Sentences with word «heparin»

Use of heparins in patients with cancer: individual participant data meta - analysis of randomised trials study protocol

Pierre Sinay, an organic chemist from the Ecole Normale Supérieure in Paris, points out that a synthetic drug will remove the theoretical risk of pathogens stowing away in heparin preparations from pigs and causing human disease.

In the first stage, the resident gave the project's six dogs a single dose of oral heparin then collected samples of blood, urine and feces at intervals over 72 hours.

But to be fair, much of the concern is rooted in some scary generic drug scandals, in which toxic substances made it into a medication that was produced overseas, such as occurred with heparin in 2008.

To prevent these potentially deadly infections, hospitals traditionally use the blood - thinning drug heparin to block germ - attracting blood clots from forming inside catheters.

Philippe Gabriel Steg, M.D., of the Université Paris - Diderot, Sorbonne - Paris Cité, Paris, and investigators with the TAO trial compared the clinical efficacy and safety of otamixaban with that of unfractionated heparin plus eptifibatide in 13,229 patients with NSTE - ACS and a planned early invasive strategy.

He has published an article outlining a unique case of high potassium induced by heparin therapy in a dog.

However, the doctors wouldn't risk putting another needle in my back now that the original had already been removed and I was back on heparin injections.

Previously, the researchers found that negatively charged polymers, such as heparin sulfate, interfere with the binding of SEVI to target cells.

Further analysis of each individual condition could reveal that heparin alone or in combination with other drugs, such as aspirin, may help to prevent one or more of those conditions in women who had, say, prior severe preeclampsia or who gave birth to a child with severe low birth weight.

TCT can also be prolonged if pets receive heparin anticoagulant.

A comparable reduction in plasma TG levels occurred after heparin injection of mice treated with ApoC - III ASO (Figure 7A).

The most alarming report involved contaminated batches of the blood thinner heparin, which caused at least three deaths and is under suspicion in dozens of others.

«We had systems that bound DNA, and they can all, in principle, be used to bind heparin as well..., so we could start pretty much instantly,» he says.

He was involved, you may remember from last year, there was the unfortunate scandal involving tainted heparin.

Anon — Hmmm, maybe it wasn't heparin, but something else?

An oral formulation would simplify the dosing process and allow heparin therapy to continue without frequent injections.

Developing a three dimensional in vitro cell culture model for studying breast and prostate cancer using starPEG - heparin hydrogels.

This led them to hypothesize that the SEVI fibrils bind target cells by interacting with cell - surface HSPG, naturally occurring anionic carbohydrate polymers with a structure that is closely related to heparin sulfate.

The tumors release excess amounts of the biological chemicals heparin and histamine, which are normally produced by mast cells.

Serena was started on an IV of heparin right away.

Maurice Petitou started with a sugar chain and tacked on the exact five sugars that heparin uses to grapple onto antithrombin.

He leads the NIH - NCI - funded Cancer Genomics Laboratory at the Kimmel Cancer Center where he works on mRNA expression profiling for the retinoblastoma pathway, X-linked mental retardation, and transcriptome analysis of platelets in patients with heparin induced - thrombocytopenia.

Administration of tamoxifen to LPL - deficient mice resulted in a significant reduction in Lpl mRNA expression in liver, muscle, heart, and adipose tissue (Supplemental Figure 5A) and in LPL activity in plasma (after i.v. heparin administration), muscle, heart, and adipose tissue (Supplemental Figure 5B).

With an allergic reaction, there is a release of mast cells, which contain heparin and histamine and then follows by an increase in IgE.

With more recent horrifying headlines about heparin drug errors harming children — and even, tragically taking the lives of two babies at a Texas hospital — WebMD recently sat down with Dennis and Kimberly Quaid.

But it was also great [is] that Linhardt has actually been involved in trying to develop a completely synthetic source of heparin so that, potentially in the future, you could avoid all of these kinds of contamination problems.

In patients undergoing transradial primary percutaneous coronary intervention (PCI) for ST elevation myocardial infarction (STEMI), there was no significant difference in the rate of a composite of death, myocardial infarction and stroke whether they were anticoagulated with bivalirudin or unfractioned heparin, according to a study in JACC: Cardiovascular Interventions.

«Our sensitivity analysis provides some insights into direct comparisons of bivalirudin and heparin when GPIIb / IIIa inhibitors are forced out of the equation and suggests that in the direct comparison bivalirudin may have superior outcomes,» Jovin said.

«We started with the sugar heparin, which is highly negatively charged, and saw very tight binding with the Zika envelope protein.

But some patients are allergic to protamine sulfate, the compound now used to remove heparin from the bloodstream.

Smith realized he could create self - assembled nanoscale systems that, when injected, would hunt down and bind circulating heparin and then be excreted.

In February FDA officials admitted that they had never inspected Changzhou SPL, the manufacturing plant in Changzhou, China, to which they traced the contaminated heparin.

Other heparin experts are elated.

But heparin also attaches to a substance called PF4, which in certain patients can trigger new clots.

The new drug turned out to be up to 10 times more powerful than heparin at preventing new clots.

After a heart attack or stroke, patients are often given a drug called heparin to prevent blood clots.

Petitou treated lab rats with either compound 12 or standard heparin, then tried to induce blood clots.

Defined Polymer - Peptide Conjugates to Form Cell - Instructive starPEG - Heparin Matrices In Situ.

Andrea Zieris (Werner, LG)-- «Modulation of growth factor functionality through immobilization in starPEG - heparin networks» (2012)

Hyaluronan - based heparin - incorporated hydrogels for generation of axially vascularized bioartificial bone tissues: In vitro and in vivo evaluation in a PLDLLA - TCP - PCL - composite system.

These findings show that suppression of ApoC - III did not alter heparin - induced lipolysis, suggesting that the reduction of ApoC - III did not affect LPL hydrolysis of TRL substrates.

Administration of heparin resulted in a rapid reduction of plasma TGs in WT, Ldlr — / — Ndst1fl / fl Alb - Cre +, and Ldlr — / — Lrp1fl / fl Alb - Cre + mice under fasting conditions (Figure 7A).