Sentences with phrase «hemogenic endothelium»

Cell Metabolism: Activation of TRPV1 by Dietary Capsaicin Improves Endothelium - Dependent Vasorelaxation and Prevents Hypertension

Wine has been shown to be a promotor of nitric oxide (NO) release in the arterial endothelium under the influence of wine polyphenols and NO is associated with improved arterial wall elasticity, decrease arteriosclerosis, and blood pressure regulation.

The grand plan envisioned by Ohio State University investigator Nicanor Moldovan and his colleagues entails sowing cells harvested from vessel lining, or endothelium, in silicon molds shaped like capillaries.

With our human gut - on - a-chip, we can not only culture the normal gut microbiome for extended times, but we can also analyze contributions of pathogens, immune cells, and vascular and lymphatic endothelium, as well as model specific diseases to understand complex pathophysiological responses of the intestinal tract.»

The team used cells lining brain capillaries called endothelium, and cells from placenta, which represent Zika's route across the blood - brain barrier and the transmission path from mother to child, respectively.

In experiments conducted on human lung endothelial cells and in mice, the researchers showed that NS1 caused permeability of the endothelium, which lines the walls of blood and lymph vessels.

The TEER measurement is used to quantify the flow of ions between electrodes and across the tissue - tissue interface made of an organ - specific epithelium and endothelium that is a core component of many of the Institute's human Organ Chips.

Using the TEER - MEA chip, the researchers built a beating vascularized Heart Chip in which human cardiomyocytes are cultured in one microfluidic channel that is separated by a thin semi-permeable membrane from a second, parallel endothelium - lined vascular channel.

In the case of heart disease, Reaven says that high blood concentrations of insulin and glucose can damage the endothelium that lines coronary arteries and set the stage for the formation of plaques.

Red wine stimulates the formation of endothelium - dependent relaxation factors such as nitric oxide, which improve endothelial function in coronary arteries possibly because of the high phenol concentration in red wine.

For the subset of more recent patients, the researchers assessed tumor cell behavior — in particular, cancer cells» ability to cross the endothelium (inner layer) of blood vessels.

Based on studies of other tissues, the genes very well could play an essential role in the health of the corneal endothelium, according to the study authors.

The endothelium is the innermost lining of all blood vessels that interacts with circulating blood.

Corneal sections from a person with Fuchs dystrophy show the presence of ATP1B1 in the corneal endothelium.

Affecting both eyes, Fuchs occurs when cells die in the endothelium, the innermost layer of the cornea, and the body fails to replace them.

As the endothelium layer dies, fluid accumulates in the central or stromal layer of the cornea leading to edema or swelling.

In this case, disruption of stable vascular endothelium disrupts this dormant niche and encourages the formation of a microenvironment that sparks micrometastatic outgrowth.»

«Ours is the first study to define the dormant niche on a cellular and molecular basis, and it is interesting that the culprit is the tissue we so often assume is a passive bystander, the microvascular endothelium,» Ghajar says.

The inner cell layer that lines vessels, known as the endothelium, is present in all the blood vessels of the body.

As part of this effort, Dr. Weinstein and his colleagues inserted a gene for a protein that turns green the cells that line the endothelium of selected embryonic veins and in the lymphatic system — the network of vessels through which immune cells travel in the body.

The research indicates that early onset of menopausal symptoms is associated with dysfunction of the endothelium, which is the lining of blood vessels.

«Previously, we thought that all of the cells in the corneal endothelium were unable to divide, but we were surprised to find this small population of dormant stem cells capable of proliferating,» said principal investigator Ula Jurkunas, M.D., a corneal and refractive surgeon at Massachusetts Eye and Ear and Associate Professor of Ophthalmology at Harvard Medical School.

The dysfunction of endothelium is a common denominator of several cardiovascular diseases, particularly those associated with ischemic events.

The corneal endothelium is responsible for pumping water throughout the cornea to keep vision clear, and when cells of the corneal endothelium die, they do not regenerate.

These studies, performed at Ohio University, are the first to identify the molecular mechanism of vitamin D3 - triggered restoration of the function of damaged endothelium in the cardiovasculature.

