«We are actively involved in expanding the possible resources for
hematopoietic stem cell transplantation for these patients.»
Cuvelier GD, Schultz KR, Davis J, Hirschfeld AF, Junker AK, Tan R, Turvey SE.: Optimizing outcomes of
hematopoietic stem cell transplantation for severe combined immunodeficiency.
Studies to improve the knowledge of genetic diseases include the natural history study for MLD, advanced diagnosis and natural history of primary immunodeficiencies and immunedysregulatory disorder, and immune reconstitution after
hematopoietic stem cell transplantation for genetic disorders.
Mehta J, Gordon LI, Tallman MS, et al., Does younger donor age affect the outcome of reduced - intensity allogeneic
hematopoietic stem cell transplantation for hematologic malignancies beneficially?
Not exact matches
UTSW co-authors include: Co-lead author Maria Winter, a research associate; Dr. Luisella Spiga, a postdoctoral researcher; visiting fellow Lisa Büttner; graduate students Elizabeth Hughes and Caroline Gillis, all of Microbiology; Dr. Breck Duerkop, Instructor, Immunology; Cassie Behrendt, a research technician, Immunology; Dr. Lora Hooper, Professor and Chair of Immunology with appointments in Microbiology and in the Center
for the Genetics of Host Defense, a HHMI Investigator and holder of the Jonathan W. Uhr, M.D. Distinguished Chair in Immunology, and the Nancy Cain and Jeffrey A. Marcus Scholar in Medical Research, in Honor of Dr. Bill S. Vowell; Dr. Luis Sifuentes - Dominguez, Instructor of Pediatrics; Dr. Kayci Huff - Hardy, clinical fellow, Internal Medicine in the Division of Digestive and Liver Diseases; Dr. Andrew Koh, Associate Professor of Pediatrics and Microbiology and in the Harold C. Simmons Comprehensive Cancer Center as well as Director of Pediatric
Hematopoietic Stem Cell Transplantation at Children's Health; and Dr. Ezra Burstein, Professor of Internal Medicine and Molecular Biology and Chief of the Division of Digestive and Liver Diseases.
«Proper blood
cell production is dependent on functioning
hematopoietic stem and progenitor
cells that are destroyed during conditioning procedures
for transplantation or following bone marrow injury,» said the study's first author Kevin A. Goncalves, who performed this research as part of his PhD studies in cellular and molecular physiology at the Sackler School.
Autologous
hematopoietic stem cell transplantation (AHSCT) has been investigated as a treatment
for aggressive MS, the rationale
for which is immune reconstitution.
Hematopoietic stem cell transplantation (HSCT), once considered an effective yet risky alternative to drug therapy
for blood cancer, has become more accessible and successful in a wide range of patients as a result of major advances in transplant strategies and technologies.
Zhao and his colleagues are also investigating whether a megakaryocyte niche can be used to help expand human
hematopoietic stem cells in vitro and
stem cell transplantation for patients.
Hematopoietic stem cell transplantation (HSCT) is a therapeutic option
for many patients with bone marrow failure.
It would have been more appropriate to note that their review targeted
hematopoietic stem cell transplantation because embryonic
stem cells are not yet ready
for clinical use.
As a result, they are currently being investigated as a cellular therapeutic
for the treatment of autoimmune diseases and long - term patient and graft survival following solid organ
transplantation, and allogeneic
hematopoietic stem cell transplantation.
Plerixafor has been approved by the FDA as the first small - molecule CXCR4 antagonist
for use in combination with granulocyte - colony stimulating factor (GCSF) to mobilize
hematopoietic stem cells to the bloodstream
for collection and subsequent autologous
transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma.
This new knowledge has paved the way
for the therapeutic transfer of
stem cells not only
for the treatment of
hematopoietic diseases by bone marrow
transplantation â $» first attempted by E. Donnall Thomas, one of this bookâ $ ™ s editors, in 1957 â $» but also
for the treatment of many other disorders.
Warren D. Shlomchik, M.D. Yale University Memory T
cells for improved immune reconstitution and GVL in allogeneic
hematopoietic stem cell transplantation
When undergoing treatment
for leukemia many patients require
hematopoietic stem cell (HSC)
transplantation to replace the blood
stem... Continue reading Mice pave the way to a cord blood transplant advance
Human placenta and chorion: potential additional sources of
hematopoietic stem cells for transplantation.
These allogeneic
cells have the potential to participate in immune surveillance
for breast or other cancers as observed in clinical
hematopoietic stem cell transplantation.
But until gene therapy is more commonplace, the only curative treatment
for sickle
cell is
hematopoietic stem cell transplantation.
Today, this study presents tangible progress
for patients with a devastating genetic brain disease and opens the door
for application to other neurological diseases that are treatable with
hematopoietic stem -
cell transplantation.
Duval M, Klein JP, He W, Cahn JY, Cairo M, Camitta BM, Kamble R, Copelan E, de Lima M, Gupta V, Keating A, Lazarus HM, Litzow MR, Marks DI, Maziarz RT, Rizzieri DA, Schiller G, Schultz KR, Tallman MS, Weisdorf D.
Hematopoietic stem -
cell transplantation for acute leukemia in relapse or primary induction failure.