Sentences with phrase «hepatocyte models»

Another characteristic used to evaluate hepatocyte models is the presence of functional alpha -1-antitrypsin (α1AT), a protease inhibitor produced in the liver.

Not exact matches

Gandhi's research team is the first to develop a mouse model with depleted levels of a protein called augmenter of liver regeneration (ALR), which is essential for the survival of liver cells called hepatocytes.

To validate their computer modeling predictions, researchers performed experiments in human cancer cell lines, mouse liver samples and primary human hepatocytes.

«Investigators have been developing in - vitro liver models for 40 years, but all of those systems ignore the distinct patterns of metabolically active hepatocytes that exist within the liver sinusoid» says Martin Yarmush, MD, PhD, director of the MGH - CEM and the paper's senior author.

«Liver tissue model accurately replicates hepatocyte metabolism, response to toxins: Microfluidic device may help predict toxic effects of new drugs, study liver disease.»

However, Takebe's liver bud has the advantage of being grown from iPS cells, rather than, for example, the primary human hepatocytes used in Bhatia's graft, which could make it useful in modelling rare diseases or examining the specific genetic backgrounds of the iPS cell donors.

Human primary hepatocytes and immortalized cell lines (e.g., HepaRG) are used to study these disorders, but due to these cells» high variability, low availability, short assay window, or lack of physiological relevance, researchers studying metabolic diseases are searching for more robust and reliable models.

Rat Hepatocyte Culture Model of Macrosteatosis: Effect of Macrosteatosis Induction and Reversal on Viability and Liver - specific Function.

Currently, primary hepatocytes are the most common cell model, but their utility is fundamentally constrained by the substantial variation between donors and the finite number of cells that are harvestable from each donor.

However, hiPS cell - derived hepatocytes are only useful as an in vitro model system and for gene editing applications if they recapitulate critical hepatocyte functions.

Currently, primary hepatocytes are the most common cell model, but their utility is constrained by large variation between donors and a finite number of cells harvestable from each donor.

Here, we present data demonstrating the suitability of these hiPS cell - derived hepatocytes for modeling the role of hepatocytes in metabolic disorders.

Explains Verma, «This robust model system opens the door to utilize human hepatocytes for purposes that were previously impossible.

Taken together, these results demonstrated that disease - specific human iPS cell — derived hepatocytes are capable of modeling key pathological feature of A1ATD in vitro and may also prove useful for future drug screening assays.