Sentences with word «hepatocellular»

CD90 promotes cell migration, viability and sphere - forming ability of hepatocellular carcinoma cells.

The rates of nonalcoholic fatty liver disease are increasing with the rising prevalence of obesity and are associated with an increase in the incidence of hepatocellular carcinoma.

Niclosamide induced cell apoptosis via upregulation of ATF3 and activation of PERK in hepatocellular carcinoma cells.

Studies from patients with hepatocellular carcinoma showed that neoplasia induced a defect of DC maturation 189.

This discovery may lead to a therapy for hepatocellular carcinoma (HCC), the most common type of liver cancer and the third most common cause of cancer deaths.

It wasn't long before stunning news was received: Taylor had been diagnosed with a rare form of liver cancer called fibrolamellar hepatocellular carcinoma.

In a follow - up study, Pickens et al. showed that despite inducing the same overall level of hepatic fat accumulation, fructose was more effective than glucose at inducing hepatocellular injury in mice fed MCD diets for 21 days (16).

Summary RRs of hepatocellular cancer for high coffee drinkers versus non / lowest drinkers from included studies.

Coffee contains large amounts of antioxidants, such as chlorogenic acids, and experimental studies in animals have demonstrated an inhibitory effect of coffee and chlorogenic acids on hepatocellular carcinogenesis [84].

Biochemical findings are suggestive of hepatocellular dysfunction.

I need to find grants to fund projects at the graduate and postdoctoral level in the area of molecular biology and immunology of diseases such as hepatocellular carcinoma / hepatitis B or colorectal cancer.

Shares of Exelixis, Inc. (NASDAQ: EXEL) were trading higher by 20 percent early Monday morning after the company announced an encouraging update for its CABOMETYX (cabozantinib) therapy for the treatment of patients with advanced hepatocellular carcinoma.

Cancers of the liver cells are called hepatocellular adenomas and carcinomas.

In the US, despite the availability of a vaccine, an estimated 3,000 die annually from hepatocellular cancer or chronic liver disease caused by hepatitis B.

Tumors of liver cells (hepatocellular tumors) are rare (less than 1 % of all tumors).

Large scale genomic and transcriptomic interrogation of cancer has confirmed the incredible variability of the genomic landscape of many tumors including hepatocellular carcinoma (HCC), in which more than 28,000 different somatic mutations have been identified.

Hepatic and biliary diseases including lipidosis, acute hepatitis / hepatocellular necrosis, cholangiohepatitis, biliary obstruction, hepatic encephalopathy, chronic active hepatitis.

Hepatocellular adenoma and hepatoblastoma are extremely rare and they hardly show any clinical signs.

INTERPRETATION: Hepatic lipidosis with neutrophilic / lymphocytic inflammation and mild hepatocellular atypia.

Nonalcoholic fatty liver disease (NAFLD)-- induced hepatocellular carcinoma (HCC) is an emerging malignancy in the developed world; however, mechanisms that contribute to its formation are largely unknown, and targeted therapy is currently not available.

Support for this notion comes from several studies that have indicated the involvement of the p21waf1 / cip1 inactivation in hepatocellular carcinogenesis (46, 47).

Dogs with nodular hepatocellular carcinoma usually show metastasis to the lymph nodes, adrenal glands, lungs, peritoneum, pancreas, kidneys, intestines, urinary tract, bladder and spleen.

Researchers enrolled 573 patients with intermediate or advanced stage hepatocellular carcinoma, who had all been previously treated with sorafenib, and randomized them 2:1 to 160 mg oral regorafenib or placebo once daily for 1 - 3 of each four week cycle, in addition to best supportive care.

Polyunsaturated fat in the methionine - choline - deficient diet influences hepatic inflammation but not hepatocellular injury.

The researchers looked at hepatocellular carcinoma, or HCC, the most common type of liver cancer.

«It's still early,» he said, «but perhaps one day this approach will provide a novel strategy to prolong lifespans, prevent or reverse liver fibrosis and prevent, delay or cure hepatocellular carcinoma in humans.»

