Since MAOA is an X-linked gene [11],
hemizygous males from this family effectively represent functional gene knockouts.
Deletion of the gene was not lethal and there was no overt phenotype either in
hemizygous males -LRB-- / y) or in homozygous females -LRB-- / --RRB-.
(A) Genotype documentation of - / y
hemizygous males and - / - homozygous females; evidence of Slc6a14 deletion in colon and lung tissues from - / y
hemizygous males and - / - homozygous females; expression of Slc6a14 in colon (C) and lung (L) but not in mammary gland (M) in wild - type (WT) female mice.