Results from a phase 2 clinical trial, presented by Seattle Children's Research Institute at the 59th American Society of Hematology (ASH) Annual Meeting, show that the drug Abatacept (Orencia) nearly eliminated life - threatening severe acute graft - versus - host disease (GvHD) in patients
receiving hematopoietic stem cell transplants.
While some previous studies found that maintenance lenalidomide after
autologous hematopoietic stem cell transplant improved overall survival for newly diagnosed multiple myeloma patients, others showed no benefit to this approach.
Tens of thousands of these procedures, often referred to as bone marrow transplants but more properly
called hematopoietic stem cell transplants, are performed each year to rescue patients with immune system disorders or cancers.
Clinical experiences for the nurse practitioner fellow include rotations on the leukemia, lymphoma, solid tumor, neuro - oncology, late effects, hematology, the inpatient general hematology / oncology unit,
hematopoietic stem cell transplant unit, and palliative care.
Despite promising results from animal studies, the viability of the cell transplantation paradigm in human has been demonstrated in only a few contexts, mainly involving the use
of hematopoietic stem cell transplants, autologous skin and cartilage grafts, or the autologous recellularization of decellularized or engineered tissue.
Researchers at Dana - Farber / Boston Children's Cancer and Blood Disorders Center report promising outcomes from a clinical trial with patients with a rare form of bone marrow failure who received
a hematopoietic stem cell transplant (HSCT) after pre-treatment with immunosuppressive drugs only.
Patients who receive
a hematopoietic stem cell transplant are at risk of developing potentially lethal viral infections.
Omer, Tzannou and their colleagues conducted a clinical trial to determine the safety and effectiveness of pre-prepared virus - specific cells to treat five viral infections simultaneously in patients who had received
a hematopoietic stem cells transplant.
Beilhack and colleagues found that a slightly modified version of STAR2 has a similar effect on human T reg cells, suggesting that the approach could also prevent GvHD in leukemia and lymphoma patients after bone marrow or
hematopoietic stem cell transplants.
The software, developed in collaboration with Dr. Don Kristt, can be used to monitor chimerism level in both allogeneic stem cells transplant (SCT) or
hematopoietic stem cells transplant (HSCT), bone marrow transplant (BMT, post bone marrow engraftment), and cord and peripheral blood stem cells transplant (PBSCT) samples.
Some leukemia patients may require
a hematopoietic stem cell transplant (HSCT) to fully eradicate their disease.
The patients» biopsies she sees are mainly from child recipients of oncologic and
hematopoietic stem cell transplants.
The experience of caregivers of hematological cancer patients undergoing
a hematopoietic stem cell transplant: a comprehensive literature review.