic hematopoietic stem cell transplantation

Title: Polycomb group proteins in hematopoietic stem cell aging and malignancies Authors: Klauke K, de Haan G Date: 2011 Publication Details: International Journal of Hematology 2011 Jul; 94 (1): 11 - 23

Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiency.

Title: Estimating dormant and active hematopoietic stem cell kinetics through extensive modeling of bromodeoxyuridine label - retaining cell dynamics Authors: van der Wath RC, Wilson A, Laurenti E, Trumpp A, Liò P Date: 2009 Publication Details: PLoS One.

Clinical experiences for the nurse practitioner fellow include rotations on the leukemia, lymphoma, solid tumor, neuro - oncology, late effects, hematology, the inpatient general hematology / oncology unit, hematopoietic stem cell transplant unit, and palliative care.

Accelerated aging of immune system after hematopoietic stem cell transplantation Researchers demonstrated that hematopoietic stem cell transplantation in patients with hematological malignancies significantly accelerates aging of immune system.

Proliferation Drives Aging - Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

Use of a lower dose of rabbit anti — T - lymphocyte globulin (ATLG) was superior to a higher dose in children with hematologic malignancies undergoing allogeneic hematopoietic stem cell transplantation (HSCT) from an unrelated donor, according to the results of a study published in Lancet Oncology.

Hematopoietic stem cell transplantation without irradiation.

The role of hematopoietic stem cell transplantation in treatment of hemophagocytic lymphohistiocytosis.

Before coming to Columbia she worked as a technician in Leonard Zon's lab at Harvard Medical School using zebrafish as a model for investigating the molecular mechanisms of hematopoietic stem cell differentiation and self renewal.

Title: Hematopoietic Stem Cell Function and Survival Depend on c - Myc and N - Myc Activity Authors: Laurenti E, Varnum - Finney B, Wilson A, Ferrero I, Blanco - Bose WE, Ehninger A, Knoepfler PS, Cheng PF, MacDonald HR, Eisenman RN, Bernstein ID, Trumpp A Date: 2008 Publication Details: Cell Stem Cell, Volume 3, Issue 6, 611 - 624, 4 December 2008

Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self - renewal.

Another modified peptide POL6326 is in phase II clinical trial in hematopoietic stem cell mobilization in multiple myeloma [128].

Plerixafor in combination with granulocyte - colony stimulating factor (G - CSF) has been approved for hematopoietic stem cell mobilization to the peripheral blood in patients with non-Hodgkin's lymphoma and multiple myeloma [54].

One promising solution to increase long - term overall survival has been in the area of allogeneic hematopoietic stem cell transplantation (HCST).

Platelets (or thrombocytes) control the process of blood clotting and transfusions are common to prevent bleeding in treatments involving hematopoietic stem cell (HSC) and bone marrow (BM) transplantation [1].

Hematopoiesis, where a single hematopoietic stem cell gives rise to the entire blood system, is an important model for differentiation with great medical importance.

Hematopoietic stem cell transplantation was also more common in patients treated with inotuzumab ozogamicin (48 % vs 22 %).

Basically what was happening when you use a hematopoietic stem cell to correct an inherited metabolic disease is that through engraftment of that cell you are allowing that cell to become the replacement source for the missing enzyme or other factor - almost like a cellular form of gene therapy or, as I call it, «poor man's gene therapy».

The hematopoietic stem cell polarization and migration: A dynamic link between RhoA signaling pathway, microtubule network and ganglioside - based membrane microdomains.