Hepatocellular autophagy modulates the unfolded protein response and fasting - induced steatosis in mice.

Dietary fructose exacerbates hepatocellular injury when incorporated into a methionine - choline - deficient diet.

Estrogen suppresses hepatocellular carcinoma cells through ERß - mediated upregulation of the NLRP3 inflammasome.

HuH - 7 (human HCC), HepG2 (human hepatocellular blastoma), 293T (human embryonic kidney fibroblast), HeLa (human cervical cancer cells), NIH 3T3 (murine fibroblast), and HCT116 (human colon cancer) and its derived cell line HCT116 p21 − / − (kindly provided by Dr. B. Vogelstein, Howard Hughes Medical Institute, Chevy Chase and the Sydney Kimmel Comprehensive Cancer Center of the Johns Hopkins University School of Medicine, Baltimore, MD; ref.

Impaired lipid metabolism with excess release of FA from adipose tissue leads to overspill of circulating lipids and thus to ectopic nonadipose lipid accumulation in the liver hepatocellular lipids (HCL), muscle intramyocellular lipids (IMCL), and myocard myocardial lipids (MYCL) with detrimental consequences of lipotoxicity.

HepG2 hepatocellular carcinoma cells were purchased from ATCC and maintained in DMEM media containing 10 % FCS and antibiotics.

Approximately 3 % — 4 % of patients with cirrhosis will develop hepatocellular carcinoma (HCC) per year

As our aim was to indicate general tissue specific carcinogenic properties, we used all the known subtypes of these cancers, including (1) hyper mutated and non-hypermutated colon cancers; (2) lung adenocarcinomas, large cell carcinomas, and squamous cell carcinomas (3) HER2 positive, basal, luminal A and luminal B breast cancers; and (4) hepatitis B or hepatitis C, cirrhosis or other agent causing hepatocellular carcinoma data.

Ellagic acid reduced the number of altered foci and the incidence of hepatocellular neoplasms in rats with liver cancer induced by N -2-fluorenylacetamide (Tanaka).

In addition, some studies have reported an inverse association between coffee consumption and risk of hepatocellular cirrhosis, which is strongly related to HCC [87].

More recently, coffee consumption has been associated with reductions in the risk of several chronic diseases, including type 2 diabetes mellitus, Parkinson's disease and hepatocellular disease [2 — 4].

The serum liver enzyme activity (ALP, ALT, and AST) is normal to mildly (two or three times) increased consistent with a lesion of hepatic atrophy and minimal hepatocellular injury or intrahepatic cholestasis.

There is an increase in nondegenerate neutrophilsm, small to intermediate mature lymphocytes, rare macrophages, rare plasma cells, and rare lymphoblasts seen intimately associated with hepatocellular clusters.

Comment: Lipid accumulation can be seen with pancreatitis, endocrinopathy, hepatocellular insult, neoplasia, idiopathic, and other rare conditions.

Hepatic hypoplasia is recognized histologically as atrophy of hepatic lobules, compressed hepatic cords with dilated sinusoids, close proximity of portal triads, portal vein hypovascularity, hepatocellular degeneration (vacuolization, lipidosis) and proliferation of the small vessels, arterioles, and lymphatics.

Ultrastructural hepatocellular features associated with spontaneous severe hepatic lipidosis in cats

With the approval of the local ethics committee, a 16 - year - old boy with a rare type of liver cancer called fibrolamellar hepatocellular carcinoma was given infusions of 3BP into the blood vessels supplying the tumor, formulated in a proprietary and patented fashion.

While the last decade has seen many potential new agents for hepatocellular carcinoma fail in clinical trials, phase I and II data from early regorafenib trials were promising, and led to the initiation of this international, multi-center phase III trial.

«Cellular senescence refers to a state of irreversible cell - cycle arrest combined with the secretion of proinflammatory cytokines and hepatocellular dysfunction.