The researchers found that patients from MODY3 families had one of several different mutations in the gene for
hepatocyte nuclear factor 1 alpha (HNF -1-alpha) but healthy subjects had normal copies of the gene.
Hepatocyte nuclear factor 4α (HNF4α) is a transcription factor required for liver development and the control of expression of liver - specific genes, and it is associated with several critical metabolic pathways [3].
Gonzalez, F. J. Regulation of
hepatocyte nuclear factor 4 alpha - mediated transcription.