Researchers from Massachusetts Eye and Ear have, for the first time, identified rapidly proliferating cells (known as «neural crest - derived progenitor cells») in the corneal endothelium of specimens from normal corneas and from corneas with Fuchs» Endothelial Corneal Dystrophy (FECD), a condition in which the cells responsible for keeping the cornea clear die prematurely — often leading to blindness.

Therefore, the authors suggest that vitamin D3 may be of clinical importance in the restoration of dysfunctional cardiac endothelium after heart attack, capillary endothelium after brain ischemia (stroke), hypovolemia, vasculopathy, diabetes and atherosclerosis.

While these studies were performed using a cellular model of hypertension, the implication of vitamin D3 on dysfunctional endothelium is much broader.

After six weeks, researchers assessed how well the lining of blood vessels, or the endothelium, functioned, by measuring how much subjects» arteries dilated with increased blood flow.

In the process they induce inflammation; the cells also secrete other inflammatory chemicals, like interleukin - 6 and tumor necrosis factor - alpha, which are known to adhere to the endothelium of the blood vessels, an early event in atherosclerosis.

«Our study provides the first evidence that endothelial CD146 plays a dual role on endothelium, facilitating leukocyte extravasations and angiogenesis, thus promoting inflammation,» says Dr. Yan.

The researchers believe that MitoQ affects the endothelium, a thin layer of cells that lines our blood vessels.

Cortisone helps to enhance the barrier function of the endothelium, preventing vascular leakage and further infiltration of the alveolar space by immune cells.

One of the many functions of the endothelium is to help arteries dilate when necessary.

In addition, when these transcription factors lose their function, terminal differentiation into the vascular endothelium (completion of differentiation) is completely suppressed, and genes that are key to differentiation into vascular endothelial cells as well as transcription factors that maintain the undifferentiated state are adversely induced.

Endothelial cells form the innermost layer of the blood vessels - the endothelium - and have the function of containing blood inside the vessels while allowing the passage of nutrients to tissues.

Furthermore, an examination of the histone code revealed that the regulatory genomic region of the transcription factors (ETS / GATA / SOX) was found to have gradually switched from a «brake histone mark,» which suppresses transcription, to an «accelerator histone mark,» which activates transcription, while in the process of differentiating into the vascular endothelium.

Until now, no dengue viral proteins have been linked to vascular endothelium permeability (that is, vascular leakage).

In drug development, particular attention is paid to the expression and function of membrane transporters expressed in epithelia of the intestine, liver and kidney, and in the endothelium of the blood - brain and blood - testis barriers.

Other data obtained in this report (BrdU nitroblue tetrazolium staining by alkaline phosphatase and fluorescence due to fluorescein) would further suggest that putative stem cells are located in the posterior limbus between the peripheral endothelium and the trabecular meshwork.

Endothelia were stained with alizarin red, examined under the microscope, and photographed at 5 different sites (microscope, × 100; digital magnification, × 2.83).

It may be useful for corneal endothelium transplantation.

The BrdU staining (AP - BrdU assay) procedure was carried out to demonstrate cellular division at the periphery of the corneal endothelium.

Paull and Whikehart [7] have also shown that p53 and TAp63 (a p53 family member) are relatively elevated in the normal central human corneal endothelium suggesting that these proteins inhibit cell - cycle promotion from the G1 to S phase.

The findings suggest an alternate indirect effector pathway that requires processing and presentation of the donor H - Y antigen by recipient endothelium and have implications for both transplantation and autoimmune disease.

After wounding, BrdU fluorescence extended into the corneal endothelium.

Therapeutic potential of AAV - mediated MMP - 3 secretion from corneal endothelium in treating glaucoma.

Multiple hematoxylin - eosin - stained sections showed the presence of endothelium with intact Descemet membrane and no stromal tissue.

The fluorescence extended, without interruption, from the limbus to the corneal endothelium (Figure 7B).

In this study, the reaction for telomerase in the peripheral corneal endothelium was manifest (Figure 2).